HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: PTK7 (Q13308)
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Gene: PTK7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	30639242, 30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0030036 - actin cytoskeleton organization
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1070
+	Hs
		349286 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PTK7_HUMAN (2-329): 4.66e-52: 201: 19.94
+	Hs
		348643 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PTK7_HUMAN (2-329): 4.66e-52: 201: 19.94
+	Hs
		1070455 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ALK_HUMAN (695-1067): 1.21e-52: 204: 32.90
+	Hs
		384608 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		384613 RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		384167 RALA_HUMAN (4-169): 5.37e-58: 182: 53.29		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		507936 RAB1A_HUMAN (4-187): 7.4e-74: 222: 34.36		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Hs
		507935 RAB14_HUMAN (4-184): 3.77e-72: 218: 29.51		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Hs
		987290 RAB1B_HUMAN (4-187): 1.21e-73: 221: 32.47		TYRO3_HUMAN (226-605): 4.36e-27: 121: 13.17
+	Hs
		349346 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NTRK3_HUMAN (40-228): 3.71e-16: 85.9: 19.10
+	Hs
		507937 RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Rn
		589761 RASH_RAT (1-188): 6.53e-87: 255: 86.77		NTRK1_RAT (35-241): 4.44e-10: 65.9: 19.28
+	Hs
		350405 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		TITIN_HUMAN (2-145): 6.21e-13: 75.9: 16.22
+	Hs
		350572 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ROBO2_HUMAN (590-799): 3.13e-11: 70.1: 14.16
+	Hs
		914253 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		TITIN_HUMAN (2-145): 6.21e-13: 75.9: 16.22