Protein: ADDA
Alpha-adducin (Erythrocyte adducin subunit alpha)

Gene: ADDA, ADD1
Organism: Homo sapiens
Interactions: 154
UniProt ID: P35611

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003779 - actin binding
GO:0005516 - calmodulin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

774027

ADDB
Beta-adducin

3

5

High-throughput

0.861

High

774124

ADDG
Gamma-adducin

2

4

High-throughput

0.811

High

464125

TPM2
Tropomyosin beta chain

1

4

High-throughput

0.691

High

774051

TPM4
Tropomyosin alpha-4 chain

1

4

High-throughput

0.691

High

774063

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

8

High-throughput

0.691

High

774082

DPPA4
Developmental pluripotency-associated protein 4

3

1

High-throughput

0.667

High

540239

SPTB1
Spectrin beta chain, erythrocytic

1

9

Small-scale

0.647

High

375240

RASK
GTPase KRas

3

20

High-throughput

0.640

High

774091

ANR29
Ankyrin repeat domain-containing protein 29

4

9

High-throughput

0.630

High

736904

GBP2
Guanylate-binding protein 2

2

3

High-throughput

0.628

High

447694

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.618

High

774056

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

9

High-throughput

0.618

High

774058

DYST
Dystonin

1

8

High-throughput

0.618

High

774041

ACTB
Actin, cytoplasmic 1

2

7

High-throughput

0.611

High

540332

LAMP1
Lysosome-associated membrane glycoprotein 1

2

4

High-throughput

0.584

High

588052

RFA2
Replication protein A 32 kDa subunit

2

4

High-throughput

0.584

High

694767

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

High-throughput

0.584

High

767548

RFA3
Replication protein A 14 kDa subunit

2

4

High-throughput

0.584

High

116931

J3KN67
Tropomyosin 3

1

4

High-throughput

0.575

High

774116

HM20A
High mobility group protein 20A

1

7

High-throughput

0.573

High

774040

TERA
Transitional endoplasmic reticulum ATPase

2

2

High-throughput

0.571

High

123614

MYO1C
Unconventional myosin-Ic

1

4

High-throughput

0.536

High

316602

ST17B
Serine/threonine-protein kinase 17B

1

7

High-throughput

0.536

High

336362

SVIL
Supervillin

1

1

High-throughput

0.536

High

470882

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.536

High

529219

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.536

High

701952

TMOD1
Tropomodulin-1

1

1

High-throughput

0.536

High

774030

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

2

High-throughput

0.536

High

774031

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.536

High

774032

NEST
Nestin

1

10

High-throughput

0.536

High

774039

DAPK1
Death-associated protein kinase 1

1

9

High-throughput

0.536

High

774049

ACTG
Actin, cytoplasmic 2

1

7

High-throughput

0.536

High

774055

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

6

High-throughput

0.536

High

774057

ANK2
Ankyrin-2

1

3

High-throughput

0.536

High

774067

MARE1
Microtubule-associated protein RP/EB family member 1

1

4

High-throughput

0.536

High

774070

INF2
Inverted formin-2

1

2

High-throughput

0.536

High

774079

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

4

High-throughput

0.536

High

774086

PIM3
Serine/threonine-protein kinase pim-3

1

1

High-throughput

0.536

High

774089

PNKD
Probable thioesterase PNKD

1

1

High-throughput

0.536

High

774093

TBCK
TBC domain-containing protein kinase-like protein

1

4

High-throughput

0.536

High

774099

CDKL2
Cyclin-dependent kinase-like 2

1

2

High-throughput

0.536

High

774052

ACTC
Actin, alpha cardiac muscle 1

1

7

High-throughput

0.515

High

384374

CRYAA
Alpha-crystallin A chain

1

5

High-throughput

0.515

High

774061

PAK1
Serine/threonine-protein kinase PAK 1

1

1

High-throughput

0.515

High

774094

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

774120

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

774125

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

High-throughput

0.513

High

774128

CAPS1
Calcium-dependent secretion activator 1

1

0

High-throughput

0.513

High

774131

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.513

High

774132

UBIA1
UbiA prenyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

774050

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

774108

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

6

High-throughput

0.508

High

651064

RFX1
MHC class II regulatory factor RFX1

1

3

Small-scale

0.506

High

443230

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.501

High

603187

KPCA
Protein kinase C alpha type

1

1

Small-scale

0.501

High

774092

ATLA2
Atlastin-2

1

3

High-throughput

0.489

High

405407

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

774112

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.486

High

269154

HSF2B
Heat shock factor 2-binding protein

1

1

High-throughput

0.481

High

774118

AIRIM
AFG2-interacting ribosome maturation factor

1

1

High-throughput

0.481

High

774122

KLH42
Kelch-like protein 42

1

3

High-throughput

0.481

High

126484

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

172515

XPO1
Exportin-1

1

5

High-throughput

0.479

High

189438

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

240912

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

299086

FLOT1
Flotillin-1

1

3

High-throughput

0.479

High

327181

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.479

High

345446

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

373805

RASN
GTPase NRas

1

20

High-throughput

0.479

High

374434

RASH
GTPase HRas

1

14

High-throughput

0.479

High

400390

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

