HitPredict

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b (Complement C3b-alpha' chain); Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: CO4A (P0C0L4)
Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; Complement C4b-A (Complement C4b-alpha' chain); Complement C4d-A; Complement C4 gamma chain]
Gene: C4A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

The method score is based on:

Property	Details
Experiments	37343697
Identification Methods	cross-linking study
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	A2M~A2M_BRD, A2M~A2M_recep, A2M~C4_MG1, A2M~MG2, A2M~MG3, A2M~TED_complement, A2M_BRD~A2M_BRD, A2M_BRD~A2M_recep, A2M_BRD~C4_MG1, A2M_BRD~MG2, A2M_BRD~MG3, A2M_BRD~MG4, A2M_recep~A2M_recep, A2M_recep~ANATO, A2M_recep~MG3, A2M_recep~NTR, A2M_recep~TED_complement, ANATO~ANATO, ANATO~C3_CUB1, C3_CUB1~MG2 and 22 others more... C3_CUB1~NTR, C3_CUB1~TED_complement, C3_CUB2~MG2, C3_CUB2~TED_complement, A2M_BRD~MG1, MG1~MG2, MG1~NTR, MG1~TED_complement, C4_MG1~MG2, CO4A-B_CUB_C~MG2, MG2~MG2, MG2~MG3, MG2~TED_complement, MG3~MG3, MG3~MG4, MG3~TED_complement, C4_MG1~MG4, MG4~MG4, MG4~TED_complement, C4_MG1~TED_complement, CO4A-B_CUB_C~TED_complement, TED_complement~TED_complement
Common GO terms	GO:0004866 - endopeptidase inhibitor activity GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0005886 - plasma membrane and 6 others more... GO:0006954 - inflammatory response GO:0006956 - complement activation GO:0006958 - complement activation, classical pathway GO:0070062 - extracellular exosome GO:0072562 - blood microparticle GO:2000427 - positive regulation of apoptotic cell clearance
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	1663
Hs

1	1744

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Last updated: 11Aug2025