Protein: TPM1
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)

Gene: TPM1
Organism: Homo sapiens
Interactions: 212
UniProt ID: P09493

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0003065 - positive regulation of heart rate by epinephrine
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

464098

TPM2
Tropomyosin beta chain

10

17

Small-scale

0.973

High

482880

TPM4
Tropomyosin alpha-4 chain

7

17

High-throughput

0.960

High

447646

TPM3
Tropomyosin alpha-3 chain

7

17

High-throughput

0.956

High

482826

TNNT1
Troponin T, slow skeletal muscle

4

4

Small-scale

0.919

High

482817

TPM1
Tropomyosin alpha-1 chain

2

17

Small-scale

0.768

High

482987

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

8

20

High-throughput

0.757

High

482960

KXDL1
KxDL motif-containing protein 1

9

7

High-throughput

0.692

High

482842

MYH9
Myosin-9

1

7

High-throughput

0.691

High

482942

MY18A
Unconventional myosin-XVIIIa

1

12

High-throughput

0.691

High

482912

CROCC
Rootletin

3

11

High-throughput

0.667

High

482924

HOME1
Homer protein homolog 1

3

9

High-throughput

0.667

High

482936

DLG5
Disks large homolog 5

3

3

High-throughput

0.667

High

482947

EXOC4
Exocyst complex component 4

3

1

High-throughput

0.667

High

482954

SCLT1
Sodium channel and clathrin linker 1

3

20

High-throughput

0.667

High

482969

CNTLN
Centlein

3

9

High-throughput

0.667

High

482977

KLH21
Kelch-like protein 21

3

1

High-throughput

0.667

High

482988

NEMO
NF-kappa-B essential modulator

3

17

High-throughput

0.667

High

482881

ACTC
Actin, alpha cardiac muscle 1

1

15

High-throughput

0.665

High

482989

V9HW56
Epididymis secretory protein Li 108

1

17

High-throughput

0.665

High

482825

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

High-throughput

0.650

High

482853

TNNT2
Troponin T, cardiac muscle

1

4

Small-scale

0.647

High

482898

NUCG
Endonuclease G, mitochondrial

3

0

High-throughput

0.638

High

482926

SYCE1
Synaptonemal complex central element protein 1

3

3

High-throughput

0.630

High

243882

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

2

8

High-throughput

0.628

High

482837

TMOD1
Tropomodulin-1

1

6

High-throughput

0.618

High

482868

ACTB
Actin, cytoplasmic 1

1

15

High-throughput

0.618

High

482870

ACTZ
Alpha-centractin

1

20

High-throughput

0.618

High

482876

ACTA
Actin, aortic smooth muscle

1

15

High-throughput

0.618

High

482879

ACTG
Actin, cytoplasmic 2

1

15

High-throughput

0.618

High

482951

MYO19
Unconventional myosin-XIX

1

10

High-throughput

0.618

High

482836

1433T
14-3-3 protein theta

2

10

High-throughput

0.611

High

482967

ANLN
Anillin

2

4

High-throughput

0.611

High

482938

RUFY2
RUN and FYVE domain-containing protein 2

3

14

High-throughput

0.609

High

482946

C102A
Coiled-coil domain-containing protein 102A

3

11

High-throughput

0.609

High

482986

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

3

1

High-throughput

0.609

High

482907

CF184
Cilia- and flagella-associated protein 184

3

2

High-throughput

0.607

High

482925

FAM9C
Protein FAM9C

3

5

High-throughput

0.607

High

482875

PRS8
26S proteasome regulatory subunit 8

2

6

High-throughput

0.606

High

482935

CCHCR
Coiled-coil alpha-helical rod protein 1

2

13

High-throughput

0.606

High

482980

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

2

2

High-throughput

0.606

High

482820

TFPT
TCF3 fusion partner

2

4

High-throughput

0.597

High

482890

GOGA2
Golgin subfamily A member 2

2

17

High-throughput

0.597

High

482863

CNN1
Calponin-1

2

8

Small-scale

0.585

High

302337

RNF8
E3 ubiquitin-protein ligase RNF8

2

6

Small-scale

0.584

High

482897

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

17

High-throughput

0.584

High

166745

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

2

High-throughput

0.582

High

340283

YETS4
YEATS domain-containing protein 4

2

0

High-throughput

0.580

High

395357

ESR1
Estrogen receptor

2

13

High-throughput

0.571

High

482828

JUND
Transcription factor JunD

2

12

High-throughput

0.558

High

387693

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

2

4

High-throughput

0.553

High

333284

SNAPN
SNARE-associated protein Snapin

1

6

High-throughput

0.541

High

482917

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

10

High-throughput

0.541

High

135457

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.536

High

227158

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

18

High-throughput

0.536

High

279104

ULK1
Serine/threonine-protein kinase ULK1

1

10

High-throughput

0.536

High

482822

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.536

High

482827

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

11

High-throughput

0.536

High

482845

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

482848

PSB10
Proteasome subunit beta type-10

1

3

High-throughput

0.536

High

482861

RB27A
Ras-related protein Rab-27A

1

1

High-throughput

0.536

High

482871

RAP1B
Ras-related protein Rap-1b

1

6

High-throughput

0.536

High

482873

1433G
14-3-3 protein gamma

1

10

High-throughput

0.536

High

482923

PIM3
Serine/threonine-protein kinase pim-3

1

11

High-throughput

0.536

High

482957

PARK7
Parkinson disease protein 7

1

3

High-throughput

0.536

High

482976

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

3

