Protein: UROK
Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]

Gene: UROK, PLAU
Organism: Homo sapiens
Interactions: 61
UniProt ID: P00749

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366458

PAI1
Plasminogen activator inhibitor 1

5

20

Small-scale

0.922

High

366461

GDN
Glia-derived nexin

4

20

Small-scale

0.899

High

366484

UPAR
Urokinase plasminogen activator surface receptor

6

0

Small-scale

0.895

High

366457

PAI2
Plasminogen activator inhibitor 2

2

20

Small-scale

0.799

High

366479

SLUR1
Secreted Ly-6/uPAR-related protein 1

2

3

Small-scale

0.799

High

366459

IPSP
Plasma serine protease inhibitor

2

20

Small-scale

0.778

High

366486

BTK
Tyrosine-protein kinase BTK

1

2

High-throughput

0.698

High

154788

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

9

High-throughput

0.691

High

366460

KLK1
Kallikrein-1

1

16

High-throughput

0.691

High

366490

FSTL4
Follistatin-related protein 4

1

4

High-throughput

0.691

High

366497

OIT3
Oncoprotein-induced transcript 3 protein

1

17

High-throughput

0.691

High

366456

A4
Amyloid-beta precursor protein

1

20

High-throughput

0.665

High

366450

TPA
Tissue-type plasminogen activator

1

17

Small-scale

0.647

High

366483

LRP2
Low-density lipoprotein receptor-related protein 2

1

11

Small-scale

0.647

High

366504

PDGFC
Platelet-derived growth factor C

1

18

Small-scale

0.647

High

366452

LDLR
Low-density lipoprotein receptor

1

12

High-throughput

0.618

High

366499

TX101
Testis-expressed protein 101

1

2

Small-scale

0.618

High

366506

ADA28
Disintegrin and metalloproteinase domain-containing protein 28

2

14

High-throughput

0.606

High

366485

NOTC2
Neurogenic locus notch homolog protein 2

1

16

High-throughput

0.575

High

366489

KPCD1
Serine/threonine-protein kinase D1

2

3

High-throughput

0.571

High

366451

MYC
Myc proto-oncogene protein

2

10

High-throughput

0.561

High

366464

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

2

High-throughput

0.541

High

62873

POTEF
POTE ankyrin domain family member F

1

3

High-throughput

0.536

High

342479

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

366462

CFC1
Cryptic protein

1

2

High-throughput

0.536

High

366463

PSPC
Surfactant protein C

1

4

High-throughput

0.536

High

366466

PRG2
Bone marrow proteoglycan

1

4

High-throughput

0.536

High

366468

PGFRA
Platelet-derived growth factor receptor alpha

1

5

High-throughput

0.536

High

366469

CAH6
Carbonic anhydrase 6

1

2

High-throughput

0.536

High

366477

DNSL1
Deoxyribonuclease-1-like 1

1

1

High-throughput

0.536

High

366480

MFAP4
Microfibril-associated glycoprotein 4

1

7

High-throughput

0.536

High

366487

KLRD1
Natural killer cells antigen CD94

1

4

High-throughput

0.536

High

366488

PTC1
Protein patched homolog 1

1

2

High-throughput

0.536

High

366500

CST11
Cystatin-11

1

2

High-throughput

0.536

High

366465

GILT
Gamma-interferon-inducible lysosomal thiol reductase

1

0

High-throughput

0.513

High

366496

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.513

High

366502

SDF2L
Stromal cell-derived factor 2-like protein 1

1

4

High-throughput

0.489

High

366495

SCAM5
Secretory carrier-associated membrane protein 5

1

1

High-throughput

0.481

High

362539

EGFR
Epidermal growth factor receptor

1

12

High-throughput

0.479

High

366455

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

15

High-throughput

0.479

High

366467

TIMP2
Metalloproteinase inhibitor 2

1

6

High-throughput

0.479

High

366470

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

11

High-throughput

0.479

High

366471

BASI
Basigin

1

3

High-throughput

0.479

High

366472

BMR1A
Bone morphogenetic protein receptor type-1A

1

2

High-throughput

0.479

High

366494

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

366478

CEBPG
CCAAT/enhancer-binding protein gamma

1

1

High-throughput

0.457

High

366453

CRP

1

2

High-throughput

0.445

High

366454

C1QA
Complement C1q subcomponent subunit A

1

3

High-throughput

0.445

High

366474

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

6

High-throughput

0.445

High

366475

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

2

High-throughput

0.445

High

366476

I12R1
Interleukin-12 receptor subunit beta-1

1

5

High-throughput

0.445

High

366473

PBX1
Pre-B-cell leukemia transcription factor 1

1

2

Small-scale

0.437

High

366481

PKNX1
Homeobox protein PKNOX1

1

2

Small-scale

0.437

High

366482

LCN6
Epididymal-specific lipocalin-6

1

0

High-throughput

0.426

High

366492

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.426

High

366503

GPC5C
G-protein coupled receptor family C group 5 member C

1

0

High-throughput

0.426

High

366498

MOCOS
Molybdenum cofactor sulfurase

3

0

High-throughput

0.347

High

366501

KAT8
Histone acetyltransferase KAT8

1

0

Small-scale

0.261

Low

366491

PP4R4
Serine/threonine-protein phosphatase 4 regulatory subunit 4

1

0

High-throughput

0.249

Low

366493

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

366505

IFT57
Intraflagellar transport protein 57 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025