Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b (Complement C3b-alpha' chain); Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3
Interactor 2: CO5 (P01031)
Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5b (Complement C5 alpha' chain)]
Gene: C5
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.41 | 1.00 | 0.647 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 11367533 |
| Identification Methods | pull down |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | A2M~A2M_BRD, A2M~A2M_recep, A2M~MG2, A2M~MG3, A2M~TED_complement, A2M_BRD~A2M_BRD, A2M_BRD~A2M_recep, A2M_BRD~MG1, A2M_BRD~MG2, A2M_BRD~MG3, A2M_BRD~MG4, A2M_recep~A2M_recep, A2M_recep~ANATO, A2M_recep~MG3, A2M_recep~NTR, A2M_recep~TED_complement, ANATO~ANATO, ANATO~C3_CUB1, C3_CUB1~MG2, C3_CUB1~NTR and 17 others
more... |
| Common GO terms | GO:0004866 - endopeptidase inhibitor activity GO:0005102 - signaling receptor binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006954 - inflammatory response and 5 others more... |
| Homologous interactions | 4 |
Homologous interactions
Color coding for hit scores 
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Last updated: 11Aug2025
