Protein: C1S
Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain (Complement C1s subcomponent chain A); Complement C1s subcomponent light chain (Complement C1s subcomponent chain B)]

Gene: C1S
Organism: Homo sapiens
Interactions: 17
UniProt ID: P09871

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366118

C1R
Complement C1r subcomponent

7

14

Small-scale

0.962

High

486866

C1S
Complement C1s subcomponent

2

15

Small-scale

0.778

High

425210

IC1
Plasma protease C1 inhibitor

2

20

Small-scale

0.737

High

444674

CO2
Complement C2

2

17

Small-scale

0.712

High

486867

CO4A
Complement C4-A

1

7

Small-scale

0.691

High

486870

CCDC6
Coiled-coil domain-containing protein 6

3

3

High-throughput

0.609

High

486868

CO4B
Complement C4-B

1

7

Small-scale

0.575

High

486869

PKNX1
Homeobox protein PKNOX1

1

1

High-throughput

0.494

High

388603

C1QA
Complement C1q subcomponent subunit A

1

9

Small-scale

0.479

High

388942

FINC
Fibronectin

1

6

Small-scale

0.479

High

230244

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.470

High

486871

SULF2
Extracellular sulfatase Sulf-2

1

6

High-throughput

0.445

High

486873

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

4

Small-scale

0.439

High

378407

IFNG
Interferon gamma

1

0

High-throughput

0.426

High

486872

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

2

0

High-throughput

0.328

High

486874

REEP4
Receptor expression-enhancing protein 4

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025