HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	31527615, 34591612, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 7388
+	Hs
		369273 ESR1_HUMAN (1-595): 0: 599: 100.00		EPIPL_HUMAN (1538-2789): 1.49e-35: 154: 13.15
+	Hs
		368926 ESR1_HUMAN (1-595): 0: 599: 100.00		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		369641 ESR1_HUMAN (1-595): 0: 599: 100.00		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		370043 ESR1_HUMAN (1-595): 0: 599: 100.00		SYNE1_HUMAN (343-1742): 3.05e-13: 80.2: 8.97
+	Hs
		369446 ESR1_HUMAN (1-595): 0: 599: 100.00		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		369420 ESR1_HUMAN (1-595): 0: 599: 100.00		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		369158 ESR1_HUMAN (1-595): 0: 599: 100.00		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		368893 ESR1_HUMAN (1-595): 0: 599: 100.00		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		369619 ESR1_HUMAN (1-595): 0: 599: 100.00		GOGB1_HUMAN (6684-7219): 2.29e-10: 70.5: 9.23
+	Hs
		369568 ESR1_HUMAN (1-595): 0: 599: 100.00		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		885285 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		EPIPL_HUMAN (1538-2789): 1.49e-35: 154: 13.15
+	Hs
		1068618 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		551794 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		993279 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ACTN3_HUMAN (5633-6111): 4.77e-17: 92.1: 12.20
+	Hs
		974119 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		164649 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		809148 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		1059246 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		GOGB1_HUMAN (6684-7219): 2.29e-10: 70.5: 9.23
+	Hs
		521591 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		1045473 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39