Protein: S1PR1
Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)

Gene: S1PR1
Organism: Homo sapiens
Interactions: 131
UniProt ID: P21453

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001664 - G protein-coupled receptor binding
GO:0001955 - blood vessel maturation
GO:0003245 - cardiac muscle tissue growth involved in heart morphogenesis
GO:0003376 - sphingosine-1-phosphate receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475890

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

20

Small-scale

0.740

High

638179

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

20

Small-scale

0.740

High

638174

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

20

High-throughput

0.691

High

638194

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

20

High-throughput

0.691

High

638241

TTYH3
Protein tweety homolog 3

3

11

High-throughput

0.662

High

565554

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

2

20

High-throughput

0.628

High

638176

AT12A
Potassium-transporting ATPase alpha chain 2

2

20

High-throughput

0.628

High

638186

CD47
Leukocyte surface antigen CD47

2

3

High-throughput

0.628

High

638207

GRIN1
G protein-regulated inducer of neurite outgrowth 1

2

5

High-throughput

0.628

High

638258

CLC2D
C-type lectin domain family 2 member D

2

9

High-throughput

0.628

High

477127

5HT1A
5-hydroxytryptamine receptor 1A

1

19

Small-scale

0.618

High

638172

5HT1D
5-hydroxytryptamine receptor 1D

1

17

Small-scale

0.618

High

536232

PPAL
Lysosomal acid phosphatase

3

6

High-throughput

0.604

High

334682

IPO7
Importin-7

2

13

High-throughput

0.601

High

638190

PKD2
Polycystin-2

2

1

High-throughput

0.601

High

638206

DYM
Dymeclin

2

4

High-throughput

0.601

High

638232

SORT
Sortilin

2

1

High-throughput

0.601

High

638233

TS101
Tumor susceptibility gene 101 protein

2

2

High-throughput

0.601

High

638256

SCN3B
Sodium channel regulatory subunit beta-3

1

4

High-throughput

0.575

High

219273

B4GA1
Beta-1,4-glucuronyltransferase 1

2

3

High-throughput

0.549

High

638198

MBRL
Membralin

2

5

High-throughput

0.549

High

638208

MON2
Protein MON2 homolog

2

6

High-throughput

0.549

High

638209

FRMD5
FERM domain-containing protein 5

2

5

High-throughput

0.549

High

638214

ARL10
ADP-ribosylation factor-like protein 10

2

11

High-throughput

0.549

High

638245

GLP3L
Golgi phosphoprotein 3-like

2

5

High-throughput

0.549

High

638247

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

4

High-throughput

0.549

High

638254

TM160
Transmembrane protein 160

2

3

High-throughput

0.549

High

62905

POTEF
POTE ankyrin domain family member F

1

9

High-throughput

0.536

High

125712

STXB3
Syntaxin-binding protein 3

1

4

High-throughput

0.536

High

164524

TNPO2
Transportin-2

1

7

High-throughput

0.536

High

173652

BTAF1
TATA-binding protein-associated factor 172

1

6

High-throughput

0.536

High

184116

RER1
Protein RER1

1

3

High-throughput

0.536

High

189107

IPO8
Importin-8

1

12

High-throughput

0.536

High

230751

EXTL3
Exostosin-like 3

1

3

High-throughput

0.536

High

252656

TSN3
Tetraspanin-3

1

20

High-throughput

0.536

High

349372

TSN15
Tetraspanin-15

1

20

High-throughput

0.536

High

374398

RASH
GTPase HRas

1

9

High-throughput

0.536

High

518580

RAP2A
Ras-related protein Rap-2a

1

7

High-throughput

0.536

High

557088

SRC
Proto-oncogene tyrosine-protein kinase Src

1

7

High-throughput

0.536

High

562778

CY24A
Cytochrome b-245 light chain

1

2

High-throughput

0.536

High

638180

GBG5

1

3

High-throughput

0.536

High

638181

AT2C1
Calcium-transporting ATPase type 2C member 1

1

20

High-throughput

0.536

High

638182

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

20

High-throughput

0.536

High

638184

CKAP4
Cytoskeleton-associated protein 4

1

5

High-throughput

0.536

High

638189

TMED1
Transmembrane emp24 domain-containing protein 1

1

5

High-throughput

0.536

High

638191

CKAP5
Cytoskeleton-associated protein 5

1

6

High-throughput

0.536

High

638193

ZMYM3
Zinc finger MYM-type protein 3

1

2

High-throughput

0.536

High

638197

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

20

High-throughput

0.536

High

638199

COL12
Collectin-12

1

2

High-throughput

0.536

High

638200

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

4

High-throughput

0.536

High

638201

CNNM4
Metal transporter CNNM4

1

5

High-throughput

0.536

High

638202

S39A4
Zinc transporter ZIP4

1

20

High-throughput

0.536

High

638211

GP180
Integral membrane protein GPR180

1

4

High-throughput

0.536

High

638215

VP37A
Vacuolar protein sorting-associated protein 37A

1

1

High-throughput

0.536

High

638219

TBC15
TBC1 domain family member 15

1

9

High-throughput

0.536

High

638221

LMBR1
Limb region 1 protein homolog

1

2

High-throughput

0.536

High

638226

F241B
Protein FAM241B

1

5

High-throughput

0.536

High

638228

SAAL1
Protein SAAL1

1

3

High-throughput

0.536

High

638229

IPO9
Importin-9

1

12

High-throughput

0.536

High

638230

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

9

High-throughput

0.536

High

638231

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.536

High

638235

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

5

High-throughput

0.536

High

638237

TTYH2
Protein tweety homolog 2

1

11

High-throughput

