HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: FKBP4 (Q02790)
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
Gene: FKBP4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38496616
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 459
+	Hs
		374182 RAF1_HUMAN (1-648): 0: 652: 100.00		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		488688 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		FKBP4_HUMAN (1-459): 1.71e-150: 437: 100.00
+	Hs
		542876 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Gg
		982843 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		Q646T7_CHICK (1-448): 4.26e-136: 400: 56.25
+	Hs
		488708 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		374114 RAF1_HUMAN (1-648): 0: 652: 100.00		PPID_HUMAN (251-416): 8.47e-51: 177: 28.14
+	Hs
		118664 RAF1_HUMAN (1-648): 0: 652: 100.00		AIP_HUMAN (146-416): 1.8e-50: 176: 20.12
+	Hs
		375059 RAF1_HUMAN (1-648): 0: 652: 100.00		FKBPL_HUMAN (135-415): 6.34e-49: 172: 26.15
+	Hs
		373773 RAF1_HUMAN (1-648): 0: 652: 100.00		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		542932 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		FKBPL_HUMAN (135-415): 6.34e-49: 172: 26.15
+	Hs
		118681 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		AIP_HUMAN (146-416): 1.8e-50: 176: 20.12
+	Hs
		488716 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		FKBP8_HUMAN (26-337): 2.99e-32: 128: 18.30
+	Hs
		1034905 KSR2_HUMAN (332-623): 6.72e-43: 168: 34.43		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		118683 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		AIP_HUMAN (146-416): 1.8e-50: 176: 20.12
+	Hs
		118675 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		AIP_HUMAN (146-416): 1.8e-50: 176: 20.12
+	Hs
		118671 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		AIP_HUMAN (146-416): 1.8e-50: 176: 20.12
+	Hs
		259949 KSR2_HUMAN (332-623): 6.72e-43: 168: 34.43		FKBP6_HUMAN (5-144): 9.96e-35: 133: 32.62