Protein: NOP3
Serine/arginine (SR)-type shuttling mRNA binding protein NPL3 (Mitochondrial targeting suppressor 1 protein) (Nuclear polyadenylated RNA-binding protein 1) (Nuclear protein localization protein 3) (Polyadenylate-binding protein NPL3)

Gene: NOP3, NPL3
Organism: Saccharomyces cerevisiae S288C
Interactions: 236
UniProt ID: Q01560

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000993 - RNA polymerase II complex binding
GO:0003691 - double-stranded telomeric DNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1031027

NOP3
Serine/arginine

8

18

Small-scale

0.970

High

1031039

SKY1
Serine/threonine-protein kinase SKY1

7

20

Small-scale

0.963

High

757517

NCBP1
Nuclear cap-binding protein complex subunit 1

7

11

Small-scale

0.951

High

1031070

NCBP2
Nuclear cap-binding protein subunit 2

5

20

Small-scale

0.922

High

676762

GBP2
Serine/arginine

5

19

Small-scale

0.909

High

1031084

MTR10
mRNA transport regulator MTR10

4

18

Small-scale

0.893

High

1025646

NAM8
Protein NAM8

4

18

Small-scale

0.892

High

1027979

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

4

20

Small-scale

0.878

High

743547

RU1A
U1 small nuclear ribonucleoprotein A

4

1

Small-scale

0.878

High

741066

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

4

20

Small-scale

0.875

High

1031075

YRA1
RNA annealing protein YRA1

4

20

Small-scale

0.874

High

1031045

CTK1
CTD kinase subunit alpha

3

20

Small-scale

0.861

High

435294

RS3
Small ribosomal subunit protein uS3

3

5

High-throughput

0.827

High

518109

SSBP1
Single-stranded nucleic acid-binding protein

2

19

Small-scale

0.768

High

792912

ANM1
Protein arginine N-methyltransferase 1

13

7

Small-scale

0.763

High

403624

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

19

Small-scale

0.754

High

1031077

BBP
Branchpoint-bridging protein

2

15

Small-scale

0.754

High

1031086

HRP1
Nuclear polyadenylated RNA-binding protein 4

2

20

Small-scale

0.754

High

1031041

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

2

0

Small-scale

0.728

High

470576

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

Small-scale

0.716

High

1031085

MEX67
mRNA export factor MEX67

5

8

Small-scale

0.714

High

410288

RL25
Large ribosomal subunit protein uL23

2

6

Small-scale

0.694

High

739998

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

2

Small-scale

0.691

High

826371

SGN1
RNA-binding protein SGN1

1

20

High-throughput

0.691

High

1031068

HRK1
Serine/threonine-protein kinase HRK1

1

7

High-throughput

0.691

High

402091

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

4

Small-scale

0.680

High

1031032

XRN2
5'-3' exoribonuclease 2

4

12

Small-scale

0.676

High

825626

AIR1
Protein AIR1

3

14

Small-scale

0.672

High

692608

NSR1
Nuclear localization sequence-binding protein

1

20

Small-scale

0.656

High

545936

SSB1
Ribosome-associated molecular chaperone SSB1

3

9

Small-scale

0.656

High

1031080

AIR2
Protein AIR2

5

14

Small-scale

0.651

High

586004

CSK21
Casein kinase II subunit alpha

1

20

Small-scale

0.647

High

602607

PHO85
Cyclin-dependent protein kinase PHO85

1

12

Small-scale

0.647

High

815213

IF4F1
Eukaryotic initiation factor 4F subunit p150

3

16

Small-scale

0.646

High

671029

SIS1
Protein SIS1

3

2

High-throughput

0.643

High

444601

DED1
ATP-dependent RNA helicase DED1

3

9

Small-scale

0.642

High

393190

HSP82
ATP-dependent molecular chaperone HSP82

3

5

High-throughput

0.640

High

558837

CAF20
Cap-associated protein CAF20

3

2

Small-scale

0.640

High

594521

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

2

Small-scale

0.640

High

645507

XRN1
5'-3' exoribonuclease 1

3

12

Small-scale

0.640

High