0.536

High

638239

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.536

High

638240

XPO4
Exportin-4

1

11

High-throughput

0.536

High

638242

YIPF3
Protein YIPF3

1

5

High-throughput

0.536

High

638243

T126A
Transmembrane protein 126A

1

3

High-throughput

0.536

High

638252

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

3

High-throughput

0.536

High

638255

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

5

High-throughput

0.536

High

638260

S39AA
Zinc transporter ZIP10

1

20

High-throughput

0.536

High

638261

TMCO1
Calcium load-activated calcium channel

1

2

High-throughput

0.536

High

638266

TNPO3
Transportin-3

1

17

High-throughput

0.536

High

638185

CD69
Early activation antigen CD69

1

9

Small-scale

0.515

High

208017

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.513

High

638177

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

638259

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.513

High

421494

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

186402

TM9S1
Transmembrane 9 superfamily member 1

1

12

High-throughput

0.489

High

290854

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.489

High

638178

SYJ2B
Synaptojanin-2-binding protein

1

16

High-throughput

0.489

High

638203

THADA
tRNA

1

5

High-throughput

0.489

High

638204

CERS6
Ceramide synthase 6

1

14

High-throughput

0.489

High

638210

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

5

High-throughput

0.489

High

638212

MIRO2
Mitochondrial Rho GTPase 2

1

7

High-throughput

0.489

High

638213

K2013
Uncharacterized protein KIAA2013

1

6

High-throughput

0.489

High

638220

THEM6
Protein THEM6

1

2

High-throughput

0.489

High

638222

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

4

High-throughput

0.489

High

638223

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

5

High-throughput

0.489

High

638224

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

20

High-throughput

0.489

High

638238

PTSS2
Phosphatidylserine synthase 2

1

6

High-throughput

0.489

High

638248

S38AA
Solute carrier family 38 member 10

1

3

High-throughput

0.489

High

638250

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

3

High-throughput

0.489

High

638251

TM9S3
Transmembrane 9 superfamily member 3

1

12

High-throughput

0.489

High

638253

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

3

High-throughput

0.489

High

638257

COX16
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

1

1

High-throughput

0.489

High

638262

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

2

High-throughput

0.489

High

638263

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

5

High-throughput

0.489

High

638264

TMED5
Transmembrane emp24 domain-containing protein 5

1

5

High-throughput

0.489

High

131730

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

8

Small-scale

0.479

High

464807

SP1
Transcription factor Sp1

1

1

High-throughput

0.479

High

484050

PGFRB
Platelet-derived growth factor receptor beta

1

3

Small-scale

0.479

High

638183

CAV1
Caveolin-1

1

4

Small-scale

0.479

High

638196

TRIP6
Thyroid receptor-interacting protein 6

1

2

Small-scale

0.479

High

154798

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

2

High-throughput

0.445

High

178901

SCAM2
Secretory carrier-associated membrane protein 2

1

10

High-throughput

0.445

High

323961

CSTN1
Calsyntenin-1

1

7

High-throughput

0.445

High

351076

ECD
Protein ecdysoneless homolog

1

2

High-throughput

0.445

High

351272

TTLL1
Polyglutamylase complex subunit TTLL1

1

1

High-throughput

0.445

High

638187

TRDN
Triadin

1

3

High-throughput

0.445

High

638188

S39A6
Zinc transporter ZIP6

1

20

High-throughput

0.445

High

638192

DSG2
Desmoglein-2

1

5

High-throughput

0.445

High

638195

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

3

High-throughput

0.445

High

638217

RAI3
Retinoic acid-induced protein 3

1

14

High-throughput

0.445

High

638218

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.445

High

638225

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

4

High-throughput

0.445

High

638227

TRI44
Tripartite motif-containing protein 44

1

1

High-throughput

0.445

High

638244

TTYH1
Protein tweety homolog 1

1

11

High-throughput

0.445

High

638246

GOLP3
Golgi phosphoprotein 3

1

5

High-throughput

0.445

High

638249

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

4

High-throughput

0.445

High

638267

BACE2
Beta-secretase 2

1

1

High-throughput

0.445

High

105329

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

220472

RNF13
E3 ubiquitin-protein ligase RNF13

1

0

High-throughput

0.426

High

638173

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.426

High

638216

FAD1
FAD synthase

1

0

High-throughput

0.426

High

638265

PCDGD
Protocadherin gamma-B1

1

0

High-throughput

0.426

High

350523

CF047
Uncharacterized protein C6orf47

1

1

High-throughput

0.407

High

638268

TX264
Testis-expressed protein 264

1

2

High-throughput

0.407

High

638234

CMS1
Protein CMSS1

1

0

High-throughput

0.282

High

638175

HXK3
Hexokinase-3

1

0

High-throughput

0.279

Low

638236

MIC25
MICOS complex subunit MIC25

1

0

High-throughput

0.279

Low

638205

CHST9
Carbohydrate sulfotransferase 9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025