Protein: DNMT1
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)

Gene: DNMT1
Organism: Homo sapiens
Interactions: 227
UniProt ID: P26358

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001674 - female germ cell nucleus
GO:0003677 - DNA binding
GO:0003886 - DNA (cytosine-5-)-methyltransferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

685055

UHRF1
E3 ubiquitin-protein ligase UHRF1

21

20

Small-scale

0.990

High

685039

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

14

8

Small-scale

0.985

High

685080

DNM3B
DNA

7

9

Small-scale

0.961

High

684970

H31
Histone H3.1

6

20

Small-scale

0.930

High

685090

DNM3A
DNA

3

9

Small-scale

0.857

High

684989

TIF1B
Transcription intermediary factor 1-beta

3

7

Small-scale

0.827

High

685054

UHRF2
E3 ubiquitin-protein ligase UHRF2

3

20

Small-scale

0.827

High

316754

MTA2
Metastasis-associated protein MTA2

3

3

Small-scale

0.817

High

684990

MTA1
Metastasis-associated protein MTA1

3

3

Small-scale

0.817

High

684965

H4
Histone H4

2

7

High-throughput

0.776

High

685011

H31T
Histone H3.1t

2

20

Small-scale

0.768

High

216379

SUV91
Histone-lysine N-methyltransferase SUV39H1

2

12

Small-scale

0.754

High

240800

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.754

High

684929

DNMT1
DNA

2

11

Small-scale

0.754

High

684945

CBX5
Chromobox protein homolog 5

2

19

Small-scale

0.754

High

684998

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

13

Small-scale

0.754

High

550855

PCNA
Proliferating cell nuclear antigen

10

4

Small-scale

0.753

High

684993

HDAC1
Histone deacetylase 1

10

14

Small-scale

0.750

High

685007

EZH2
Histone-lysine N-methyltransferase EZH2

6

20

Small-scale

0.736

High

685073

HELLS
Lymphoid-specific helicase

1

20

Small-scale

0.724

High

507090

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

7

Small-scale

0.710

High

685036

HDAC2
Histone deacetylase 2

4

14

Small-scale

0.692

High

338774

CBX6
Chromobox protein homolog 6

1

20

High-throughput

0.691

High

685046

SIR1
NAD-dependent protein deacetylase sirtuin-1

3

7

Small-scale

0.686

High

486975

PARP1
Poly [ADP-ribose] polymerase 1

4

11

Small-scale

0.680

High

442599

RB
Retinoblastoma-associated protein

3

3

Small-scale

0.678

High

685081

DAXX
Death domain-associated protein 6

4

2

Small-scale

0.676

High

685035

SETD7
Histone-lysine N-methyltransferase SETD7

2

2

Small-scale

0.666

High

685040

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.665

High

507553

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.647

High

684937

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.647

High

684972

CBX1
Chromobox protein homolog 1

1

19

Small-scale

0.647

High

685083

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

8

Small-scale

0.647

High

685068

DMAP1
DNA methyltransferase 1-associated protein 1

2

1

Small-scale

0.644

High

246438

KDM1A
Lysine-specific histone demethylase 1A

3

3

Small-scale

0.640

High

259471

BRD4
Bromodomain-containing protein 4

3

15

High-throughput

0.640

High

349807

SNAI1
Zinc finger protein SNAI1

3

2

Small-scale

0.640

High

371208

MYC
Myc proto-oncogene protein

3

10

High-throughput

0.640

High

413230

P53
Cellular tumor antigen p53

3

3

Small-scale

0.640

High

685052

EHMT2
Histone-lysine N-methyltransferase EHMT2

3

20

Small-scale

0.640

High

285088

EED
Polycomb protein EED

2

17

Small-scale

0.635

High

684996

CUL4B
Cullin-4B

2

16

Small-scale

0.634

High

684976

RUNX1
Runt-related transcription factor 1

2

1

Small-scale

0.620

High

685008

DDB1
DNA damage-binding protein 1

2

5

Small-scale

0.619

High

243546

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

18

Small-scale

0.618

High

684949

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

684966

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

684973

H33
Histone H3.3

1

20

High-throughput

0.618

High

684988

CBX3
Chromobox protein homolog 3

1

19

High-throughput

0.618

High

685012

H2A2C
Histone H2A type 2-C

1

12

Small-scale

0.618

High

685078

CXXC1
CXXC-type zinc finger protein 1

1

7

Small-scale

0.618

High

684939

CTNB1
Catenin beta-1

2

9

Small-scale

0.611

High

684967

