Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF
Interactor 2: RNF31 (Q96EP0)
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
Gene: RNF31
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 0.60 | 0.764 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 30561431, 26670046, 27307491, 27545878, 30420664, 32019898, 31898971, 32968279, 33815386, 34610306, 35941131, 35688159, 37431163, 20005846, 23032187, 23032186, 23746843, 23732909, 24726327, 23955153 and 1 others
more... |
| Identification Methods | affinity chromatography technology, pull down, virotrap, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0051092 - positive regulation of NF-kappaB transcription factor activity |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Last updated: 11Aug2025