674780

RS2
Small ribosomal subunit protein uS5

3

8

Small-scale

0.640

High

780846

MUD2
Splicing factor MUD2

3

1

Small-scale

0.640

High

524874

HSP71
Heat shock protein SSA1

3

7

High-throughput

0.633

High

815541

RSP5
E3 ubiquitin-protein ligase RSP5

2

18

Small-scale

0.619

High

646611

TRX1
Thioredoxin-1

1

2

High-throughput

0.618

High

652893

TRX2
Thioredoxin-2

1

1

High-throughput

0.618

High

656991

BUR1
Serine/threonine-protein kinase BUR1

1

15

Small-scale

0.618

High

676967

SRO9
RNA-binding protein SRO9

1

20

Small-scale

0.618

High

807687

HRB1
Serine/arginine

1

20

Small-scale

0.618

High

808772

NAB3
Nuclear polyadenylated RNA-binding protein 3

1

1

Small-scale

0.618

High

921604

NRD1
Protein NRD1

1

3

Small-scale

0.618

High

922172

PAP2
Poly(A) RNA polymerase protein 2

1

11

Small-scale

0.618

High

1031030

CUS1
Cold sensitive U2 snRNA suppressor 1

1

4

High-throughput

0.618

High

1031042

ARX1
Probable metalloprotease ARX1

2

3

Small-scale

0.601

High

666527

DBP2
ATP-dependent RNA helicase DBP2

2

7

Small-scale

0.600

High

1031060

SUB2
ATP-dependent RNA helicase SUB2

2

20

Small-scale

0.600

High

1031051

RU1C
U1 small nuclear ribonucleoprotein C

2

1

Small-scale

0.595

High

514781

RS18A
Small ribosomal subunit protein uS13A

2

2

High-throughput

0.584

High

689609

RS7A
Small ribosomal subunit protein eS7A

2

4

High-throughput

0.584

High

747528

RSSA1
Small ribosomal subunit protein uS2A

2

7

High-throughput

0.584

High

792194

GBLP
Small ribosomal subunit protein RACK1

2

20

High-throughput

0.584

High

802330

RS20
Small ribosomal subunit protein uS10

2

4

High-throughput

0.584

High

826752

DSN1
Kinetochore-associated protein DSN1

2

2

High-throughput

0.584

High

874473

RS12
Small ribosomal subunit protein eS12

2

2

High-throughput

0.584

High

916856

DXO
Decapping nuclease RAI1

2

1

Small-scale

0.584

High

1031028

RS15
Small ribosomal subunit protein uS19

2

7

High-throughput

0.584

High

1031061

LUC7
Protein LUC7

2

9

Small-scale

0.584

High

579912

HSC82
ATP-dependent molecular chaperone HSC82

2

5

High-throughput

0.571

High

1031059

BRE1
E3 ubiquitin-protein ligase BRE1

2

17

Small-scale

0.571

High

1031057

URN1
Pre-mRNA-splicing factor URN1

2

0

High-throughput

0.569

High

748002

SMY2
Protein SMY2

2

0

Small-scale

0.559

High

918223

SNU71
U1 small nuclear ribonucleoprotein component SNU71

2

0

Small-scale

0.559

High

874227

TRF5
Poly(A) RNA polymerase protein 1

1

11

Small-scale

0.553

High

1031074

RRP6
Exosome complex exonuclease RRP6

1

2

Small-scale

0.552

High

819536

SSB2
Ribosome-associated molecular chaperone SSB2

2

9

High-throughput

0.552

High

742198

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.536

High

918427

EIF2A
Eukaryotic translation initiation factor 2A

1

7

High-throughput

0.536

High

1031037

GCN5
Histone acetyltransferase GCN5

1

20

High-throughput

0.536

High

1031055

MAG2
E3 ubiquitin-protein ligase MAG2

1

1

High-throughput

0.536

High

383846

RS17A
Small ribosomal subunit protein eS17A

2

4

High-throughput

0.533

High

455212

RS19A
Small ribosomal subunit protein eS19A

2

7

High-throughput

0.533

High

503190

RS22A
Small ribosomal subunit protein uS8A

2

2

High-throughput

0.533

High

512597

RS6A
Small ribosomal subunit protein eS6A

2

8

High-throughput

0.533

High

513163

RS8A
Small ribosomal subunit protein eS8A

2

4

High-throughput

0.533

High

753532

RS3A1
Small ribosomal subunit protein eS1A

2

5

High-throughput

0.533

High

511691

RS23B
Small ribosomal subunit protein uS12B

1

0

High-throughput

0.517

High

806644

RIX1
Pre-rRNA-processing protein RIX1

1

1

Small-scale

0.515

