Protein: MASP2
Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]

Gene: MASP2
Organism: Homo sapiens
Interactions: 20
UniProt ID: O00187

Gene Ontology (top 5):
GO:0001855 - complement component C4b binding
GO:0001867 - complement activation, lectin pathway
GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

125795

MASP2
Mannan-binding lectin serine protease 2

5

16

Small-scale

0.924

High

125803

CO4A
Complement C4-A

4

8

Small-scale

0.882

High

125804

CO4B
Complement C4-B

3

8

Small-scale

0.827

High

125806

MASP1
Mannan-binding lectin serine protease 1

2

17

Small-scale

0.789

High

125805

MBL2
Mannose-binding protein C

7

10

Small-scale

0.744

High

125808

FCN2
Ficolin-2

3

12

Small-scale

0.655

High

125801

IC1
Plasma protease C1 inhibitor

1

20

Small-scale

0.647

High

125800

CO3
Complement C3

1

8

Small-scale

0.575

High

125802

CO2
Complement C2

1

17

Small-scale

0.575

High

125809

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.553

High

125796

FCN1
Ficolin-1

1

12

Small-scale

0.515

High

125810

COL11
Collectin-11

1

10

Small-scale

0.515

High

125798

FCN3
Ficolin-3

1

12

Small-scale

0.501

High

125813

COL10
Collectin-10

1

12

Small-scale

0.479

High

125797

PITX3
Pituitary homeobox 3

1

4

Small-scale

0.437

High

125799

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

Small-scale

0.437

High

125807

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

125811

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

125812

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025