HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	15696159, 25852190, 30021884, 31839598, 33961781, 35271311, 36931259, 16888623, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005080 - protein kinase C binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 247
+	Hs
		362231 ABL1_HUMAN (1-1130): 0: 987: 100.00		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Hs
		362252 ABL1_HUMAN (1-1130): 0: 987: 100.00		1433F_HUMAN (1-246): 2.51e-135: 382: 86.99
+	Hs
		362180 ABL1_HUMAN (1-1130): 0: 987: 100.00		1433B_HUMAN (2-247): 1.92e-109: 317: 75.40
+	Hs
		362236 ABL1_HUMAN (1-1130): 0: 987: 100.00		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59
+	Hs
		362169 ABL1_HUMAN (1-1130): 0: 987: 100.00		1433T_HUMAN (2-245): 5.55e-105: 305: 70.33
+	Hs
		362181 ABL1_HUMAN (1-1130): 0: 987: 100.00		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16
+	Hs
		840942 ABL2_HUMAN (10-1130): 0: 774: 52.53		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Hs
		840941 ABL2_HUMAN (10-1130): 0: 774: 52.53		1433G_HUMAN (1-247): 3.17e-139: 392: 100.00
+	Hs
		840951 ABL2_HUMAN (10-1130): 0: 774: 52.53		1433F_HUMAN (1-246): 2.51e-135: 382: 86.99
+	Hs
		729661 ABL2_HUMAN (10-1130): 0: 774: 52.53		1433B_HUMAN (2-247): 1.92e-109: 317: 75.40
+	Hs
		840945 ABL2_HUMAN (10-1130): 0: 774: 52.53		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59
+	Hs
		690810 ABL2_HUMAN (10-1130): 0: 774: 52.53		1433T_HUMAN (2-245): 5.55e-105: 305: 70.33
+	Hs
		730431 ABL2_HUMAN (10-1130): 0: 774: 52.53		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16
+	Hs
		440015 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Hs
		834164 CSK_HUMAN (61-500): 3.6e-155: 471: 37.72		1433G_HUMAN (1-247): 3.17e-139: 392: 100.00
+	Hs
		440020 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59
+	Hs
		439959 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		1433T_HUMAN (2-245): 5.55e-105: 305: 70.33
+	Hs
		439970 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16
+	Hs
		729657 CSK_HUMAN (61-500): 3.6e-155: 471: 37.72		1433B_HUMAN (2-247): 1.92e-109: 317: 75.40
+	Hs
		730531 BTK_HUMAN (5-501): 7.21e-156: 481: 36.56		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16