High

813645

NUP60
Nucleoporin NUP60

1

1

Small-scale

0.515

High

1031029

MLP1
Protein MLP1

1

19

Small-scale

0.515

High

1031071

KEL3
Kelch repeat-containing protein 3

1

3

High-throughput

0.515

High

1031081

NOP58
Nucleolar protein 58

1

4

High-throughput

0.515

High

738900

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

7

Small-scale

0.508

High

704644

SBA1
Co-chaperone protein SBA1

1

0

Small-scale

0.504

High

750291

PRP40
Pre-mRNA-processing protein PRP40

1

6

High-throughput

0.501

High

815327

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

20

Small-scale

0.501

High

1031040

ENT5
Epsin-5

1

1

Small-scale

0.501

High

806158

NMD3
60S ribosomal export protein NMD3

1

0

Small-scale

0.493

High

1031062

NOP6
Nucleolar protein 6

1

2

High-throughput

0.489

High

667044

PCL1
PHO85 cyclin-1

1

0

Small-scale

0.480

High

849923

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.480

High

149905

RS9A
Small ribosomal subunit protein uS4A

1

8

High-throughput

0.479

High

381216

H2B1
Histone H2B.1

1

6

Small-scale

0.479

High

381601

H2B2
Histone H2B.2

1

6

Small-scale

0.479

High

382287

H4
Histone H4

1

10

Small-scale

0.479

High

436113

RS13
Small ribosomal subunit protein uS15

1

7

High-throughput

0.479

High

438756

SC160
Protein SCP160

1

20

High-throughput

0.479

High

442063

RS14A
Small ribosomal subunit protein uS11A

1

5

High-throughput

0.479

High

449166

CALM
Calmodulin

1

1

High-throughput

0.479

High

511956

RS30A
Small ribosomal subunit protein eS30A

1

2

High-throughput

0.479

High

512138

RS4A
Small ribosomal subunit protein eS4A

1

4

High-throughput

0.479

High

515308

RL35A
Large ribosomal subunit protein uL29A

1

3

High-throughput

0.479

High

577571

CYC8
General transcriptional corepressor CYC8

1

12

Small-scale

0.479

High

657969

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

1

18

Small-scale

0.479

High

661187

SPT6
Transcription elongation factor SPT6

1

1

Small-scale

0.479

High

672780

SNT1
Probable DNA-binding protein SNT1

1

3

Small-scale

0.479

High

677229

SPB1
27S pre-rRNA

1

11

High-throughput

0.479

High

678528

TAH1
TPR repeat-containing protein associated with Hsp90

1

6

Small-scale

0.479

High

679980

CDC48
Cell division control protein 48

1

9

High-throughput

0.479

High

688939

RS5
Small ribosomal subunit protein uS7

1

7

High-throughput

0.479

High

689107

RL16A
Large ribosomal subunit protein uL13A

1

5

High-throughput

0.479

High

694622

SPT5
Transcription elongation factor SPT5

1

2

Small-scale

0.479

High

707929

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

709932

BMH1
Protein BMH1

1

6

High-throughput

0.479

High

735116

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

739186

PRP19
Pre-mRNA-processing factor 19

1

14

Small-scale

0.479

High

743271

PP12
Serine/threonine-protein phosphatase PP1-2

1

13

Small-scale

0.479

High

744329

CHD1
Chromo domain-containing protein 1

1

20

Small-scale

0.479

High

750130

MRT4
Ribosome assembly factor MRT4

1

5

Small-scale

0.479

High

778485

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

779319

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.479

High

780053

EAP1
Protein EAP1

1

2

High-throughput

0.479

High

781154

SWD2
COMPASS component SWD2

1

19

Small-scale

0.479

High

796350

FL2D
Protein MUM2

1

1

Small-scale

0.479

High

806342

KOG1
Target of rapamycin complex 1 subunit KOG1

1

8

Small-scale

0.479

High

806490

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.479

High

818042

LSM4
LSM complex subunit LSM4

1

3

Small-scale

0.479

High

818262

NSA2
Ribosome biogenesis protein NSA2

1

7

High-throughput

0.479

High

