Protein: MASP1
Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]

Gene: MASP1
Organism: Homo sapiens
Interactions: 38
UniProt ID: P48740

Gene Ontology (top 5):
GO:0001867 - complement activation, lectin pathway
GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

877452

MASP1
Mannan-binding lectin serine protease 1

5

14

Small-scale

0.922

High

125806

MASP2
Mannan-binding lectin serine protease 2

2

17

Small-scale

0.789

High

539663

MBL2
Mannose-binding protein C

10

9

Small-scale

0.755

High

289310

FCN3
Ficolin-3

4

14

Small-scale

0.692

High

877458

FCN2
Ficolin-2

4

14

Small-scale

0.692

High

222033

NCK2
Cytoplasmic protein NCK2

1

6

High-throughput

0.656

High

425219

IC1
Plasma protease C1 inhibitor

1

20

Small-scale

0.647

High

877465

COL11
Collectin-11

2

11

Small-scale

0.621

High

501805

CO4A
Complement C4-A

1

7

Small-scale

0.618

High

501867

CO4B
Complement C4-B

1

7

Small-scale

0.618

High

369845

CO3
Complement C3

1

7

Small-scale

0.575

High

444679

CO2
Complement C2

1

17

Small-scale

0.575

High

641525

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

5

High-throughput

0.536

High

877457

CUL3
Cullin-3

1

4

High-throughput

0.536

High

877467

ERRFI
ERBB receptor feedback inhibitor 1

1

1

High-throughput

0.536

High

141994

FCN1
Ficolin-1

1

14

Small-scale

0.515

High

877459

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.513

High

877464

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.513

High

665243

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

2

High-throughput

0.508

High

877453

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.508

High

877455

KS6A3
Ribosomal protein S6 kinase alpha-3

1

6

High-throughput

0.508

High

877460

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.508

High

877468

KS6A6
Ribosomal protein S6 kinase alpha-6

1

4

High-throughput

0.508

High

529328

TAU
Microtubule-associated protein tau

1

5

Small-scale

0.501

High

769659

SFTPD
Pulmonary surfactant-associated protein D

1

14

Small-scale

0.501

High

228204

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

591529

H2AX
Histone H2AX

1

0

High-throughput

0.486

High

877462

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.486

High

877461

PDC6I
Programmed cell death 6-interacting protein

1

3

Small-scale

0.479

High

877466

CDK19
Cyclin-dependent kinase 19

1

2

High-throughput

0.479

High

877469

COL10
Collectin-10

1

14

Small-scale

0.479

High

665959

IBP5
Insulin-like growth factor-binding protein 5

1

3

Small-scale

0.445

High

877454

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.445

High

877463

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

1

Small-scale

0.445

High

277282

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

418008

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

877456

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025