HitPredict

Interactor 1: MYCN (P04198)
N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)
Gene: MYCN

Interactor 2: EP400 (Q96L91)
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
Gene: EP400

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29028833, 35013218
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 464 Hs			1 3159
+	Hs
		347609 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		229276 MYCN_HUMAN (1-464): 1.72e-89: 282: 100.00		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		229271 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		346003 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		SMCA1_HUMAN (938-1627): 0: 623: 19.83
+	Hs
		347406 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		CHD5_HUMAN (1501-2524): 1.9e-162: 558: 13.68
+	Hs
		346938 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		CHD9_HUMAN (1565-2538): 3.24e-144: 509: 13.41
+	Hs
		347951 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		CHD8_HUMAN (1521-2397): 1.55e-138: 490: 13.07
+	At
		1107221 MYC2_ARATH (16-463): 4.58e-39: 151: 14.22		BRM_ARATH (1848-2491): 4.41e-71: 269: 18.39
+	Hs
		379973 MYCN_HUMAN (1-464): 1.72e-89: 282: 100.00		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		379141 MYCN_HUMAN (1-464): 1.72e-89: 282: 100.00		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		379142 MYCN_HUMAN (1-464): 1.72e-89: 282: 100.00		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		347888 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		SMRCD_HUMAN (1895-2052): 1.85e-24: 115: 38.27
+	Hs
		347122 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Mm
		348440 MYC_MOUSE (5-463): 1.09e-71: 235: 33.95		EP400_MOUSE (2511-3159): 1.94e-10: 69.5: 10.79
+	Hs
		348113 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Mm
		348422 MYC_MOUSE (5-463): 1.09e-71: 235: 33.95		SMCA4_MOUSE (2528-2890): 6.78e-09: 64.1: 11.57
+	Hs
		346267 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		346268 MYC_HUMAN (7-463): 5.91e-69: 228: 34.16		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		738947 SRBP1_HUMAN (86-464): 8.15e-36: 143: 14.25		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		738948 SRBP1_HUMAN (86-464): 8.15e-36: 143: 14.25		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17