Protein: ATF3
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)

Gene: ATF3
Organism: Homo sapiens
Interactions: 106
UniProt ID: P18847

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

429277

JUN
Transcription factor Jun

10

20

Small-scale

0.976

High

603609

JUNB
Transcription factor JunB

5

20

High-throughput

0.931

High

617125

ATF4
Cyclic AMP-dependent transcription factor ATF-4

3

16

Small-scale

0.879

High

605045

JUND
Transcription factor JunD

3

20

Small-scale

0.873

High

583446

ATF2
Cyclic AMP-dependent transcription factor ATF-2

3

19

High-throughput

0.857

High

617140

CEBPG
CCAAT/enhancer-binding protein gamma

3

20

High-throughput

0.835

High

617186

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

3

20

High-throughput

0.835

High

606194

CEBPB
CCAAT/enhancer-binding protein beta

3

20

Small-scale

0.834

High

617124

ATF3
Cyclic AMP-dependent transcription factor ATF-3

2

20

Small-scale

0.807

High

605234

ATF7
Cyclic AMP-dependent transcription factor ATF-7

2

20

High-throughput

0.799

High

617169

NF2L2
Nuclear factor erythroid 2-related factor 2

1

20

Small-scale

0.778

High

617153

TF65
Transcription factor p65

1

20

Small-scale

0.770

High

617135

CEBPA
CCAAT/enhancer-binding protein alpha

2

19

High-throughput

0.768

High

617129

DDIT3
DNA damage-inducible transcript 3 protein

10

15

Small-scale

0.759

High

617148

MDM2
E3 ubiquitin-protein ligase Mdm2

6

3

Small-scale

0.742

High

413159

P53
Cellular tumor antigen p53

5

8

Small-scale

0.729

High

340825

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

20

High-throughput

0.691

High

193328

MAFG
Transcription factor MafG

1

20

High-throughput

0.647

High

230255

CREB3
Cyclic AMP-responsive element-binding protein 3

1

20

High-throughput

0.647

High

370551

FOS
Protein c-Fos

1

20

High-throughput

0.647

High

583991

FOSL1
Fos-related antigen 1

1

19

High-throughput

0.647

High

584063

FOSL2
Fos-related antigen 2

1

20

High-throughput

0.647

High

617156

DBP
D site-binding protein

1

20

High-throughput

0.647

High

617167

CEBPE
CCAAT/enhancer-binding protein epsilon

1

20

High-throughput

0.647

High

617170

BATF
Basic leucine zipper transcriptional factor ATF-like

1

20

High-throughput

0.647

High

617192

MAFF
Transcription factor MafF

1

20

High-throughput

0.647

High

617194

MAFB
Transcription factor MafB

1

20

High-throughput

0.647

High

617147

SMAD3
Mothers against decapentaplegic homolog 3

2

17

Small-scale

0.624

High

617137

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

19

Small-scale

0.601

High

617161

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.595

High

617166

ELAV1
ELAV-like protein 1

2

6

Small-scale

0.584

High

617131

STAT3
Signal transducer and activator of transcription 3

2

18

High-throughput

0.576

High

617133

CRK
Adapter molecule crk

2

7

High-throughput

0.576

High

617175

DP13B
DCC-interacting protein 13-beta

2

1

High-throughput

0.576

High

617163

FHL2
Four and a half LIM domains protein 2

1

7

Small-scale

0.573

High

617189

HDAC6
Protein deacetylase HDAC6

1

20

Small-scale

0.573

High

186695

P73
Tumor protein p73

1

8

Small-scale

0.561

High

282919

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

20

Small-scale

0.561

High

617132

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

18

Small-scale

0.561

High

617139

PDX1
Pancreas/duodenum homeobox protein 1

1

10

Small-scale

0.561

High

617177

CBP
CREB-binding protein

1

20

Small-scale

0.561

High

617179

KAT5
Histone acetyltransferase KAT5

1

4

Small-scale

0.561

High

617184

P63
Tumor protein 63

1

8

Small-scale

0.561

High

258586

SH21A
SH2 domain-containing protein 1A

2

8

High-throughput

0.542

High

273977

CREST
Calcium-responsive transactivator

1

20

High-throughput

0.541

High

617126

FGFR3
Fibroblast growth factor receptor 3

1

9

High-throughput

0.541

High

486941

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.536

High

617128

RBTN1
Rhombotin-1

1

8

High-throughput

0.536

High

617146

TPM4
Tropomyosin alpha-4 chain

1

17

High-throughput

0.536

High

617150

MEF2A