1433Z
14-3-3 protein zeta/delta

2

15

High-throughput

0.611

High

684936

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.604

High

684943

STAT3
Signal transducer and activator of transcription 3

2

2

Small-scale

0.601

High

685049

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

2

Small-scale

0.597

High

684947

NRIP1
Nuclear receptor-interacting protein 1

1

2

Small-scale

0.586

High

685048

DCAF5
DDB1- and CUL4-associated factor 5

1

8

Small-scale

0.586

High

684948

NR2C2
Nuclear receptor subfamily 2 group C member 2

2

11

Small-scale

0.584

High

684994

CUL3
Cullin-3

2

16

High-throughput

0.584

High

685002

SUZ12
Polycomb protein SUZ12

2

5

Small-scale

0.584

High

685038

KAT5
Histone acetyltransferase KAT5

2

2

Small-scale

0.584

High

684963

1433E
14-3-3 protein epsilon

2

2

High-throughput

0.571

High

685079

MBD2
Methyl-CpG-binding domain protein 2

2

2

Small-scale

0.571

High

685001

PAF15
PCNA-associated factor

2

2

Small-scale

0.563

High

684954

MECP2
Methyl-CpG-binding protein 2

1

12

Small-scale

0.561

High

163052

CHK1
Serine/threonine-protein kinase Chk1

2

0

Small-scale

0.559

High

685058

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

684982

MTG8
Protein CBFA2T1

1

3

Small-scale

0.552

High

685024

BRAP
BRCA1-associated protein

1

1

Small-scale

0.552

High

279022

TRIM3
Tripartite motif-containing protein 3

1

6

High-throughput

0.541

High

684969

EF1A1
Elongation factor 1-alpha 1

1

8

High-throughput

0.541

High

685030

PHC2
Polyhomeotic-like protein 2

1

3

High-throughput

0.541

High

482325

F16P1
Fructose-1,6-bisphosphatase 1

1

0

Small-scale

0.537

High

342110

BRD1
Bromodomain-containing protein 1

1

7

Small-scale

0.536

High

684961

1433G
14-3-3 protein gamma

1

15

High-throughput

0.536

High

684980

1433F
14-3-3 protein eta

1

15

High-throughput

0.536

High

685010

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.536

High

91746

MCRI1
Mapk-regulated corepressor-interacting protein 1

1

0

High-throughput

0.518

High

226958

ENSA
Alpha-endosulfine

1

0

High-throughput

0.518

High

571878

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.518

High

684935

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.518

High

685050

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

685067

NGRN
Neugrin

1

0

High-throughput

0.518

High

71430

P20L1
PHD finger protein 20-like protein 1

1

1

Small-scale

0.515

High

684995

CUL4A
Cullin-4A

1

16

Small-scale

0.515

High

684999

LASP1
LIM and SH3 domain protein 1

1

2

Small-scale

0.512

High

684953

GSK3B
Glycogen synthase kinase-3 beta

1

9

High-throughput

0.508

High

684968

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

685084

KS6A6
Ribosomal protein S6 kinase alpha-6

1

3

High-throughput

0.508

High

684931

1433T
14-3-3 protein theta

1

15

High-throughput

0.501

High

684952

RGS6
Regulator of G-protein signaling 6

1

2

Small-scale

0.501

High

684959

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

685037

KAT2B
Histone acetyltransferase KAT2B

1

13

Small-scale

0.501

High

282672

E2F6
Transcription factor E2F6

1

3

Small-scale

0.481

High

684955

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

0

Small-scale

0.480

High

142842

NFIB
Nuclear factor 1 B-type

1

9

High-throughput

0.479

High

171837

ZN263
Zinc finger protein 263

1

1

Small-scale

0.479

High

188178

HDAC3
Histone deacetylase 3

1

11

Small-scale

0.479

High

217852

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

254332

CC14B
Dual specificity protein phosphatase CDC14B

1

4

High-throughput

0.479

High

274474

DNJB6
DnaJ homolog subfamily B member 6

1

5

High-throughput

0.479

High

278242

NCOR1
Nuclear receptor corepressor 1

1

8

High-throughput

0.479

High

334509

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

9

Small-scale

0.479

High

352079

MBD3
Methyl-CpG-binding domain protein 3

1

2

Small-scale

0.479

High

400303

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

405807

MYCN
N-myc proto-oncogene protein

1

9

Small-scale

0.479

High

411387

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

445745

ENOA
Alpha-enolase

1

4

High-throughput

0.479

High

