HitPredict

Interactor 1: H2B (P02283)
Histone H2B
Gene: H2B, His2B;

Interactor 2: CID (Q9V6Q2)
Histone H3-like centromeric protein cid (CENP-A homolog) (Centromere identifier protein)
Gene: CID

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	17676993
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~Histone
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 123 Dm			1 225
+	Hs
		935171 H2B1M_HUMAN (3-123): 2.3e-49: 155: 80.49		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Hs
		617945 H2B1O_HUMAN (3-123): 3.29e-49: 154: 82.11		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Hs
		934852 H2B2F_HUMAN (3-123): 3.44e-49: 154: 81.30		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Hs
		935079 H2B1H_HUMAN (3-123): 5.28e-49: 154: 81.30		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Hs
		420820 H2B1J_HUMAN (3-123): 1.27e-48: 153: 81.30		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Hs
		707580 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Hs
		918280 H2B1C_HUMAN (3-123): 1.51e-48: 153: 81.30		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Hs
		1086294 H2B1M_HUMAN (3-123): 2.3e-49: 155: 80.49		H31T_HUMAN (91-221): 1.11e-55: 175: 29.85
+	Hs
		1086261 H2B1H_HUMAN (3-123): 5.28e-49: 154: 81.30		H31T_HUMAN (91-221): 1.11e-55: 175: 29.85
+	Hs
		1174641 H2B1M_HUMAN (3-123): 2.3e-49: 155: 80.49		H32_HUMAN (91-221): 2.49e-55: 174: 30.60
+	Hs
		952521 H2B1H_HUMAN (3-123): 5.28e-49: 154: 81.30		H33_HUMAN (91-221): 1.58e-55: 175: 30.60
+	Hs
		1157215 H2B1H_HUMAN (3-123): 5.28e-49: 154: 81.30		H3C_HUMAN (91-221): 3.86e-55: 174: 31.58
+	Hs
		1174620 H2B1H_HUMAN (3-123): 5.28e-49: 154: 81.30		H32_HUMAN (91-221): 2.49e-55: 174: 30.60
+	Hs
		420826 H2B1J_HUMAN (3-123): 1.27e-48: 153: 81.30		H33_HUMAN (91-221): 1.58e-55: 175: 30.60
+	Hs
		707587 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		H33_HUMAN (91-221): 1.58e-55: 175: 30.60
+	Hs
		918292 H2B1C_HUMAN (3-123): 1.51e-48: 153: 81.30		H33_HUMAN (91-221): 1.58e-55: 175: 30.60
+	Hs
		420847 H2B1J_HUMAN (3-123): 1.27e-48: 153: 81.30		H32_HUMAN (91-221): 2.49e-55: 174: 30.60
+	Hs
		707667 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		H32_HUMAN (91-221): 2.49e-55: 174: 30.60
+	Hs
		617934 H2B1O_HUMAN (3-123): 3.29e-49: 154: 82.11		CENPA_HUMAN (96-220): 1.01e-45: 150: 34.35
+	Hs
		707551 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		CENPA_HUMAN (96-220): 1.01e-45: 150: 34.35