HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 27684187, 8307946, 30194290, 28205554, 10783161, 34079125, 32591521, 16041367, 16093354, 25852190, 26721396, 15192046, 9564038, 31980649, 10882715, 34526658, 19029954, 23153539, 10958680, 20080631 and 2 others

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Identification Methods affinity chromatography technology, proximity labelling technology, fluorescent resonance energy transfer, two hybrid, protein complementation assay, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~Ras, Pkinase~Ras, RBD~Ras
Common GO terms GO:0000165 - MAPK cascade
GO:0005737 - cytoplasm
GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 189
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024