464821

SP1
Transcription factor Sp1

1

9

Small-scale

0.479

High

473796

NFIC
Nuclear factor 1 C-type

1

11

High-throughput

0.479

High

488407

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

1

Small-scale

0.479

High

534663

BIP
Endoplasmic reticulum chaperone BiP

1

13

Small-scale

0.479

High

536539

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.479

High

557874

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.479

High

559725

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

11

Small-scale

0.479

High

587958

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

606254

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

624477

WT1
Wilms tumor protein

1

14

Small-scale

0.479

High

664640

CCND1
G1/S-specific cyclin-D1

1

1

High-throughput

0.479

High

667535

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.479

High

674079

BRD2
Bromodomain-containing protein 2

1

17

High-throughput

0.479

High

684930

PAX6
Paired box protein Pax-6

1

6

Small-scale

0.479

High

684932

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

684933

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

684938

HSP74
Heat shock 70 kDa protein 4

1

8

Small-scale

0.479

High

684940

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

684941

BASI
Basigin

1

1

High-throughput

0.479

High

684942

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

684944

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

684946

YAP1
Transcriptional coactivator YAP1

1

7

High-throughput

0.479

High

684951

CEBPD
CCAAT/enhancer-binding protein delta

1

11

Small-scale

0.479

High

684956

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

684957

CTBP2
C-terminal-binding protein 2

1

3

High-throughput

0.479

High

684960

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

684962

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

684964

RUXG
Small nuclear ribonucleoprotein G

1

1

Small-scale

0.479

High

684971

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

Small-scale

0.479

High

684974

VIGLN
Vigilin

1

6

High-throughput

0.479

High

684975

CDK5
Cyclin-dependent kinase 5

1

8

Small-scale

0.479

High

684977

RELB
Transcription factor RelB

1

4

Small-scale

0.479

High

684978

SP3
Transcription factor Sp3

1

11

Small-scale

0.479

High

684979

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

1

Small-scale

0.479

High

684981

UBE3A
Ubiquitin-protein ligase E3A

1

5

High-throughput

0.479

High

684983

RBBP4
Histone-binding protein RBBP4

1

8

Small-scale

0.479

High

684984

EP300
Histone acetyltransferase p300

1

11

High-throughput

0.479

High

684986

NFIA
Nuclear factor 1 A-type

1

11

High-throughput

0.479

High

684987

NFX1
Transcriptional repressor NF-X1

1

3

High-throughput

0.479

High

684991

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

684992

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

684997

HIC1
Hypermethylated in cancer 1 protein

1

4

Small-scale

0.479

High

685000

NFIX
Nuclear factor 1 X-type

1

13

High-throughput

0.479

High

685003

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

685004

DPOD3
DNA polymerase delta subunit 3

1

1

Small-scale

0.479

High

685005

BRD3
Bromodomain-containing protein 3

1

14

High-throughput

0.479

High

685009

RBBP7
Histone-binding protein RBBP7

1

8

Small-scale

0.479

High

685013

CDKL4
Cyclin-dependent kinase-like 4

1

8

High-throughput

0.479

High

685017

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

685020

BCOR
BCL-6 corepressor

1

20

Small-scale

0.479

High

685021

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

685022

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

685025

KAISO
Transcriptional regulator Kaiso

1

3

Small-scale

0.479

High

685027

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

685031

SMC5
Structural maintenance of chromosomes protein 5

1

13

High-throughput

0.479

High

685041

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

685043

MRTFA
Myocardin-related transcription factor A

1

3

Small-scale

0.479

High

685045

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

685053

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

8

High-throughput

