HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: HSP76 (P17066)
Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6)
Gene: HSPA6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	31980649, unassigned2173, 37045861
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0019899 - enzyme binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 643
+	Hs
		374331 RAF1_HUMAN (1-648): 0: 652: 100.00		Q53FC7_HUMAN (1-643): 0: 965: 99.22
+	Hs
		373593 RAF1_HUMAN (1-648): 0: 652: 100.00		HSP7C_HUMAN (4-615): 0: 940: 79.25
+	Hs
		542812 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HSP76_HUMAN (1-643): 0: 970: 100.00
+	Hs
		488563 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		HSP76_HUMAN (1-643): 0: 970: 100.00
+	Hs
		503368 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HSP7C_HUMAN (4-615): 0: 940: 79.25
+	Mm
		655941 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		HSP7C_MOUSE (4-615): 0: 939: 79.25
+	Hs
		488545 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		HSP7C_HUMAN (4-615): 0: 940: 79.25
+	Gg
		251126 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		HSP7C_CHICK (4-615): 0: 931: 78.76
+	Hs
		503340 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		HSP7C_HUMAN (4-615): 0: 940: 79.25
+	Hs
		433227 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		HSP7C_HUMAN (4-615): 0: 940: 79.25
+	Hs
		411965 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		HSP7C_HUMAN (4-615): 0: 940: 79.25