HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: TPM3 (P06753)
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
Gene: TPM3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	27545878
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 285
+	Hs
		377927 TNFA_HUMAN (1-233): 1.88e-111: 320: 100.00		TPM1_HUMAN (2-285): 1.36e-44: 154: 91.20
+	Hs
		377921 TNFA_HUMAN (1-233): 1.88e-111: 320: 100.00		TPM2_HUMAN (2-285): 1.41e-40: 143: 86.27
+	Hs
		378050 TNFA_HUMAN (1-233): 1.88e-111: 320: 100.00		TPM4_HUMAN (43-285): 3.76e-34: 126: 69.96
+	Rn
		415086 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		TPM1_RAT (2-285): 1.15e-44: 154: 91.55
+	Rn
		597935 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		Q63607_RAT (2-285): 5.75e-44: 152: 78.52
+	Rn
		597949 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		Q923Z2_RAT (2-285): 3.24e-42: 148: 70.78
+	Rn
		597947 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		Q91XN6_RAT (2-260): 5.34e-41: 145: 90.35
+	Rn
		597936 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		TPM3_RAT (41-285): 1.72e-36: 132: 71.43
+	Rn
		597940 TNFA_RAT (1-233): 1.52e-91: 270: 78.39		Q6AZ25_RAT (41-285): 7.52e-36: 130: 65.31