HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	30442766, 30639242, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 651
+	Hs
		349190 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00
+	Hs
		348573 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00
+	Hs
		833596 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00
+	Hs
		833561 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00
+	Hs
		833569 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00
+	Hs
		349776 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55
+	Hs
		349044 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55
+	Hs
		1070492 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55
+	Hs
		350748 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55
+	Mm
		1206680 RAB1B_MOUSE (4-187): 1.74e-73: 221: 31.96		ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75
+	Hs
		914507 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55
+	Hs
		350414 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49
+	Hs
		253561 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		CAPON_HUMAN (8-286): 2.51e-35: 141: 17.11
+	Hs
		253519 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		CAPON_HUMAN (8-286): 2.51e-35: 141: 17.11
+	Hs
		297805 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		K0754_HUMAN (163-529): 9.31e-23: 106: 12.00
+	Hs
		297829 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		K0754_HUMAN (163-529): 9.31e-23: 106: 12.00
+	Hs
		297806 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		K0754_HUMAN (163-529): 9.31e-23: 106: 12.00
+	Hs
		253530 RALA_HUMAN (4-169): 5.37e-58: 182: 53.29		CAPON_HUMAN (8-286): 2.51e-35: 141: 17.11