0.479

High

685060

WWTR1
WW domain-containing transcription regulator protein 1

1

7

High-throughput

0.479

High

685064

NSUN3
tRNA

1

1

High-throughput

0.479

High

685066

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

19

Small-scale

0.479

High

685069

BRD7
Bromodomain-containing protein 7

1

10

High-throughput

0.479

High

685070

ANLN
Anillin

1

2

High-throughput

0.479

High

685071

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.479

High

685074

ZFP57
Zinc finger protein 57 homolog

1

3

Small-scale

0.479

High

685075

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

685076

DJC27
DnaJ homolog subfamily C member 27

1

4

High-throughput

0.479

High

685077

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.479

High

685082

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

685086

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

685088

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

685089

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

164796

UN13B
Protein unc-13 homolog B

1

0

High-throughput

0.458

High

335430

SLU7
Pre-mRNA-splicing factor SLU7

1

0

Small-scale

0.458

High

573753

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

665232

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

Small-scale

0.458

High

684934

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

Small-scale

0.458

High

684958

CSN2
COP9 signalosome complex subunit 2

1

0

Small-scale

0.458

High

684985

TROP
Trophinin

1

0

High-throughput

0.458

High

685006

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

Small-scale

0.458

High

685026

RN180
E3 ubiquitin-protein ligase RNF180

1

0

Small-scale

0.458

High

685029

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

685047

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

685056

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.458

High

685057

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.458

High

685061

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.458

High

429333

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

685014

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

685028

STING
Stimulator of interferon genes protein

1

1

Small-scale

0.445

High

685059

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

49078

BLT3B
Bridge-like lipid transfer protein family member 3B

1

1

Small-scale

0.437

High

318626

RHBT1
Rho-related BTB domain-containing protein 1

1

11

High-throughput

0.437

High

482673

SPRC
SPARC

1

2

Small-scale

0.437

High

685015

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.437

High

685016

BLT3A
Bridge-like lipid transfer protein family member 3A

1

1

Small-scale

0.437

High

685023

MYH14
Myosin-14

1

5

High-throughput

0.437

High

685033

DJB14
DnaJ homolog subfamily B member 14

1

6

High-throughput

0.437

High

685042

ARL11
ADP-ribosylation factor-like protein 11

1

4

High-throughput

0.437

High

685044

SH3K1
SH3 domain-containing kinase-binding protein 1

1

5

High-throughput

0.437

High

685062

DJC25
DnaJ homolog subfamily C member 25

1

5

High-throughput

0.437

High

685063

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

685065

DJC18
DnaJ homolog subfamily C member 18

1

6

High-throughput

0.437

High

685085

HECD1
E3 ubiquitin-protein ligase HECTD1

1

9

High-throughput

0.437

High

685087

DJC16
DnaJ homolog subfamily C member 16

1

8

High-throughput

0.437

High

684950

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

354545

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.407

High

619509

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.407

High

685072

PICK1
PRKCA-binding protein

1

0

High-throughput

0.304

High

66870

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

685034

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

646764

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.249

Low

685018

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

685019

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

685032

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

230161

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.232

Low

685051

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025