Protein: HIBCH
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H)

Gene: HIBCH
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q6NVY1

Gene Ontology (top 5):
GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006574 - L-valine catabolic process
GO:0009083 - branched-chain amino acid catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

888532

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

3

7

High-throughput

0.667

High

1203442

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

1239095

HIBCH
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

1

16

High-throughput

0.618

High

1239103

MKRN2
E3 ubiquitin-protein ligase makorin-2

3

1

High-throughput

0.609

High

225201

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

2

0

High-throughput

0.602

High

1162376

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

4

High-throughput

0.584

High

872438

SOX2
Transcription factor SOX-2

2

3

High-throughput

0.574

High

416026

CP1A1
Cytochrome P450 1A1

1

1

High-throughput

0.536

High

1234680

ETFR1
Electron transfer flavoprotein regulatory factor 1

1

1

High-throughput

0.536

High

1239105

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

7

High-throughput

0.536

High

591690

H2AX
Histone H2AX

1

5

High-throughput

0.489

High

1239100

DDX54
ATP-dependent RNA helicase DDX54

1

1

High-throughput

0.489

High

1239102

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

5

High-throughput

0.489

High

1239104

GSX1
GS homeobox 1

1

1

High-throughput

0.489

High

1239106

SCRT2
Transcriptional repressor scratch 2

1

3

High-throughput

0.489

High

242011

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

279797

CISY
Citrate synthase, mitochondrial

1

8

High-throughput

0.479

High

519141

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

4

High-throughput

0.479

High

532676

CH60
60 kDa heat shock protein, mitochondrial

1

5

High-throughput

0.479

High

851923

EFTS
Elongation factor Ts, mitochondrial

1

4

High-throughput

0.479

High

1058085

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

4

High-throughput

0.479

High

1142572

PDK1
[Pyruvate dehydrogenase

1

4

High-throughput

0.479

High

1239101

FAKD4
FAST kinase domain-containing protein 4

1

7

High-throughput

0.479

High

177558

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.458

High

1209281

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

474066

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.437

High

537354

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

987709

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.437

High

1026427

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.437

High

1239097

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

1239108

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.437

High

1103992

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

261198

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

330203

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

598744

ANFB
Natriuretic peptides B

1

2

High-throughput

0.407

High

708980

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.328

High

1239096

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

66361

PRR19
Proline-rich protein 19

1

0

High-throughput

0.279

Low

342441

RPP29
Ribonuclease P protein subunit p29

1

0

High-throughput

0.279

Low

611904

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.279

Low

882515

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.279

Low

1025218

HXC5
Homeobox protein Hox-C5

1

0

High-throughput

0.279

Low

1239098

CIART
Circadian-associated transcriptional repressor

1

0

High-throughput

0.279

Low

1239107

CENPM
Centromere protein M

1

0

High-throughput

0.279

Low

1239109

NP1L2
Nucleosome assembly protein 1-like 2

1

0

High-throughput

0.279

Low

1239099

FLCN
Folliculin

1

0

High-throughput

0.269

Low

377607

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025