HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: H90B3 (Q58FF7)
Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc)
Gene: HSP90AB3P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	unassigned2173, 37045861
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 597
+	Hs
		373549 RAF1_HUMAN (1-648): 0: 652: 100.00		HS90B_HUMAN (1-597): 0: 799: 75.00
+	Hs
		373543 RAF1_HUMAN (1-648): 0: 652: 100.00		HS90A_HUMAN (1-597): 0: 798: 66.67
+	Hs
		542890 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		H90B3_HUMAN (1-597): 0: 838: 100.00
+	Hs
		488742 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		H90B3_HUMAN (1-597): 0: 838: 100.00
+	Hs
		373626 RAF1_HUMAN (1-648): 0: 652: 100.00		ENPL_HUMAN (3-566): 0: 674: 37.68
+	Hs
		437860 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HS90B_HUMAN (1-597): 0: 799: 75.00
+	Hs
		431496 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HS90A_HUMAN (1-597): 0: 798: 66.67
+	Gg
		513713 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		HS90A_CHICK (1-597): 0: 796: 66.16
+	Mm
		432406 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		HS90A_MOUSE (1-597): 0: 796: 65.76
+	Hs
		437832 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		HS90B_HUMAN (1-597): 0: 799: 75.00
+	Hs
		431459 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		HS90A_HUMAN (1-597): 0: 798: 66.67
+	Hs
		432156 Q96II5_HUMAN (45-646): 9.01e-168: 494: 58.82		HS90A_HUMAN (1-597): 0: 798: 66.67
+	Dm
		365432 KRAF1_DROME (45-647): 6.35e-165: 491: 44.98		HSP83_DROME (8-597): 0: 789: 60.67
+	Mm
		435915 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		ENPL_MOUSE (3-597): 0: 681: 36.34
+	Hs
		538082 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		ENPL_HUMAN (3-566): 0: 674: 37.68
+	Hs
		488555 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		ENPL_HUMAN (3-566): 0: 674: 37.68
+	Rn
		88624 D3ZHL1_RAT (138-648): 2.7e-114: 365: 26.08		HS90A_RAT (1-597): 0: 798: 66.17
+	Gg
		435893 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		ENPL_CHICK (3-566): 0: 658: 37.39
+	Hs
		374409 RAF1_HUMAN (1-648): 0: 652: 100.00		Q6PK50_HUMAN (1-287): 6.7e-140: 411: 79.13
+	Hs
		1162518 Q96II5_HUMAN (45-646): 9.01e-168: 494: 58.82		Q6PK50_HUMAN (1-287): 6.7e-140: 411: 79.13