Protein: PTPRK
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)

Gene: PTPRK
Organism: Homo sapiens
Interactions: 203
UniProt ID: Q15262

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363315

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.895

High

439741

INSR
Insulin receptor

4

20

High-throughput

0.892

High

183253

LAMA5
Laminin subunit alpha-5

3

14

High-throughput

0.861

High

296354

ATRN
Attractin

3

8

High-throughput

0.861

High

441428

CHLE
Cholinesterase

3

4

High-throughput

0.861

High

462878

LAMB1
Laminin subunit beta-1

3

9

High-throughput

0.861

High

1144599

LAMA3
Laminin subunit alpha-3

3

13

High-throughput

0.861

High

1144601

MICA
MHC class I polypeptide-related sequence A

3

7

High-throughput

0.861

High

1144613

SUSD1
Sushi domain-containing protein 1

3

18

High-throughput

0.861

High

1144627

AMGO3
Amphoterin-induced protein 3

3

11

High-throughput

0.861

High

1144644

PXDN
Peroxidasin homolog

3

4

High-throughput

0.861

High

1144655

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

3

6

High-throughput

0.861

High

1144657

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

3

2

High-throughput

0.861

High

1144678

LRP1B
Low-density lipoprotein receptor-related protein 1B

3

4

High-throughput

0.861

High

1144645

PTPRU
Receptor-type tyrosine-protein phosphatase U

3

18

High-throughput

0.855

High

1144625

ANR46
Ankyrin repeat domain-containing protein 46

3

5

High-throughput

0.839

High

937398

LAMB2
Laminin subunit beta-2

2

9

High-throughput

0.789

High

1144626

AMGO1
Amphoterin-induced protein 1

2

8

High-throughput

0.789

High

654500

FBLN1
Fibulin-1

3

2

High-throughput

0.770

High

1144614

EST3
Carboxylesterase 3

3

4

High-throughput

0.770

High

1144647

PCSK5
Proprotein convertase subtilisin/kexin type 5

3

8

High-throughput

0.770

High

410858

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.737

High

480444

CD48
CD48 antigen

1

10

High-throughput

0.691

High

731849

CEAM8
Cell adhesion molecule CEACAM8

1

12

High-throughput

0.691

High

761227

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.691

High

1120526

NID2
Nidogen-2

1

3

High-throughput

0.691

High

1144602

HFE
Hereditary hemochromatosis protein

1

6

High-throughput

0.691

High

1144624

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.691

High

1144659

TMPSD
Transmembrane protease serine 13

1

8

High-throughput

0.691

High

1144682

BTNL2
Butyrophilin-like protein 2

1

11

High-throughput

0.691

High

1144686

CLC4A
C-type lectin domain family 4 member A

1

7

High-throughput

0.691

High

609682

LEG3
Galectin-3

4

20

High-throughput

0.691

High

127335

LEG8
Galectin-8

3

20

High-throughput

0.667

High

178272

NPC1
NPC intracellular cholesterol transporter 1

3

1

High-throughput

0.667

High

219810

CHSTA
Carbohydrate sulfotransferase 10

3

1

High-throughput

0.667

High

269668

PLXA2
Plexin-A2

3

16

High-throughput

0.667

High

551786

CO6A1

3

2

High-throughput

0.667

High

551858

CO6A2

3

2

High-throughput

0.667

High

586377

ARSB
Arylsulfatase B

3

4

High-throughput

0.667

High

833464

WNT5A
Protein Wnt-5a

3

1

High-throughput

0.667

High

922815

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

3

6

High-throughput

0.667

High

928774

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

3

1

High-throughput

0.667

High

1105729

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

3

4

High-throughput

0.667

High

1120442

SCRB2
Lysosome membrane protein 2

3

1

High-throughput

0.667

High

1144607

GT253
Inactive glycosyltransferase 25 family member 3

3

3

High-throughput

0.667

High

1144620

CD109
CD109 antigen

3

1

High-throughput

0.667

High

1144621

UBR3
E3 ubiquitin-protein ligase UBR3

3

1

High-throughput

0.667

High

1144641

SCRB1
Scavenger receptor class B member 1

3

1

High-throughput

0.667

High

1144660

CNTP3
Contactin-associated protein-like 3

3

6

High-throughput

0.667

High

1144676

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

3

1

High-throughput

0.667

High

859838

RL28
Large ribosomal subunit protein eL28

3

2

High-throughput

0.662

High

611732

BMP7
Bone morphogenetic protein 7

1

0

High-throughput

0.656

High

136607

MANBA
Beta-mannosidase

3

0

High-throughput

0.638

High

844197

ECE1
Endothelin-converting enzyme 1

3

0

High-throughput

0.638

High

1089095

HYAL2
Hyaluronidase-2

3

0

High-throughput

0.638

High

1144631

P3H3
Prolyl 3-hydroxylase 3

3

0

High-throughput

0.638

High

1144680

CATF
Cathepsin F

3

0

High-throughput

0.638

High

882684

EFTU
Elongation factor Tu, mitochondrial

2

1

High-throughput

0.628

High

1144687

PCDGG
Protocadherin gamma-B4

2

18

High-throughput

0.628

High

1144690

PCDGD
Protocadherin gamma-B1

2

18

High-throughput

0.628

High

663547

CMA1
Chymase

1

6

High-throughput

0.618

High

1144688

KLK5
Kallikrein-5

1

8

High-throughput

0.618

High

366544

TPA
Tissue-type plasminogen activator

1

8

High-throughput

0.618

High

466265

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

601299

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

699756

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

