Protein: IGHM
Immunoglobulin heavy constant mu (Ig mu chain C region) (Ig mu chain C region BOT) (Ig mu chain C region GAL) (Ig mu chain C region OU)

Gene: IGHM
Organism: Homo sapiens
Interactions: 136
UniProt ID: P01871

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0002331 - pre-B cell allelic exclusion
GO:0003823 - antigen binding
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

210650

KLK10
Kallikrein-10

1

8

High-throughput

0.575

High

378750

KVD40
Immunoglobulin kappa variable 2D-40

1

16

High-throughput

0.575

High

378774

LV147
Immunoglobulin lambda variable 1-47

1

20

High-throughput

0.575

High

379059

IGKC
Immunoglobulin kappa constant

1

16

High-throughput

0.575

High

379482

FINC
Fibronectin

1

11

High-throughput

0.575

High

379551

FNDC5
Fibronectin type III domain-containing protein 5

1

5

High-throughput

0.575

High

379490

1433T
14-3-3 protein theta

2

8

High-throughput

0.552

High

132967

MATN2
Matrilin-2

1

9

High-throughput

0.514

High

379561

SNX27
Sorting nexin-27

2

11

High-throughput

0.504

High

379574

DDX31
ATP-dependent DNA helicase DDX31

2

8

High-throughput

0.504

High

379494

GSK3B
Glycogen synthase kinase-3 beta

1

6

High-throughput

0.457

High

379567

SH3G2
Endophilin-A1

1

7

High-throughput

0.457

High

48481

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.445

High

171384

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.445

High

194441

P2RX6
P2X purinoceptor 6

1

4

High-throughput

0.445

High

254718

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.445

High

316590

ST17B
Serine/threonine-protein kinase 17B

1

6

High-throughput

0.445

High

351633

SG1D1
Secretoglobin family 1D member 1

1

5

High-throughput

0.445

High

369797

CO3
Complement C3

1

1

High-throughput

0.445

High

379481

APOA1
Apolipoprotein A-I

1

3

High-throughput

0.445

High

379484

K2C1
Keratin, type II cytoskeletal 1

1

7

High-throughput

0.445

High

379485

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.445

High

379488

AATC
Aspartate aminotransferase, cytoplasmic

1

6

High-throughput

0.445

High

379491

CCR1
C-C chemokine receptor type 1

1

12

High-throughput

0.445

High

379492

K1C9
Keratin, type I cytoskeletal 9

1

12

High-throughput

0.445

High

379493

MTOR
Serine/threonine-protein kinase mTOR

1

4

High-throughput

0.445

High

379497

STX17
Syntaxin-17

1

3

High-throughput

0.445

High

379499

TBA4A
Tubulin alpha-4A chain

1

5

High-throughput

0.445

High

379500

HBB
Hemoglobin subunit beta

1

5

High-throughput

0.445

High

379504

TAP1
Antigen peptide transporter 1

1

1

High-throughput

0.445

High

379506

BTK
Tyrosine-protein kinase BTK

1

6

Small-scale

0.445

High

379507

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

379509

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

4

High-throughput

0.445

High

379512

PAPP1
Pappalysin-1

1

5

High-throughput

0.445

High

379513

ATM
Serine-protein kinase ATM

1

3

High-throughput

0.445

High

379514

TBB3
Tubulin beta-3 chain

1

5

High-throughput

0.445

High

379534

CSPG4
Chondroitin sulfate proteoglycan 4

1

6

High-throughput

0.445

High

379537

TBA1A
Tubulin alpha-1A chain

1

5

High-throughput

0.445

High

379548

ABD12
Lysophosphatidylserine lipase ABHD12

1

1

High-throughput

0.445

High

379552

AT11C
Phospholipid-transporting ATPase IG

1

2

High-throughput

0.445

High

379554

OR5H6
Olfactory receptor 5H6

1

2

High-throughput

0.445

High

379566

EGFL8
Epidermal growth factor-like protein 8

1

16

High-throughput

0.445

High

379572

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

6

High-throughput

0.445

High

379584

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

6

High-throughput

0.445

High

379586

TSN16
Tetraspanin-16

1

7

High-throughput

0.445

High

379588

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.445

High

164709

APOL1
Apolipoprotein L1

1

0

High-throughput

0.426

High

178598

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.426

High

249399

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.426

High

379486