High-throughput

0.536

High

482978

HSPB8
Heat shock protein beta-8

1

6

High-throughput

0.536

High

482982

EXOC7
Exocyst complex component 7

1

3

High-throughput

0.536

High

482933

CA216
UPF0500 protein C1orf216

1

2

High-throughput

0.523

High

482952

LRCH3
DISP complex protein LRCH3

1

0

High-throughput

0.513

High

482830

NEBU
Nebulin

1

2

Small-scale

0.501

High

482869

CDC42
Cell division control protein 42 homolog

1

14

High-throughput

0.501

High

482852

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.500

High

482862

STA5B
Signal transducer and activator of transcription 5B

1

3

High-throughput

0.500

High

482864

NKX25
Homeobox protein Nkx-2.5

1

5

High-throughput

0.500

High

482883

ELF3
ETS-related transcription factor Elf-3

1

2

High-throughput

0.500

High

482887

IRF8
Interferon regulatory factor 8

1

1

High-throughput

0.500

High

482841

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.493

High

482818

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

482833

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

3

High-throughput

0.489

High

482843

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.489

High

482858

NEST
Nestin

1

10

High-throughput

0.489

High

482866

GEM
GTP-binding protein GEM

1

6

High-throughput

0.489

High

482884

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

482888

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.489

High

482901

FL2D
Pre-mRNA-splicing regulator WTAP

1

2

High-throughput

0.489

High

482909

EAPP
E2F-associated phosphoprotein

1

1

High-throughput

0.489

High

482920

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

4

High-throughput

0.489

High

482921

COX15
Heme A synthase COX15

1

1

High-throughput

0.489

High

482943

ESR2
Estrogen receptor beta

1

13

Small-scale

0.489

High

69351

WASH1
WASH complex subunit 1

1

1

High-throughput

0.481

High

362641

EGFR
Epidermal growth factor receptor

1

3

Small-scale

0.481

High

482966

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

2

Small-scale

0.481

High

126443

RHOD
Rho-related GTP-binding protein RhoD

1

17

High-throughput

0.479

High

128731

MEN1
Menin

1

1

High-throughput

0.479

High

240552

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

245409

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

4

High-throughput

0.479

High

319325

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

323120

TRI37
E3 ubiquitin-protein ligase TRIM37

1

14

High-throughput

0.479

High

345283

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

352669

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

1

High-throughput

0.479

High

370521

FOS
Protein c-Fos

1

12

High-throughput

0.479

High

377927

TNFA
Tumor necrosis factor

1

9

High-throughput

0.479

High

387364

APOE
Apolipoprotein E

1

1

High-throughput

0.479

High

400162

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

413048

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

425270

ISG15
Ubiquitin-like protein ISG15

1

8

High-throughput

0.479

High

464769

SP1
Transcription factor Sp1

1

9

Small-scale

0.479

High

482821

ANDR
Androgen receptor

1

13

High-throughput

0.479

High

482823

ERG
Transcriptional regulator ERG

1

3

Small-scale

0.479

High

482824

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

2

High-throughput

0.479

High

482829

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

482832

FLNA
Filamin-A

1

6

High-throughput

0.479

High

482834

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.479

High

482835

MT3
Metallothionein-3

1

1

Small-scale

0.479

High

482839

CTNB1
Catenin beta-1

1

4

High-throughput

0.479

High

482849

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

482851

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

3

High-throughput

0.479

High

482854

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

482855

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

7

High-throughput

0.479

High

482856

CAZA2
F-actin-capping protein subunit alpha-2

1

5

High-throughput

0.479

High

482857

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.479

High

482859

CDK7
Cyclin-dependent kinase 7

1

7

High-throughput

0.479

High

482865

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

6

High-throughput

0.479

High

482872

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

482874

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.479

High

482882

H31
Histone H3.1

1

2

High-throughput

0.479

High

482885

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

Small-scale

0.479

High

482889

GOGA3
Golgin subfamily A member 3

1

14

High-throughput

0.479

High

482891

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

482892

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

482893

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

482894

TRI26
Tripartite motif-containing protein 26

1

4

Small-scale

0.479

High

482896

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

482902

TNIP1
TNFAIP3-interacting protein 1

1

18

High-throughput

0.479

High

482903

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

482906

DREB
Drebrin

1

2

High-throughput

0.479

High

482908

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

4

High-throughput

0.479

High

482910

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

Small-scale

0.479

High

482913