High-throughput

0.618

High

705702

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

17

High-throughput

0.618

High

774369

BASI
Basigin

1

8

High-throughput

0.618

High

845645

MUC18
Cell surface glycoprotein MUC18

1

15

High-throughput

0.618

High

953461

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

962070

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

978020

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1022389

IDD
Integral membrane protein DGCR2/IDD

1

3

High-throughput

0.618

High

1144617

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

6

High-throughput

0.618

High

1144623

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

10

High-throughput

0.618

High

1144646

ESR2
Estrogen receptor beta

1

1

High-throughput

0.618

High

1144665

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1144668

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

3

High-throughput

0.618

High

1144689

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

2

High-throughput

0.618

High

565392

ITA4
Integrin alpha-4

2

6

High-throughput

0.611

High

125471

LEG9
Galectin-9

3

20

High-throughput

0.609

High

582334

ARSA
Arylsulfatase A

3

4

High-throughput

0.609

High

756549

GALNS
N-acetylgalactosamine-6-sulfatase

3

4

High-throughput

0.609

High

885471

MA2A2
Alpha-mannosidase 2x

3

1

High-throughput

0.609

High

1144610

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

3

1

High-throughput

0.609

High

1144615

ARSK
Arylsulfatase K

3

4

High-throughput

0.609

High

1144652

ARSG
Arylsulfatase G

3

4

High-throughput

0.609

High

1144679

DNJB9
DnaJ homolog subfamily B member 9

3

6

High-throughput

0.609

High

1030782

DEF5
Defensin alpha 5

2

0

High-throughput

0.602

High

1144634

LYPD1
Ly6/PLAUR domain-containing protein 1

2

0

High-throughput

0.602

High

480797

LEG1
Galectin-1

2

20

High-throughput

0.601

High

1144675

EVA1B
Protein eva-1 homolog B

2

1

High-throughput

0.601

High

1144685

FBX2
F-box only protein 2

2

9

High-throughput

0.601

High

943945

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.590

High

244576

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

0

High-throughput

0.586

High

244463

MGRN1
E3 ubiquitin-protein ligase MGRN1

2

0

High-throughput

0.585

High

193577

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

5

High-throughput

0.575

High

440082

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.575

High

472064

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.575

High

484144

PGFRB
Platelet-derived growth factor receptor beta

1

19

High-throughput

0.575

High

533850

GHR
Growth hormone receptor

1

17

High-throughput

0.575

High

651334

CBL
E3 ubiquitin-protein ligase CBL

1

8

High-throughput

0.575

High

691748

MK03
Mitogen-activated protein kinase 3

1

11

High-throughput

0.575

High

834191

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.575

High

840882

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.575

High

1038437

TIE2
Angiopoietin-1 receptor

1

17

High-throughput

0.575

High

1144639

MOT10
Monocarboxylate transporter 10

1

3

High-throughput

0.575

High

1144656

MF14A
Hippocampus abundant transcript 1 protein

1

6

High-throughput

0.575

High

1144672

MMP26
Matrix metalloproteinase-26

2

2

High-throughput

0.574

High

577764

PLAK
Junction plakoglobin

1

20

Small-scale

0.561

High

764768

CTNB1
Catenin beta-1

1

20

Small-scale

0.561

High

1144629

ERO1B
ERO1-like protein beta

2

1

High-throughput

0.558

High

1144664

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.555

High

323382

TRI37
E3 ubiquitin-protein ligase TRIM37

1

8

High-throughput

0.553

High

1144622

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.553

High

1144635

MINK1
Misshapen-like kinase 1

1

5

High-throughput

0.553

High

1144661

TANC1
Protein TANC1

1

2

High-throughput

0.553

High

279573

LAT3
Large neutral amino acids transporter small subunit 3

1

0

High-throughput

0.546

High

1144596

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

18

Small-scale

0.545

High

127969

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

5

High-throughput

0.541

High

64358

CDHR4
Cadherin-related family member 4

1

20

High-throughput

0.536

High

941784

ARL4C
ADP-ribosylation factor-like protein 4C

1

5

High-throughput

0.536

High

1051665

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

9

High-throughput

0.536

High

1133863

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

10

High-throughput

0.536

High

1144630

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.536

High

1144642

OIT3
Oncoprotein-induced transcript 3 protein

1

3

High-throughput

0.536

High

1144649

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

3

High-throughput

0.536

High

1144674

S39A9
Zinc transporter ZIP9

1

2

High-throughput

0.536

High

598094

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

High-throughput

0.515

High

1144611

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

4

High-throughput

0.514

High

351827

BY55
CD160 antigen

1

0

High-throughput

0.513

High

851121

