HitPredict

Interactor 1: CRYAB (P02511)
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Gene: CRYAB

Interactor 2: CRBA1 (P05813)
Beta-crystallin A3 [Cleaved into: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form]
Gene: CRYBA1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.634

Property	Details
Experiments	19401464, 17046756
Identification Methods	pull down, two hybrid, fluorescent resonance energy transfer, nuclear magnetic resonance, circular dichroism
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002088 - lens development in camera-type eye GO:0005212 - structural constituent of eye lens GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 175 Hs			1 215
+	Hs
		358701 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRBA1_HUMAN (1-215): 5.32e-118: 336: 100.00
+	Hs
		358733 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRBA4_HUMAN (27-215): 4.52e-97: 282: 68.25
+	Hs
		358714 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRBB3_HUMAN (11-214): 1.23e-80: 241: 42.72
+	Hs
		358985 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CRBB2_HUMAN (14-116): 3.83e-19: 83.5: 27.62
+	Hs
		358956 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CRGD_HUMAN (27-116): 4.06e-19: 82.8: 32.97
+	Hs
		358955 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CRGC_HUMAN (30-104): 9.48e-18: 78.9: 31.58
+	Hs
		358971 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CRYGS_HUMAN (119-213): 6.17e-14: 68.9: 25.26
+	Hs
		358725 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRBB2_HUMAN (14-116): 3.83e-19: 83.5: 27.62
+	Hs
		358703 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRGD_HUMAN (27-116): 4.06e-19: 82.8: 32.97
+	Hs
		358702 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRGC_HUMAN (30-104): 9.48e-18: 78.9: 31.58
+	Hs
		388287 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		CRBB2_HUMAN (14-116): 3.83e-19: 83.5: 27.62
+	Hs
		388156 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		CRGC_HUMAN (30-104): 9.48e-18: 78.9: 31.58
+	Hs
		426907 HSPB2_HUMAN (15-149): 2.86e-39: 133: 42.96		CRGC_HUMAN (30-104): 9.48e-18: 78.9: 31.58