HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: PDIA6 (Q15084)
Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)
Gene: PDIA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38496616
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 440
+	Hs
		374547 RAF1_HUMAN (1-648): 0: 652: 100.00		TXND5_HUMAN (177-431): 3.21e-41: 153: 20.37
+	Hs
		374510 RAF1_HUMAN (1-648): 0: 652: 100.00		DJC10_HUMAN (119-381): 3.95e-19: 92.3: 20.68
+	Hs
		373617 RAF1_HUMAN (1-648): 0: 652: 100.00		PDIA4_HUMAN (67-271): 1.28e-17: 87.3: 22.28
+	Hs
		412201 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		PDIA6_HUMAN (1-440): 1.21e-134: 396: 100.00
+	Hs
		374233 RAF1_HUMAN (1-648): 0: 652: 100.00		PDIA5_HUMAN (153-431): 3.2e-11: 67.2: 13.01
+	Hs
		373533 RAF1_HUMAN (1-648): 0: 652: 100.00		PDIA1_HUMAN (62-387): 6.18e-10: 63: 11.59
+	Hs
		373750 RAF1_HUMAN (1-648): 0: 652: 100.00		PDIA3_HUMAN (13-386): 9.31e-10: 62.6: 11.02
+	Hs
		423128 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		PDIA1_HUMAN (62-387): 6.18e-10: 63: 11.59
+	Hs
		423113 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		PDIA1_HUMAN (62-387): 6.18e-10: 63: 11.59
+	Hs
		522950 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		PDIA2_HUMAN (121-387): 3.82e-09: 60.7: 12.85
+	Hs
		412164 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		PDIA2_HUMAN (121-387): 3.82e-09: 60.7: 12.85