820387

RIO2
Serine/threonine-protein kinase RIO2

1

9

High-throughput

0.479

High

829949

PRP17
Pre-mRNA-processing factor 17

1

18

Small-scale

0.479

High

835866

RL10
Large ribosomal subunit protein uL16

1

1

Small-scale

0.479

High

850156

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

14

High-throughput

0.479

High

863295

CTK2
CTD kinase subunit beta

1

14

Small-scale

0.479

High

863306

CTK3
CTD kinase subunit gamma

1

1

Small-scale

0.479

High

864125

LSM1
LSM1-LSM7 complex subunit LSM1

1

9

Small-scale

0.479

High

864183

ALB1
Ribosome biogenesis protein ALB1

1

1

High-throughput

0.479

High

864498

MTR4
ATP-dependent RNA helicase DOB1

1

20

Small-scale

0.479

High

865706

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

870673

RS7B
Small ribosomal subunit protein eS7B

1

4

High-throughput

0.479

High

917457

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

11

Small-scale

0.479

High

917674

LSG1
Large subunit GTPase 1

1

9

High-throughput

0.479

High

921192

THO2
THO complex subunit 2

1

16

Small-scale

0.479

High

923184

NOG2
Nucleolar GTP-binding protein 2

1

9

High-throughput

0.479

High

923854

GIS2
Zinc finger protein GIS2

1

15

High-throughput

0.479

High

924175

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

High-throughput

0.479

High

1018316

CTR9
RNA polymerase-associated protein CTR9

1

7

Small-scale

0.479

High

1031035

HOT1
High-osmolarity-induced transcription protein 1

1

1

Small-scale

0.479

High

1031036

TOM1
E3 ubiquitin-protein ligase TOM1

1

18

High-throughput

0.479

High

1031044

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.479

High

1031047

PUF6
Pumilio homology domain family member 6

1

12

Small-scale

0.479

High

1031049

RRP5
rRNA biogenesis protein RRP5

1

13

High-throughput

0.479

High

1031053

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

1031054

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.479

High

1031058

TSR1
Ribosome biogenesis protein TSR1

1

5

High-throughput

0.479

High

1031064

BUD20
Bud site selection protein 20

1

1

High-throughput

0.479

High

1031066

SGO1
Shugoshin

1

1

High-throughput

0.479

High

1031072

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

1031076

MAK21
Ribosome biogenesis protein MAK21

1

11

High-throughput

0.479

High

1031079

RUVB2
RuvB-like protein 2

1

5

High-throughput

0.479

High

700278

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

4

Small-scale

0.464

High

743779

RML2
Large ribosomal subunit protein uL2m

1

5

Small-scale

0.464

High

632107

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.458

High

632203

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

Small-scale

0.458

High

797776

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

805750

YHS7
Uncharacterized protein YHR127W

1

0

High-throughput

0.458

High

805801

NSG1
Protein NSG1

1

0

High-throughput

0.458

High

809393

STM1
Suppressor protein STM1

1

0

High-throughput

0.458

High

815379

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.458

High

816613

PXP1
2-hydroxyacyl-CoA lyase

1

0

High-throughput

0.458

High

824930

TM108
Protein TMA108

1

0

High-throughput

0.458

High

858346

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.458

High

924124

SQS1
Protein SQS1

1

0

High-throughput

0.458

High

1031033

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.458

High

1031034

IMA1
Importin subunit alpha

1

0

Small-scale

0.458

High

1031038

CWC21
Pre-mRNA-splicing factor CWC21

1

0

Small-scale

0.458

High

1031043

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

1031046

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

1031050

