HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	19620290, 16469706
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1273
+	Hs
		1269426 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		795604 NR4A2_HUMAN (87-544): 1.09e-105: 332: 24.52		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		487701 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		257735 ESR1_HUMAN (1-595): 0: 599: 100.00		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257814 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257740 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15