HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PAK1 (Q13153)
Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
Gene: PAK1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.657

Property	Details
Experiments	12374744, 16452229
Identification Methods	affinity chromatography technology, enzymatic study, pull down, protein kinase assay, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006338 - chromatin remodeling and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 545
+	Mm
		103562 ESR1_MOUSE (1-595): 0: 570: 88.98		G5E884_MOUSE (1-545): 0: 553: 98.90
+	Hs
		369067 ESR1_HUMAN (1-595): 0: 599: 100.00		AKT2_HUMAN (141-544): 1.54e-138: 411: 22.52
+	Hs
		369066 ESR1_HUMAN (1-595): 0: 599: 100.00		AKT1_HUMAN (145-544): 8.19e-134: 399: 21.71
+	Hs
		368941 ESR1_HUMAN (1-595): 0: 599: 100.00		KAPCA_HUMAN (228-544): 8.55e-131: 386: 23.62
+	Hs
		1269807 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		STK26_HUMAN (262-545): 3.56e-122: 367: 43.71
+	Hs
		568575 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		KAPCA_HUMAN (228-544): 8.55e-131: 386: 23.62
+	Hs
		377129 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		AKT1_HUMAN (145-544): 8.19e-134: 399: 21.71
+	Hs
		622765 COT2_HUMAN (113-554): 1.44e-106: 328: 22.70		AKT2_HUMAN (141-544): 1.54e-138: 411: 22.52
+	Hs
		611379 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		AKT1_HUMAN (145-544): 8.19e-134: 399: 21.71
+	Hs
		622764 COT2_HUMAN (113-554): 1.44e-106: 328: 22.70		AKT1_HUMAN (145-544): 8.19e-134: 399: 21.71
+	Hs
		487911 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		AKT1_HUMAN (145-544): 8.19e-134: 399: 21.71
+	Hs
		611427 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		STK4_HUMAN (247-545): 2.66e-127: 382: 41.20
+	Hs
		611430 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		STK3_HUMAN (245-545): 7.24e-127: 381: 41.25
+	Hs
		370506 ESR1_HUMAN (1-595): 0: 599: 100.00		PAK6_HUMAN (66-233): 1.52e-14: 78.4: 20.65
+	Hs
		487170 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		AKT1_HUMAN (145-544): 8.19e-134: 399: 21.71
+	Hs
		330888 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		PAK4_HUMAN (68-270): 7.44e-14: 76.1: 18.36
+	Hs
		487784 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PAK6_HUMAN (66-233): 1.52e-14: 78.4: 20.65