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

Small-scale

0.458

High

1031052

BUR2
Protein BUR2

1

0

Small-scale

0.458

High

1031056

IWS1
Transcription factor SPN1

1

0

Small-scale

0.458

High

1031063

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.458

High

1031067

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

1031073

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

866163

ENT3
Epsin-3

1

1

Small-scale

0.457

High

1031031

NU116
Nucleoporin NUP116/NSP116

1

8

Small-scale

0.457

High

727254

HS104
Heat shock protein 104

1

2

High-throughput

0.445

High

752623

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

763003

SPT7
SAGA complex subunit SPT7

1

13

High-throughput

0.445

High

811373

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

1025160

SEN1
Helicase SEN1

1

20

Small-scale

0.445

High

150187

THP2
THO complex subunit THP2

1

2

High-throughput

0.437

High

433798

RL26A
Large ribosomal subunit protein uL24A

1

12

High-throughput

0.437

High

434071

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.437

High

434635

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.437

High

435620

RS9B
Small ribosomal subunit protein uS4B

1

8

High-throughput

0.437

High

455438

RS19B
Small ribosomal subunit protein eS19B

1

7

High-throughput

0.437

High

504369

RL31A
Large ribosomal subunit protein eL31A

1

5

High-throughput

0.437

High

511843

RS24A
Small ribosomal subunit protein eS24A

1

3

High-throughput

0.437

High

513904

RS11B
Small ribosomal subunit protein uS17B

1

1

High-throughput

0.437

High

514180

RS16B
Small ribosomal subunit protein uS9B

1

12

High-throughput

0.437

High

673585

NLE1
Ribosome assembly protein 4

1

20

High-throughput

0.437

High

677528

KRR1
KRR1 small subunit processome component

1

8

High-throughput

0.437

High

812573

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

824768

MLP2
Protein MLP2

1

18

High-throughput

0.437

High

925367

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

942015

RL22B
Large ribosomal subunit protein eL22B

1

1

High-throughput

0.437

High

1025006

NUM1
Nuclear migration protein NUM1

1

4

High-throughput

0.437

High

1031048

POB3
FACT complex subunit POB3

1

4

High-throughput

0.437

High

1031069

RS10A
Small ribosomal subunit protein eS10A

1

6

High-throughput

0.437

High

1031078

DBP10
ATP-dependent RNA helicase DBP10

1

20

High-throughput

0.437

High

807257

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.426

High

812254

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

577197

SEC63
Protein translocation protein SEC63

1

6

High-throughput

0.407

High

811018

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.407

High

811140

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.407

High

823290

JEM1
DnaJ-like chaperone JEM1

1

1

High-throughput

0.407

High

823636

TCPE
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.407

High

850648

ERJ5
ER-localized J domain-containing protein 5

1

1

High-throughput

0.407

High

733818

VPS10
Vacuolar protein sorting/targeting protein VPS10

2

0

High-throughput

0.324

High

1031065

AUS1
ATP-dependent permease AUS1

1

0

High-throughput

0.261

Low

503517

RS28B
Small ribosomal subunit protein eS28B

1

0

High-throughput

0.249

Low

660512

HXT2
High-affinity glucose transporter HXT2

1

0

High-throughput

0.249

Low

739728

SPT16
FACT complex subunit SPT16

1

0

Small-scale

0.249

Low

831854

RS29A
Small ribosomal subunit protein uS14A

1

0

High-throughput

0.249

Low

1031082

RS21B
Small ribosomal subunit protein eS21B

1

0

High-throughput

0.249

Low

1031083

RS25A
Small ribosomal subunit protein eS25A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025