HitPredict

Interactor 1: H4 (P02309)
Histone H4
Gene: HHF1

Interactor 2: SWR1 (Q05471)
Helicase SWR1 (EC 3.6.4.12) (Swi2/Snf2-related 1)
Gene: SWR1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30309918, 37968396, 21179020
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~Helicase_C, CENP-T_C~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 103 Sc			1 1514
+	Hs
		918125 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		INO80_HUMAN (210-1444): 0: 644: 23.37
+	Hs
		229352 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SMCA5_HUMAN (1033-1509): 3.54e-85: 304: 24.69
+	Hs
		918062 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD7_HUMAN (1114-1509): 6.46e-82: 301: 26.38
+	Hs
		917182 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD3_HUMAN (1017-1463): 2.27e-80: 296: 24.89
+	Hs
		917965 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD8_HUMAN (1034-1508): 5.26e-80: 295: 23.70
+	Hs
		917635 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD6_HUMAN (1034-1507): 1.98e-79: 293: 23.54
+	Hs
		917364 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD9_HUMAN (1108-1510): 5.26e-78: 288: 26.18
+	Hs
		917763 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		EP400_HUMAN (1098-1509): 2.23e-76: 284: 27.52
+	Dm
		950383 H4_DROME (18-103): 2.42e-41: 133: 90.70		ISWI_DROME (989-1510): 2.39e-78: 283: 22.95
+	Sc
		356774 H4_YEAST (1-103): 5.28e-47: 147: 100.00		ISW2_YEAST (1093-1503): 1.18e-72: 267: 25.94
+	Hs
		846914 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SMCA4_HUMAN (1036-1496): 9.82e-72: 267: 19.60
+	Hs
		917476 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SRCAP_HUMAN (282-660): 5.08e-44: 178: 14.17
+	Sc
		356248 H4_YEAST (1-103): 5.28e-47: 147: 100.00		SNF2_YEAST (1246-1416): 1.73e-34: 147: 47.43
+	Sc
		356605 H4_YEAST (1-103): 5.28e-47: 147: 100.00		INO80_YEAST (997-1198): 1.6e-22: 107: 8.53