HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TAB2 (Q9NYJ8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
Gene: TAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	27992601, 22249258, 16469706
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 693
+	Hs
		370000 ESR1_HUMAN (1-595): 0: 599: 100.00		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Hs
		1269776 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		369455 ESR1_HUMAN (1-595): 0: 599: 100.00		IF4G1_HUMAN (71-521): 3.73e-21: 101: 8.28
+	Hs
		370607 ESR1_HUMAN (1-595): 0: 599: 100.00		CHD7_HUMAN (18-590): 1.32e-19: 96.3: 11.81
+	Hs
		368927 ESR1_HUMAN (1-595): 0: 599: 100.00		MUC1_HUMAN (23-434): 8.02e-18: 90.2: 8.89
+	Hs
		369213 ESR1_HUMAN (1-595): 0: 599: 100.00		SMCA2_HUMAN (127-396): 1.06e-10: 67.5: 10.22
+	Hs
		257541 ESR1_HUMAN (1-595): 0: 599: 100.00		ANR17_HUMAN (117-519): 7.6e-10: 64.7: 11.54
+	Hs
		370040 ESR1_HUMAN (1-595): 0: 599: 100.00		KMT2C_HUMAN (103-538): 1.38e-09: 63.9: 14.25
+	Hs
		369214 ESR1_HUMAN (1-595): 0: 599: 100.00		SMCA4_HUMAN (111-415): 6.46e-09: 61.7: 8.81
+	Hs
		1186078 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MICA3_HUMAN (139-605): 2.54e-25: 114: 11.18
+	Hs
		979962 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		IF4G1_HUMAN (71-521): 3.73e-21: 101: 8.28
+	Hs
		1269810 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CHD7_HUMAN (18-590): 1.32e-19: 96.3: 11.81
+	Hs
		554348 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MUC1_HUMAN (23-434): 8.02e-18: 90.2: 8.89
+	Hs
		1269843 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		YM012_HUMAN (48-495): 9.08e-17: 85.9: 10.02
+	Hs
		846832 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMCA2_HUMAN (127-396): 1.06e-10: 67.5: 10.22
+	Hs
		257677 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ANR17_HUMAN (117-519): 7.6e-10: 64.7: 11.54
+	Hs
		1270066 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PCLO_HUMAN (127-534): 1.1e-09: 64.4: 10.22
+	Hs
		1243831 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KMT2C_HUMAN (103-538): 1.38e-09: 63.9: 14.25
+	Hs
		847036 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SMCA4_HUMAN (111-415): 6.46e-09: 61.7: 8.81
+	Hs
		587141 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		SMCA4_HUMAN (111-415): 6.46e-09: 61.7: 8.81