HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: ATAD2 (Q6PL18)
ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA)
Gene: ATAD2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.701

Property	Details
Experiments	25640309, 31527615, 17998543, unassigned1953
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti bait coimmunoprecipitation, tandem affinity purification, two hybrid array
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1390
+	Hs
		1162752 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ATAD2_HUMAN (1-1390): 0: 901: 100.00
+	Hs
		369254 ESR1_HUMAN (1-595): 0: 599: 100.00		TERA_HUMAN (222-748): 9.59e-92: 317: 22.32
+	Hs
		369310 ESR1_HUMAN (1-595): 0: 599: 100.00		PRS4_HUMAN (407-654): 1.22e-48: 182: 42.02
+	Hs
		370020 ESR1_HUMAN (1-595): 0: 599: 100.00		AFG2A_HUMAN (746-1020): 5.64e-29: 127: 13.50
+	Hs
		875175 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TERA_HUMAN (222-748): 9.59e-92: 317: 22.32
+	Hs
		587145 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		TERA_HUMAN (222-748): 9.59e-92: 317: 22.32
+	Hs
		177524 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NVL_HUMAN (179-707): 1.37e-70: 257: 20.94
+	Hs
		659699 RXRB_HUMAN (144-549): 1.9e-111: 345: 27.64		TERA_HUMAN (222-748): 9.59e-92: 317: 22.32
+	Mm
		509313 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		TERA_MOUSE (222-748): 9.59e-92: 317: 22.32
+	Hs
		487929 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		TERA_HUMAN (222-748): 9.59e-92: 317: 22.32
+	Hs
		740484 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		TERA_HUMAN (222-748): 9.59e-92: 317: 22.32
+	Hs
		906889 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRS4_HUMAN (407-654): 1.22e-48: 182: 42.02
+	Hs
		1239592 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		AFG2A_HUMAN (746-1020): 5.64e-29: 127: 13.50
+	Hs
		611411 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PRS4_HUMAN (407-654): 1.22e-48: 182: 42.02
+	Hs
		740491 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		PRS4_HUMAN (407-654): 1.22e-48: 182: 42.02
+	Hs
		487267 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		TERA_HUMAN (222-748): 9.59e-92: 317: 22.32
+	Hs
		177439 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		NVL_HUMAN (179-707): 1.37e-70: 257: 20.94
+	Hs
		487292 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PRS4_HUMAN (407-654): 1.22e-48: 182: 42.02