Protein: TPM4
Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)

Gene: TPM4
Organism: Homo sapiens
Interactions: 222
UniProt ID: P67936

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0001725 - stress fiber
GO:0002102 - podosome
GO:0005509 - calcium ion binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

482880

TPM1
Tropomyosin alpha-1 chain

7

17

High-throughput

0.960

High

447735

TPM3
Tropomyosin alpha-3 chain

7

15

High-throughput

0.959

High

464144

TPM2
Tropomyosin beta chain

6

17

High-throughput

0.937

High

958413

ACTZ
Alpha-centractin

2

20

High-throughput

0.754

High

772732

MYH9
Myosin-9

1

7

High-throughput

0.691

High

774051

ADDA
Alpha-adducin

1

4

High-throughput

0.691

High

995453

MY18A
Unconventional myosin-XVIIIa

1

12

High-throughput

0.691

High

995462

MYO19
Unconventional myosin-XIX

1

10

High-throughput

0.691

High

563601

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

High-throughput

0.650

High

995485

ANLN
Anillin

3

4

High-throughput

0.640

High

701970

TMOD1
Tropomodulin-1

1

6

High-throughput

0.618

High

837211

ACTY
Beta-centractin

1

20

High-throughput

0.618

High

952730

ACTB
Actin, cytoplasmic 1

1

16

High-throughput

0.618

High

667755

CDK2
Cyclin-dependent kinase 2

2

7

High-throughput

0.611

High

333319

SNAPN
SNARE-associated protein Snapin

2

3

High-throughput

0.606

High

425434

ISG15
Ubiquitin-like protein ISG15

2

7

Small-scale

0.595

High

995483

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

2

Small-scale

0.595

High

318719

RHBT1
Rho-related BTB domain-containing protein 1

2

13

High-throughput

0.584

High

995487

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

557210

SRC
Proto-oncogene tyrosine-protein kinase Src

2

2

High-throughput

0.571

High

901761

RAB9A
Ras-related protein Rab-9A

2

0

High-throughput

0.547

High

371718

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.543

High

143617

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

2

High-throughput

0.536

High

180774

TIF1A
Transcription intermediary factor 1-alpha

1

6

High-throughput

0.536

High

227167

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

17

High-throughput

0.536

High

583527

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

11

High-throughput

0.536

High

607571

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

2

High-throughput

0.536

High

617146

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

17

High-throughput

0.536

High

637446

FLNA
Filamin-A

1

6

High-throughput

0.536

High

728158

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.536

High

786531

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

8

High-throughput

0.536

High

787973

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

862798

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

7

High-throughput

0.536

High

968246

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.536

High

995427

DUS7
Dual specificity protein phosphatase 7

1

2

High-throughput

0.536

High

995438

PIM3
Serine/threonine-protein kinase pim-3

1

11

High-throughput

0.536

High

995460

VMP1
Vacuole membrane protein 1

1

8

High-throughput

0.536

High

995486

PDLI7
PDZ and LIM domain protein 7

1

11

High-throughput

0.536

High

995488

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.536

High

995500

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

3

High-throughput

0.536

High

105729

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

995469

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

0

High-throughput

0.518

High

460798

CATB
Cathepsin B

1

3

High-throughput

0.515

High

692920

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

995506

DUS12
Dual specificity protein phosphatase 12

1

3

High-throughput

0.515

High

72871

HACD1
Very-long-chain

1

0

High-throughput

0.513

High

133482

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.513

High

186198

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.513

High

567743

HEM2
Delta-aminolevulinic acid dehydratase

1

0

High-throughput

0.513

High

719310

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.513

High

882446

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.513

High

995425

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

995442

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

995490

LANC2
LanC-like protein 2

1

0

High-throughput

0.513

High

995505

ASC
Apoptosis-associated speck-like protein containing a CARD

1

0

Small-scale

0.513

High

995508

PPR3C
Protein phosphatase 1 regulatory subunit 3C

1

0

High-throughput

0.513

High

995458

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

907263

STA5B
Signal transducer and activator of transcription 5B

1

3

High-throughput

0.500

High

916079

NKX25
Homeobox protein Nkx-2.5

1

5

High-throughput

0.500

High

995406

IRF8
Interferon regulatory factor 8

1

1

High-throughput

0.500

High

995467

KLF6
Krueppel-like factor 6

1

10

High-throughput

0.500

High

995511

KLF12
Krueppel-like factor 12

1

10

High-throughput

0.500

High

995489

PHP14
14 kDa phosphohistidine phosphatase

1

0

High-throughput

0.493

High

995418

FL2D
Pre-mRNA-splicing regulator WTAP

1

2

High-throughput

0.489

High

995449

DUS19
Dual specificity protein phosphatase 19

1

3

High-throughput

0.489

High

995455

ESR2
Estrogen receptor beta

1

9

Small-scale

0.489

High

995470

HDAC8
Histone deacetylase 8

1

6

High-throughput

0.489

High

995478

DUS21
Dual specificity protein phosphatase 21

1

2

High-throughput

0.489

High

995482

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.489

High

