HitPredict

Interactor 1: INS (P01308)
Insulin [Cleaved into: Insulin B chain; Insulin A chain]
Gene: INS

Interactor 2: IDE (P14735)
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Gene: IDE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.90	0.777

Property	Details
Experiments	29273204, 17051221
Identification Methods	x-ray crystallography, molecular sieving, protease assay
Interaction Type	association, direct interaction, protein cleavage

Property	Details
Interacting Pfam domains	Insulin~Peptidase_M16, Insulin~Peptidase_M16_C, Insulin~Peptidase_M16_M
Common GO terms	GO:0005615 - extracellular space GO:0008286 - insulin receptor signaling pathway
Homologous interactions	0