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

482916

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

482928

SYNPO
Synaptopodin

1

4

High-throughput

0.479

High

482939

ASB11
Ankyrin repeat and SOCS box protein 11

1

3

High-throughput

0.479

High

482941

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

482944

RYR2
Ryanodine receptor 2

1

4

High-throughput

0.479

High

482945

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

482948

CLUA1
Clusterin-associated protein 1

1

1

High-throughput

0.479

High

482949

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

482953

RHOV
Rho-related GTP-binding protein RhoV

1

18

High-throughput

0.479

High

482961

RHBT2
Rho-related BTB domain-containing protein 2

1

18

High-throughput

0.479

High

482965

ECT2
Protein ECT2

1

6

High-throughput

0.479

High

482968

PDLI7
PDZ and LIM domain protein 7

1

11

High-throughput

0.479

High

482972

SYLC
Leucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

482973

HDAC6
Protein deacetylase HDAC6

1

7

High-throughput

0.479

High

482974

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

482975

TES
Testin

1

13

High-throughput

0.479

High

482979

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

482984

AKT3
RAC-gamma serine/threonine-protein kinase

1

7

High-throughput

0.479

High

482985

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

1

High-throughput

0.479

High

482844

TGFR1
TGF-beta receptor type-1

1

0

Small-scale

0.458

High

482922

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

482959

MYOC
Myocilin

1

0

Small-scale

0.458

High

482963

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

249332

ZIC3
Zinc finger protein ZIC 3

1

4

High-throughput

0.457

High

482838

TLX1
T-cell leukemia homeobox protein 1

1

3

High-throughput

0.457

High

482840

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.445

High

482867

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

482877

GRB2
Growth factor receptor-bound protein 2

1

5

High-throughput

0.445

High

482878

1433Z
14-3-3 protein zeta/delta

1

10

High-throughput

0.445

High

482914

PKHA7
Pleckstrin homology domain-containing family A member 7

1

8

High-throughput

0.445

High

178153

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.437

High

352301

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

370989

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

405709

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.437

High

417901

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.437

High

482819

FURIN
Furin

1

3

High-throughput

0.437

High

482846

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.437

High

482850

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.437

High

482860

CDK9
Cyclin-dependent kinase 9

1

10

High-throughput

0.437

High

482886

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.437

High

482895

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.437

High

482900

MDC1
Mediator of DNA damage checkpoint protein 1

1

5

High-throughput

0.437

High

482904

SIX1
Homeobox protein SIX1

1

2

Small-scale

0.437

High

482905

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

482915

TET2
Methylcytosine dioxygenase TET2

1

2

Small-scale

0.437

High

482930

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

2

High-throughput

0.437

High

482937

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

482940

CLC4D
C-type lectin domain family 4 member D

1

4

High-throughput

0.437

High

482950

VMP1
Vacuole membrane protein 1

1

9

High-throughput

0.437

High

482955

PEO1
Twinkle mtDNA helicase

1

1

High-throughput

0.437

High

482956

KCD15
BTB/POZ domain-containing protein KCTD15

1

6

Small-scale

0.437

High

482962

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.437

High

482964

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

482970

RN181
E3 ubiquitin-protein ligase RNF181

1

4

High-throughput

0.437

High

482971

CFA97
Cilia- and flagella-associated protein 97

1

2

High-throughput

0.437

High

482831

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

254754

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.407

High

388833

APOH
Beta-2-glycoprotein 1

1

1

Small-scale

0.407

High

429177

JUN
Transcription factor Jun

1

13

High-throughput

0.407

High

482911

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.407

High

482929

CTL3
Choline transporter-like protein 3

1

1

High-throughput

0.407

High

482932

MFSD8
Major facilitator superfamily domain-containing protein 8

1

2

High-throughput

0.407

High

482958

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.407

High

482981

NAC2
Sodium/calcium exchanger 2

1

4

High-throughput

0.407

High

482934

CAGE1
Cancer-associated gene 1 protein

2

0

High-throughput

0.343

High

482847

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

2

0

Small-scale

0.322

High

482927

CLIP4
CAP-Gly domain-containing linker protein 4

1

0

High-throughput

0.282

High

482983

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

1

0

High-throughput

0.279

Low

482918

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

1

0

High-throughput

0.269

Low

482931

CC112
Coiled-coil domain-containing protein 112

1

0

High-throughput

0.269

Low

482899

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

482919

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025