HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: FKBP3 (P38911)
Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (FK506-binding nuclear protein) (FKBP-70) (Nucleolar proline isomerase) (Proline rotamase)
Gene: FPR3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.80	0.776

Property	Details
Experiments	26217697, 15766533, 25452130, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~HSP90
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 709 Sc			1 411
+	Sc
		544446 HSC82_YEAST (1-709): 0: 973: 94.64		FKBP4_YEAST (1-410): 6.37e-110: 330: 53.16
+	Sc
		543720 HSC82_YEAST (1-709): 0: 973: 94.64		FKBP3_YEAST (1-411): 1.34e-108: 327: 100.00
+	Hs
		438136 HS90B_HUMAN (5-709): 0: 1026: 62.13		FKBP5_HUMAN (168-410): 1.69e-56: 194: 17.65
+	Hs
		111937 K9JA46_HUMAN (4-709): 0: 1015: 60.83		FKBP5_HUMAN (168-410): 1.69e-56: 194: 17.65
+	Hs
		431818 HS90A_HUMAN (4-709): 0: 1015: 60.83		FKBP5_HUMAN (168-410): 1.69e-56: 194: 17.65
+	Hs
		438089 HS90B_HUMAN (5-709): 0: 1026: 62.13		FKBP4_HUMAN (168-410): 1.05e-49: 176: 18.29
+	Hs
		111936 K9JA46_HUMAN (4-709): 0: 1015: 60.83		FKBP4_HUMAN (168-410): 1.05e-49: 176: 18.29
+	Hs
		431755 HS90A_HUMAN (4-709): 0: 1015: 60.83		FKBP4_HUMAN (168-410): 1.05e-49: 176: 18.29
+	Mm
		432409 HS90A_MOUSE (4-709): 0: 1012: 60.72		FKBP4_MOUSE (168-410): 5.08e-51: 179: 18.29
+	Hs
		259915 HS90B_HUMAN (5-709): 0: 1026: 62.13		FKBP6_HUMAN (282-411): 7.81e-40: 146: 24.81
+	Hs
		431721 HS90A_HUMAN (4-709): 0: 1015: 60.83		FKB1A_HUMAN (307-410): 4.57e-45: 153: 43.93
+	Hs
		111930 K9JA46_HUMAN (4-709): 0: 1015: 60.83		FKBP6_HUMAN (282-411): 7.81e-40: 146: 24.81
+	Hs
		259914 HS90A_HUMAN (4-709): 0: 1015: 60.83		FKBP6_HUMAN (282-411): 7.81e-40: 146: 24.81
+	Sc
		365771 HSP82_YEAST (1-709): 0: 984: 100.00		FKBP_YEAST (301-410): 2.19e-44: 151: 46.02
+	Sc
		543171 HSC82_YEAST (1-709): 0: 973: 94.64		FKBP_YEAST (301-410): 2.19e-44: 151: 46.02