995496

CFA97
Cilia- and flagella-associated protein 97

1

2

High-throughput

0.489

High

277342

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.488

High

995423

TRIP6
Thyroid receptor-interacting protein 6

1

11

Small-scale

0.481

High

995481

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

2

Small-scale

0.481

High

126541

RHOD
Rho-related GTP-binding protein RhoD

1

10

High-throughput

0.479

High

157221

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

178243

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

188857

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

239809

PCDH7
Protocadherin-7

1

2

High-throughput

0.479

High

241356

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

245454

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

4

High-throughput

0.479

High

269483

PLCH2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

1

2

High-throughput

0.479

High

272642

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

13

High-throughput

0.479

High

276294

HMMR
Hyaluronan mediated motility receptor

1

20

High-throughput

0.479

High

323307

TRI37
E3 ubiquitin-protein ligase TRIM37

1

12

High-throughput

0.479

High

325782

UBR5
E3 ubiquitin-protein ligase UBR5

1

4

High-throughput

0.479

High

326548

MFN2
Mitofusin-2

1

1

High-throughput

0.479

High

352701

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

1

High-throughput

0.479

High

363113

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

365359

PGK1
Phosphoglycerate kinase 1

1

1

High-throughput

0.479

High

370627

FOS
Protein c-Fos

1

12

High-throughput

0.479

High

400632

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

411720

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

413593

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

459266

CATL1
Procathepsin L

1

3

High-throughput

0.479

High

464900

SP1
Transcription factor Sp1

1

8

Small-scale

0.479

High

488447

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

Small-scale

0.479

High

488767

FURIN
Furin

1

3

High-throughput

0.479

High

519932

ANDR
Androgen receptor

1

9

High-throughput

0.479

High

559925

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

2

High-throughput

0.479

High

560359

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

599190

IL7RA
Interleukin-7 receptor subunit alpha

1

1

High-throughput

0.479

High

606605

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

629766

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

830538

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

837542

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.479

High

866641

CAZA2
F-actin-capping protein subunit alpha-2

1

5

High-throughput

0.479

High

867032

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.479

High

887952

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

897224

CDK7
Cyclin-dependent kinase 7

1

7

High-throughput

0.479

High

897727

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.479

High

904574

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

907370

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

930672

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

6

High-throughput

0.479

High

962703

RND3
Rho-related GTP-binding protein RhoE

1

11

High-throughput

0.479

High

970301

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

988262

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.479

High

995407

RON
Macrophage-stimulating protein receptor

1

2

High-throughput

0.479

High

995408

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

995409

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

995410

TRI26
Tripartite motif-containing protein 26

1

4

Small-scale

0.479

High

995414

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

16

High-throughput

0.479

High

995415

SCRB2
Lysosome membrane protein 2

1

3

High-throughput

0.479

High

995417

CUL7
Cullin-7

1

1

High-throughput

0.479

High

995419

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

995420

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

995421

EEA1
Early endosome antigen 1

1

9

High-throughput

0.479

High

995422

MED1
Mediator of RNA polymerase II transcription subunit 1

1

6

High-throughput

0.479

High

995424

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.479

High

995428

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

995430

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

995431

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

995432

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

5

High-throughput

0.479

High

995433

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

995434

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

4

High-throughput

0.479

High

995436

RHOU
Rho-related GTP-binding protein RhoU

1

12

High-throughput

0.479

High

995437

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

995440

S35F2
Solute carrier family 35 member F2

1

1

Small-scale

0.479

High

995447

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.479

High

995450

ASB11
Ankyrin repeat and SOCS box protein 11

1

3

High-throughput

0.479

High

995452

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

995454

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

14

High-throughput

0.479

High

995456

RYR2
Ryanodine receptor 2

1

3

High-throughput

0.479

High

995459

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

995461

AURKB
Aurora kinase B

1

9

High-throughput

0.479

High

995463

RHOV
Rho-related GTP-binding protein RhoV

1

12

High-throughput

0.479

High

995472

RHBT2
Rho-related BTB domain-containing protein 2

