Protein: RPGF4
Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)

Gene: RPGF4, RAPGEF4
Organism: Homo sapiens
Interactions: 29
UniProt ID: Q8WZA2

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1209453

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.692

High

1362103

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

7

High-throughput

0.691

High

518618

RAP2A
Ras-related protein Rap-2a

1

20

Small-scale

0.647

High

982110

RAP1A
Ras-related protein Rap-1A

1

20

Small-scale

0.647

High

1362106

SWP70
Switch-associated protein 70

2

10

High-throughput

0.628

High

927458

ATX1
Ataxin-1

2

1

High-throughput

0.620

High

1362105

DEFI6
Differentially expressed in FDCP 6 homolog

2

12

High-throughput

0.606

High

1362102

MERB1
bMERB domain-containing protein 1

2

1

High-throughput

0.590

High

1362107

RIMS2
Regulating synaptic membrane exocytosis protein 2

2

5

Small-scale

0.584

High

255143

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.546

High

249179

DSCAM
Cell adhesion molecule DSCAM

1

4

High-throughput

0.541

High

1090825

TRAF2
TNF receptor-associated factor 2

1

0

High-throughput

0.518

High

843819

HD
Huntingtin

1

1

High-throughput

0.515

High

1287863

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.513

High

272976

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.494

High

1362104

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.493

High

431202

LA
Lupus La protein

1

0

High-throughput

0.493

High

884374

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.493

High

326864

RIMB1
Peripheral-type benzodiazepine receptor-associated protein 1

1

6

High-throughput

0.481

High

138250

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

242443

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

1338300

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1067173

ABCC8
ATP-binding cassette sub-family C member 8

1

0

Small-scale

0.458

High

1337375

FXL13
F-box and leucine-rich repeat protein 13

1

0

Small-scale

0.458

High

1362108

S22A7
Solute carrier family 22 member 7

1

0

High-throughput

0.458

High

1288899

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

5

High-throughput

0.445

High

106363

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1362109

X5D7A4
Benzodiazapine receptor peripheral-associated protein 1 isoform F

1

9

High-throughput

0.417

High

1237835

RADX
RPA-related protein RADX

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025