411477

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

413311

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

463378

LYN
Tyrosine-protein kinase Lyn

1

7

High-throughput

0.479

High

555912

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

580903

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

601190

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

642666

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

710097

EPHA2
Ephrin type-A receptor 2

1

10

High-throughput

0.479

High

715457

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

731016

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

774028

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.479

High

774029

YAP1
Transcriptional coactivator YAP1

1

14

High-throughput

0.479

High

774033

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

774034

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.479

High

774035

GSK3B
Glycogen synthase kinase-3 beta

1

7

High-throughput

0.479

High

774036

CDK9
Cyclin-dependent kinase 9

1

7

High-throughput

0.479

High

774038

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

774042

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

774043

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.479

High

774044

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

774045

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

774046

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

774047

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

774048

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.479

High

774053

CXAR
Coxsackievirus and adenovirus receptor

1

5

High-throughput

0.479

High

774054

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

774059

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

774062

CUL4A
Cullin-4A

1

9

High-throughput

0.479

High

774065

RAB35
Ras-related protein Rab-35

1

5

High-throughput

0.479

High

774066

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

774068

OCLN
Occludin

1

4

High-throughput

0.479

High

774069

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

774071

AR13B
ADP-ribosylation factor-like protein 13B

1

3

High-throughput

0.479

High

774072

MIDN
Midnolin

1

1

High-throughput

0.479

High

774075

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

774078

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

774081

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

774084

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

774085

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

774090

ARL14
ADP-ribosylation factor-like protein 14

1

4

High-throughput

0.479

High

774095

RN138
E3 ubiquitin-protein ligase RNF138

1

3

High-throughput

0.479

High

774096

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

774097

HS105
Heat shock protein 105 kDa

1

2

Small-scale

0.479

High

774098

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

774101

SNX27
Sorting nexin-27

1

10

High-throughput

0.479

High

774102

FMNL2
Formin-like protein 2

1

2

High-throughput

0.479

High

774103

CIC
Protein capicua homolog

1

5

High-throughput

0.479

High

774104

RANB9
Ran-binding protein 9

1

5

High-throughput

0.479

High

774109

DNJC5
DnaJ homolog subfamily C member 5

1

7

High-throughput

0.479

High

774110

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

774111

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

774113

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

774114

E41LA
Band 4.1-like protein 4A

1

4

High-throughput

0.479

High

774115

MYO10
Unconventional myosin-X

1

3

Small-scale

0.479

High

774117

ANLN
Anillin

1

2

High-throughput

0.479

High

774123

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

774126

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

774127

XPO7
Exportin-7

1

4

High-throughput

0.479

High

774129

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.479

High

657500

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

674954

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

774037

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.458

High

774060

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

774064

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

774105

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

774121

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

254849

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

429410

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

774074

CP135
Centrosomal protein of 135 kDa

1

4

High-throughput

0.445

High

774076

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.445

High

774087

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

774106

ZBT18
Zinc finger and BTB domain-containing protein 18

1

1

High-throughput

0.445

High

774107

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

774130

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

774088

ZDH17
Palmitoyltransferase ZDHHC17

1

9

High-throughput

0.439

High

105461

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

139821

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

774073

FA78A
Protein FAM78A

1

1

High-throughput

0.437

High

774100

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.437

High

774119

ARL15
ADP-ribosylation factor-like protein 15

1

7

High-throughput

0.437

High

774080

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.426

High

774083

NUP54
Nucleoporin p54

1

0

High-throughput

0.279

Low

774077

CLC9A
C-type lectin domain family 9 member A

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025