HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: ILK (Q13418)
Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK)
Gene: ILK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	25852190, 26496610, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, Ank_2~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006468 - protein phosphorylation and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 452
+	Hs
		373520 RAF1_HUMAN (1-648): 0: 652: 100.00		LCK_HUMAN (167-449): 1.86e-109: 334: 21.99
+	Hs
		373611 RAF1_HUMAN (1-648): 0: 652: 100.00		SRC_HUMAN (173-448): 1.71e-98: 307: 24.56
+	At
		84996 F4I065_ARATH (2-643): 3.97e-172: 515: 17.03		Y5457_ARATH (3-452): 1.35e-123: 374: 15.15
+	At
		84201 Y3463_ARATH (2-632): 2.38e-162: 490: 17.35		Y2289_ARATH (4-448): 4.56e-126: 388: 15.20
+	At
		83481 Y1756_ARATH (2-631): 5.57e-161: 486: 15.78		SIRK_ARATH (9-450): 2.28e-126: 389: 15.48
+	At
		84538 Y3463_ARATH (2-632): 2.38e-162: 490: 17.35		Y4245_ARATH (9-448): 1.21e-124: 385: 14.23
+	At
		85035 RLK6_ARATH (2-643): 5.27e-165: 497: 15.87		Y5457_ARATH (3-452): 1.35e-123: 374: 15.15
+	At
		1320760 Y2451_ARATH (1-644): 5.92e-162: 488: 16.04		IOS1_ARATH (9-448): 1.54e-122: 379: 15.23
+	At
		83737 Y5189_ARATH (10-647): 2.85e-163: 492: 17.04		Y5457_ARATH (3-452): 1.35e-123: 374: 15.15
+	At
		1278238 BAK1_ARATH (77-647): 6.91e-163: 482: 17.30		Y2451_ARATH (3-448): 4.49e-124: 382: 16.25
+	At
		85058 Y3463_ARATH (2-632): 2.38e-162: 490: 17.35		Y5457_ARATH (3-452): 1.35e-123: 374: 15.15
+	At
		83506 Y1756_ARATH (2-631): 5.57e-161: 486: 15.78		RLK0_ARATH (4-448): 3.22e-122: 377: 15.83
+	At
		85063 Y2451_ARATH (1-644): 5.92e-162: 488: 16.04		Y5457_ARATH (3-452): 1.35e-123: 374: 15.15
+	At
		1278201 BAK1_ARATH (77-647): 6.91e-163: 482: 17.30		IOS1_ARATH (9-448): 1.54e-122: 379: 15.23
+	At
		84371 MEE39_ARATH (1-647): 2.66e-161: 487: 16.36		Y5457_ARATH (3-452): 1.35e-123: 374: 15.15
+	At
		1278233 BAK1_ARATH (77-647): 6.91e-163: 482: 17.30		Q9SNA0_ARATH (4-448): 1.69e-122: 376: 16.74
+	At
		85020 BAK1_ARATH (77-647): 6.91e-163: 482: 17.30		Y5457_ARATH (3-452): 1.35e-123: 374: 15.15
+	At
		221372 BAK1_ARATH (77-647): 6.91e-163: 482: 17.30		BIK1_ARATH (173-451): 5.23e-117: 349: 20.32
+	Hs
		374989 RAF1_HUMAN (1-648): 0: 652: 100.00		M3K20_HUMAN (188-451): 5.67e-26: 113: 27.99