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.513

High

342566

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.489

High

946307

NXPH1
Neurexophilin-1

1

1

High-throughput

0.489

High

1144643

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

1

High-throughput

0.489

High

1144651

LEG12
Galectin-12

1

20

High-throughput

0.489

High

1144663

CSTL1
Cystatin-like 1

1

2

High-throughput

0.489

High

1144666

CST9L
Cystatin-9-like

1

2

High-throughput

0.489

High

1144673

CBLN4
Cerebellin-4

1

3

High-throughput

0.489

High

995046

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

130108

PGRC1
Membrane-associated progesterone receptor component 1

1

3

Small-scale

0.479

High

175368

PLXB2
Plexin-B2

1

17

High-throughput

0.479

High

218206

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

907907

PLXA3
Plexin-A3

1

17

High-throughput

0.479

High

951164

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

1036881

SP3
Transcription factor Sp3

1

2

High-throughput

0.479

High

1144598

MA2A1
Alpha-mannosidase 2

1

1

High-throughput

0.479

High

1144600

T132A
Transmembrane protein 132A

1

1

High-throughput

0.479

High

1144616

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1144628

FRAS1
Extracellular matrix organizing protein FRAS1

1

6

High-throughput

0.479

High

1144658

PKP4
Plakophilin-4

1

20

High-throughput

0.479

High

1144671

CHSTC
Carbohydrate sulfotransferase 12

1

1

High-throughput

0.479

High

1144681

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1144683

PLXA1
Plexin-A1

1

16

High-throughput

0.479

High

332152

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.464

High

284398

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

High-throughput

0.458

High

1125444

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

Small-scale

0.458

High

1144648

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.458

High

618254

CADH2
Cadherin-2

1

20

High-throughput

0.445

High

857110

NSF
Vesicle-fusing ATPase

1

9

High-throughput

0.445

High

878464

PAXI
Paxillin

1

10

High-throughput

0.445

High

1133773

SL9A5
Sodium/hydrogen exchanger 5

1

1

High-throughput

0.445

High

1144606

NTCP5
Sodium/bile acid cotransporter 5

1

4

High-throughput

0.445

High

1144609

NPAL3
NIPA-like protein 3

1

4

High-throughput

0.445

High

1144618

ZNT10
Calcium/manganese antiporter SLC30A10

1

4

High-throughput

0.445

High

1144632

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

4

High-throughput

0.445

High

1144633

S39AB
Zinc transporter ZIP11

1

3

High-throughput

0.445

High

1144638

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

4

High-throughput

0.445

High

1144677

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.445

High

1144691

5MP1
eIF5-mimic protein 1

1

1

High-throughput

0.445

High

665259

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.439

High

67670

RHG32
Rho GTPase-activating protein 32

1

1

High-throughput

0.437

High

338474

SC24B
Protein transport protein Sec24B

1

1

High-throughput

0.437

High

868696

LEG7
Galectin-7

1

20

High-throughput

0.437

High

1004595

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

1144684

GNPTG
N-acetylglucosamine-1-phosphotransferase subunit gamma

1

5

High-throughput

0.437

High

722458

CTR1
High affinity cationic amino acid transporter 1

1

0

High-throughput

0.426

High

1144637

CCNY
Cyclin-Y

1

0

High-throughput

0.426

High

1144640

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.426

High

69779

ZN785
Zinc finger protein 785

1

1

High-throughput

0.407

High

1144653

SAAL1
Protein SAAL1

1

4

High-throughput

0.407

High

1144603

OFUT4
GDP-fucose protein O-fucosyltransferase 4

3

0

High-throughput

0.347

High

1144604

MKS3
Meckelin

3

0

High-throughput

0.347

High

1144605

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

3

0

High-throughput

0.347

High

1144636

PGLT1
Protein O-glucosyltransferase 1

3

0

High-throughput

0.347

High

1144650

C102A
Coiled-coil domain-containing protein 102A

3

0

High-throughput

0.347

High

1144654

TECT2
Tectonic-2

3

0

High-throughput

0.347

High

600497

ZNF3
Zinc finger protein 3

2

0

High-throughput

0.328

High

405465

KITH
Thymidine kinase, cytosolic

2

0

High-throughput

0.323

High

846816

BTD
Biotinidase

2

0

High-throughput

0.318

High

702188

LYOX
Protein-lysine 6-oxidase

1

0

Small-scale

0.305

High

280918

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

880012

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.279

Low

1144597

ZNF74
Zinc finger protein 74

1

0

High-throughput

0.279

Low

471591

CO4A2

1

0

High-throughput

0.249

Low

1144612

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.249

Low

1144619

B3GLT
Beta-1,3-glucosyltransferase

1

0

High-throughput

0.249

Low

1144662

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1144667

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1144669

SIAE
Sialate O-acetylesterase

1

0

High-throughput

0.249

Low

1144670

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

1144608

Q6FII1
Glutathione S-transferase kappa

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025