1

14

High-throughput

0.479

High

995474

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.479

High

995476

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

3

High-throughput

0.479

High

995479

ECT2
Protein ECT2

1

4

High-throughput

0.479

High

995480

RHOF
Rho-related GTP-binding protein RhoF

1

10

High-throughput

0.479

High

995491

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

High-throughput

0.479

High

995493

FAT2
Protocadherin Fat 2

1

1

High-throughput

0.479

High

995497

RRBP1
Ribosome-binding protein 1

1

14

High-throughput

0.479

High

995498

HDAC6
Protein deacetylase HDAC6

1

6

High-throughput

0.479

High

995499

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

995502

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

995504

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.479

High

995509

AKT3
RAC-gamma serine/threonine-protein kinase

1

7

High-throughput

0.479

High

680688

CATS
Cathepsin S

1

3

High-throughput

0.470

High

515947

SIM17
Small integral membrane protein 17

1

0

High-throughput

0.458

High

536937

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

583274

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

621466

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

873938

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.458

High

884310

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

929888

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

995435

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

995439

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.458

High

995457

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

995471

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

995484

RTN4
Reticulon-4

1

0

High-throughput

0.458

High

249338

ZIC3
Zinc finger protein ZIC 3

1

4

High-throughput

0.457

High

725234

TLX1
T-cell leukemia homeobox protein 1

1

2

High-throughput

0.457

High

837033

ELK3
ETS domain-containing protein Elk-3

1

2

High-throughput

0.457

High

851505

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.457

High

944626

KLF3
Krueppel-like factor 3

1

11

High-throughput

0.457

High

995411

KLF10
Krueppel-like factor 10

1

10

High-throughput

0.457

High

125401

LEG9
Galectin-9

1

5

High-throughput

0.445

High

529590

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

765364

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.445

High

934440

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

995404

RHOG
Rho-related GTP-binding protein RhoG

1

7

Small-scale

0.445

High

995429

MF14B
Hippocampus abundant transcript-like protein 1

1

3

High-throughput

0.445

High

995441

CTL3
Choline transporter-like protein 3

1

1

High-throughput

0.445

High

995445

NCKX4
Sodium/potassium/calcium exchanger 4

1

3

High-throughput

0.445

High

995465

CEP63
Centrosomal protein of 63 kDa

1

18

High-throughput

0.445

High

995501

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

2

High-throughput

0.445

High

995448

LNX1
E3 ubiquitin-protein ligase LNX

1

4

High-throughput

0.439

High

163740

TCRG1
Transcription elongation regulator 1

1

1

Small-scale

0.437

High

218045

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

330859

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.437

High

352393

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

378050

TNFA
Tumor necrosis factor

1

9

High-throughput

0.437

High

913755

ZN131
Zinc finger protein 131

1

1

High-throughput

0.437

High

995405

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.437

High

995412

RLF
Zinc finger protein Rlf

1

4

High-throughput

0.437

High

995426

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

995443

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

2

High-throughput

0.437

High

995451

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.437

High

995473

UNK
RING finger protein unkempt homolog

1

2

High-throughput

0.437

High

995477

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.437

High

995492

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.437

High

995495

RN181
E3 ubiquitin-protein ligase RNF181

1

4

High-throughput

0.437

High

404764

PRIO
Major prion protein

1

0

High-throughput

0.426

High

995510

S45A1
Proton-associated sugar transporter A

1

0

High-throughput

0.426

High

254950

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.407

High

995413

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.407

High

995466

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.407

High

995468

KXDL1
KxDL motif-containing protein 1

1

7

High-throughput

0.407

High

995507

NAC2
Sodium/calcium exchanger 2

1

3

High-throughput

0.407

High

995416

PTCA
Protein tyrosine phosphatase receptor type C-associated protein

1

0

High-throughput

0.279

Low

995446

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.279

Low

995464

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.279

Low

995475

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

0

High-throughput

0.279

Low

286801

JERKY
Jerky protein homolog

1

0

High-throughput

0.268

Low

703116

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.261

Low

776046

SOX5
Transcription factor SOX-5

1

0

High-throughput

0.261

Low

995494

VSX1
Visual system homeobox 1

1

0

High-throughput

0.261

Low

898220

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.249

Low

995403

CBX1
Chromobox protein homolog 1

1

0

High-throughput

0.249

Low

995444

PTGR2
Prostaglandin reductase 2

1

0

High-throughput

0.249

Low

995503

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025