Myocyte-specific enhancer factor 2A

1

5

High-throughput

0.536

High

617165

TEAD2
Transcriptional enhancer factor TEF-4

1

4

High-throughput

0.536

High

617188

DOK5
Docking protein 5

2

2

High-throughput

0.526

High

430601

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.518

High

488399

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

1

High-throughput

0.515

High

617141

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

617159

TADBP
TAR DNA-binding protein 43

1

17

High-throughput

0.515

High

617164

DCTN1
Dynactin subunit 1

1

11

High-throughput

0.515

High

216375

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

7

High-throughput

0.508

High

617151

ID3
DNA-binding protein inhibitor ID-3

1

1

Small-scale

0.508

High

617190

ZN212
Zinc finger protein 212

1

4

Small-scale

0.508

High

188167

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.501

High

325681

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

Small-scale

0.501

High

617142

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.501

High

617145

UBC9
SUMO-conjugating enzyme UBC9

1

8

Small-scale

0.501

High

617185

SRA1
Steroid receptor RNA activator 1

1

4

Small-scale

0.501

High

617191

DNM3L
DNA

1

7

Small-scale

0.501

High

617193

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.501

High

617130

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

617178

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

300725

KRT38
Keratin, type I cuticular Ha8

1

9

High-throughput

0.489

High

573920

MYL6B
Myosin light chain 6B

1

9

High-throughput

0.489

High

617127

EF1B
Elongation factor 1-beta

1

12

High-throughput

0.489

High

617134

CAZA2
F-actin-capping protein subunit alpha-2

1

3

High-throughput

0.489

High

617138

CAZA1
F-actin-capping protein subunit alpha-1

1

3

High-throughput

0.489

High

617155

CALD1
Caldesmon

1

13

High-throughput

0.489

High

617182

COR1B
Coronin-1B

1

13

High-throughput

0.489

High

617171

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

1

High-throughput

0.481

High

617174

UBR2
E3 ubiquitin-protein ligase UBR2

1

3

Small-scale

0.481

High

128766

MEN1
Menin

1

9

High-throughput

0.479

High

371122

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

403805

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

461128

HS90A
Heat shock protein HSP 90-alpha

1

15

High-throughput

0.479

High

468051

HS90B
Heat shock protein HSP 90-beta

1

14

High-throughput

0.479

High

538367

EGR2
E3 SUMO-protein ligase EGR2

1

8

High-throughput

0.479

High

617136

GSK3B
Glycogen synthase kinase-3 beta

1

6

Small-scale

0.479

High

617143

ACTB
Actin, cytoplasmic 1

1

4

Small-scale

0.479

High

617144

H4
Histone H4

1

10

High-throughput

0.479

High

617149

EWS
RNA-binding protein EWS

1

6

High-throughput

0.479

High

617152

ERCC6
DNA excision repair protein ERCC-6

1

20

Small-scale

0.479

High

617154

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

617157

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

617158

TP53B
TP53-binding protein 1

1

6

High-throughput

0.479

High

617160

ERCC8
DNA excision repair protein ERCC-8

1

17

Small-scale

0.479

High

617162

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

Small-scale

0.479

High

617168

SMAD2
Mothers against decapentaplegic homolog 2

1

17

Small-scale

0.479

High

617176

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.479

High

617180

HDA10
Polyamine deacetylase HDAC10

1

20

Small-scale

0.479

High

617187

SLX9
Ribosome biogenesis protein SLX9 homolog

1

1

Small-scale

0.479

High

617172

RIF1
Telomere-associated protein RIF1

1

8

High-throughput

0.457

High

617183

NUF2
Kinetochore protein Nuf2

1

7

High-throughput

0.457

High

617173

UBR1
E3 ubiquitin-protein ligase UBR1

1

3

Small-scale

0.439

High

399266

MMP1
Interstitial collagenase

1

11

Small-scale

0.437

High

469251

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

3

Small-scale

0.437

High

617181

IGS21
Immunoglobulin superfamily member 21

1

0

High-throughput

0.282

High

47303

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025