HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30639242, 30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 976
+	Hs
		349144 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		348527 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		665242 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		348673 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		EPHA7_HUMAN (4-974): 0: 1128: 50.30
+	Hs
		349222 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		1070202 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHA7_HUMAN (4-974): 0: 1128: 50.30
+	Hs
		348528 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		EPHA3_HUMAN (24-976): 0: 1111: 51.19
+	Hs
		665398 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHA3_HUMAN (24-976): 0: 1111: 51.19
+	Hs
		665604 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHB2_HUMAN (28-973): 0: 1089: 48.29
+	Hs
		872534 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHB4_HUMAN (14-970): 0: 986: 44.99
+	Hs
		349123 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		EPHA1_HUMAN (17-967): 0: 959: 49.38
+	Hs
		349876 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		EPHA1_HUMAN (17-967): 0: 959: 49.38
+	Hs
		349065 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		INSR_HUMAN (281-933): 1.71e-136: 445: 24.85
+	Hs
		348472 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		INSR_HUMAN (281-933): 1.71e-136: 445: 24.85
+	Hs
		349800 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		INSR_HUMAN (281-933): 1.71e-136: 445: 24.85
+	Hs
		349808 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		349070 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		348474 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433769 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		349807 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91