HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GRIN1 (Q7Z2K8)
G protein-regulated inducer of neurite outgrowth 1 (GRIN1)
Gene: GPRIN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1008
+	Hs
		363752 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MUC4_HUMAN (18-939): 5.67e-77: 280: 16.31
+	Hs
		1145772 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		MUC4_HUMAN (18-939): 5.67e-77: 280: 16.31
+	Hs
		411016 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		MUC4_HUMAN (18-939): 5.67e-77: 280: 16.31
+	Hs
		363465 EGFR_HUMAN (1-1210): 0: 1246: 100.00		GRIN3_HUMAN (287-1007): 2.26e-35: 146: 16.73
+	Hs
		641661 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		MUC4_HUMAN (18-939): 5.67e-77: 280: 16.31
+	Hs
		362705 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MUC1_HUMAN (305-1004): 6.1e-21: 101: 13.94
+	Hs
		363843 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TARA_HUMAN (6-993): 2.92e-19: 96.4: 7.14
+	Hs
		363641 EGFR_HUMAN (1-1210): 0: 1246: 100.00		TITIN_HUMAN (68-913): 1.98e-10: 67.4: 9.10
+	Hs
		363637 EGFR_HUMAN (1-1210): 0: 1246: 100.00		MUC16_HUMAN (18-989): 3.75e-09: 63.3: 10.26
+	Hs
		590283 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		MUC1_HUMAN (305-1004): 6.1e-21: 101: 13.94
+	Hs
		410586 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		MUC1_HUMAN (305-1004): 6.1e-21: 101: 13.94
+	Hs
		590242 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		MUC1_HUMAN (305-1004): 6.1e-21: 101: 13.94
+	Hs
		411136 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		CRBG1_HUMAN (57-965): 3.02e-09: 63.6: 16.45
+	Hs
		463997 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		GRIN1_HUMAN (1-1008): 5.16e-69: 252: 100.00
+	Hs
		710853 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		GRIN1_HUMAN (1-1008): 5.16e-69: 252: 100.00
+	Hs
		710334 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		GRIN1_HUMAN (1-1008): 5.16e-69: 252: 100.00
+	Hs
		463991 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		GRIN3_HUMAN (287-1007): 2.26e-35: 146: 16.73
+	Hs
		710849 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		GRIN3_HUMAN (287-1007): 2.26e-35: 146: 16.73
+	Hs
		710322 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		GRIN3_HUMAN (287-1007): 2.26e-35: 146: 16.73
+	Dm
		1071118 Q0KIF4_DROME (621-1017): 1.11e-113: 382: 32.07		Q9VLS7_DROME (32-1003): 1.25e-18: 94.1: 7.61