Protein: ADA17
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)

Gene: ADA17, ADAM17
Organism: Homo sapiens
Interactions: 68
UniProt ID: P78536

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001666 - response to hypoxia
GO:0002446 - neutrophil mediated immunity
GO:0002467 - germinal center formation
GO:0002690 - positive regulation of leukocyte chemotaxis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

403857

ITB1
Integrin beta-1

2

17

Small-scale

0.768

High

158923

NCTR3
Natural cytotoxicity triggering receptor 3

1

3

High-throughput

0.691

High

944503

DLG1
Disks large homolog 1

2

12

Small-scale

0.662

High

726508

TIMP3
Metalloproteinase inhibitor 3

3

5

Small-scale

0.660

High

944504

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

4

Small-scale

0.639

High

944509

SDK2
Protein sidekick-2

2

5

High-throughput

0.628

High

944514

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

2

High-throughput

0.628

High

944522

LRRC3
Leucine-rich repeat-containing protein 3

2

5

High-throughput

0.628

High

944523

LMA2L
VIP36-like protein

2

0

High-throughput

0.602

High

591302

TNR1B
Tumor necrosis factor receptor superfamily member 1B

2

4

Small-scale

0.595

High

658887

MK01
Mitogen-activated protein kinase 1

1

5

Small-scale

0.589

High

944525

FBX6
F-box only protein 6

2

9

High-throughput

0.584

High

944532

INSL5
Insulin-like peptide INSL5

2

1

High-throughput

0.574

High

602243

CD9
CD9 antigen

2

20

Small-scale

0.570

High

671782

PDIA3
Protein disulfide-isomerase A3

1

5

Small-scale

0.561

High

182132

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

2

Small-scale

0.536

High

318362

ECEL1
Endothelin-converting enzyme-like 1

1

3

High-throughput

0.536

High

528966

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

654257

CALX
Calnexin

1

11

High-throughput

0.536

High

793637

DCC
Netrin receptor DCC

1

6

High-throughput

0.536

High

944505

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

5

High-throughput

0.536

High

944515

CLC2B
C-type lectin domain family 2 member B

1

20

High-throughput

0.536

High

944517

T106A
Transmembrane protein 106A

1

7

High-throughput

0.536

High

944524

SDF2L
Stromal cell-derived factor 2-like protein 1

1

7

High-throughput

0.536

High

944528

FBX2
F-box only protein 2

1

9

High-throughput

0.536

High

887022

DEF1
Neutrophil defensin 1

1

0

High-throughput

0.513

High

943968

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

640232

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

4

Small-scale

0.506

High

394523

A4
Amyloid-beta precursor protein

1

9

Small-scale

0.501

High

584375

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.501

High

944116

JAG1
Protein jagged-1

1

15

Small-scale

0.501

High

389452

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.489

High

824913

DNSL1
Deoxyribonuclease-1-like 1

1

2

High-throughput

0.489

High

944508

EP3A
Epididymal secretory protein E3-alpha

1

1

High-throughput

0.489

High

944516

CCL17
C-C motif chemokine 17

1

5

High-throughput

0.489

High

944526

CAH10
Carbonic anhydrase-related protein 10

1

3

High-throughput

0.489

High

129738

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

11

High-throughput

0.479

High

205264

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

268022

EED
Polycomb protein EED

1

1

Small-scale

0.479

High

351153

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

2

Small-scale

0.479

High

521861

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

522906

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.479

High

647540

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.479

High

823370

PAXI
Paxillin

1

4

Small-scale

0.479

High

844868

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.479

High

940776

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

944506

CUL3
Cullin-3

1

5

High-throughput

0.479

High

944510

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

944511

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

944512

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

944513

SNX33
Sorting nexin-33

1

20

Small-scale

0.479

High

944518

SNX18
Sorting nexin-18

1

19

Small-scale

0.479

High

944521

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

19

Small-scale

0.479

High

944529

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

20

Small-scale

0.479

High

944530

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.479

High

944531

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

18

Small-scale

0.479

High

944533

SNX9
Sorting nexin-9

1

20

Small-scale

0.479

High

390822

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

847440

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

890098

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

944507

PTC1
Protein patched homolog 1

1

0

High-throughput

0.458

High

944519

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

944520

DERL1
Derlin-1

1

0

High-throughput

0.458

High

944527

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

326052

TSN15
Tetraspanin-15

1

20

High-throughput

0.445

High

326273

TSN12
Tetraspanin-12

1

20

Small-scale

0.445

High

887804

CD81
CD81 antigen

1

20

High-throughput

0.445

High

905505

TSN5
Tetraspanin-5

1

20

High-throughput

0.445

High


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Last updated: 15 Jul 2024