HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: PK3CG (P48736)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
Gene: PIK3CG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	10542052
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras, PI3K_rbd~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0035022 - positive regulation of Rac protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1102
+	Hs
		349183 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PK3CG_HUMAN (1-1102): 0: 1393: 100.00
+	Mm
		1142568 RASH_MOUSE (1-188): 6.53e-87: 255: 86.77		PK3CG_MOUSE (1-1102): 0: 1392: 94.10
+	Mm
		440303 RASN_MOUSE (1-189): 3.34e-86: 253: 85.71		PK3CG_MOUSE (1-1102): 0: 1392: 94.10
+	Hs
		348567 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PK3CG_HUMAN (1-1102): 0: 1393: 100.00
+	Mm
		699626 RASK_MOUSE (1-189): 4.5e-77: 230: 98.94		PK3CG_MOUSE (1-1102): 0: 1392: 94.10
+	Hs
		349170 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PK3CA_HUMAN (23-1093): 0: 1030: 32.92
+	Mm
		787349 RASH_MOUSE (1-188): 6.53e-87: 255: 86.77		PK3CA_MOUSE (23-1093): 0: 1029: 32.74
+	Mm
		440301 RASN_MOUSE (1-189): 3.34e-86: 253: 85.71		PK3CA_MOUSE (23-1093): 0: 1029: 32.74
+	Hs
		348554 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PK3CA_HUMAN (23-1093): 0: 1030: 32.92
+	Hs
		126186 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PK3CD_HUMAN (38-1091): 0: 1018: 31.31
+	Mm
		193571 RASH_MOUSE (1-188): 6.53e-87: 255: 86.77		PK3CD_MOUSE (38-1091): 0: 1016: 30.94
+	Mm
		193564 RASN_MOUSE (1-189): 3.34e-86: 253: 85.71		PK3CD_MOUSE (38-1091): 0: 1016: 30.94
+	Hs
		349946 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PK3CA_HUMAN (23-1093): 0: 1030: 32.92
+	Mm
		699616 RASK_MOUSE (1-189): 4.5e-77: 230: 98.94		PK3CA_MOUSE (23-1093): 0: 1029: 32.74
+	Mm
		193569 RASK_MOUSE (1-189): 4.5e-77: 230: 98.94		PK3CD_MOUSE (38-1091): 0: 1016: 30.94
+	Mm
		1142560 RASH_MOUSE (1-188): 6.53e-87: 255: 86.77		PK3CB_MOUSE (38-1091): 0: 949: 31.33
+	Dm
		442990 RAS1_DROME (1-165): 9.63e-88: 257: 85.46		P91634_DROME (29-1090): 0: 833: 29.19
+	Hs
		349368 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		Q4LE69_HUMAN (509-1094): 1.18e-132: 447: 20.00
+	Hs
		348701 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		Q4LE69_HUMAN (509-1094): 1.18e-132: 447: 20.00
+	Hs
		1070222 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		Q4LE69_HUMAN (509-1094): 1.18e-132: 447: 20.00