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.426

High

379487

CD19
B-lymphocyte antigen CD19

1

0

Small-scale

0.426

High

379501

PRAME
Melanoma antigen preferentially expressed in tumors

1

0

High-throughput

0.426

High

379505

ATP7A
Copper-transporting ATPase 1

1

0

High-throughput

0.426

High

379557

SYMPK
Symplekin

1

0

High-throughput

0.426

High

379569

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

379570

ABHD6
Monoacylglycerol lipase ABHD6

1

0

High-throughput

0.426

High

379577

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.426

High

379590

DOP1B
Protein DOP1B

1

0

High-throughput

0.426

High

379483

KITH
Thymidine kinase, cytosolic

1

1

High-throughput

0.417

High

379519

MAPK3
MAP kinase-activated protein kinase 3

1

2

High-throughput

0.417

High

379579

UBQL4
Ubiquilin-4

1

8

High-throughput

0.417

High

379581

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

2

High-throughput

0.417

High

67415

GOG8A
Golgin subfamily A member 8A

1

6

High-throughput

0.407

High

166600

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

2

High-throughput

0.407

High

215770

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

1

High-throughput

0.407

High

228058

PM34
Peroxisomal membrane protein PMP34

1

6

High-throughput

0.407

High

325256

OR2A4
Olfactory receptor 2A4

1

6

High-throughput

0.407

High

335218

CXB5
Gap junction beta-5 protein

1

7

High-throughput

0.407

High

350338

ABHGA
Phosphatidylserine lipase ABHD16A

1

1

High-throughput

0.407

High

379496

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

4

High-throughput

0.407

High

379498

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

3

High-throughput

0.407

High

379502

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

7

High-throughput

0.407

High

379503

RUNX1
Runt-related transcription factor 1

1

3

High-throughput

0.407

High

379508

SRBP2
Sterol regulatory element-binding protein 2

1

3

High-throughput

0.407

High

379510

STK4
Serine/threonine-protein kinase 4

1

10

High-throughput

0.407

High

379511

STK3
Serine/threonine-protein kinase 3

1

8

High-throughput

0.407

High

379516

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.407

High

379517

UBE3C
Ubiquitin-protein ligase E3C

1

4

High-throughput

0.407

High

379522

T176B
Transmembrane protein 176B

1

3

High-throughput

0.407

High

379525

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

1

High-throughput

0.407

High

379526

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

9

High-throughput

0.407

High

379528

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

9

High-throughput

0.407

High

379530

ACD10
Acyl-CoA dehydrogenase family member 10

1

1

High-throughput

0.407

High

379531

SFXN4
Sideroflexin-4

1

5

High-throughput

0.407

High

379533

CTR9
RNA polymerase-associated protein CTR9 homolog

1

4

High-throughput

0.407

High

379535

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

3

High-throughput

0.407

High

379538

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.407

High

379542

CIR1
Corepressor interacting with RBPJ 1

1

6

High-throughput

0.407

High

379543

MICU3
Calcium uptake protein 3, mitochondrial

1

2

High-throughput

0.407

High

379544

CERS3
Ceramide synthase 3

1

6

High-throughput

0.407

High

379545

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.407

High

379546

ELOA2
Elongin-A2

1

5

High-throughput

0.407

High

379549

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

1

High-throughput

0.407

High

379555

RHBL4
Rhomboid-related protein 4

1

7

High-throughput

0.407

High

379556

GCN1
Stalled ribosome sensor GCN1

1

1

High-throughput

0.407

High

379559

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.407

High

379563

CP2S1
Cytochrome P450 2S1

1

3

High-throughput

0.407

High

379564

ARI3A
AT-rich interactive domain-containing protein 3A

1

1

Small-scale

0.407

High

379565

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

10

High-throughput

0.407

High

379568

TBA1C
Tubulin alpha-1C chain

1

5

High-throughput

0.407

High

379573

SAV1
Protein salvador homolog 1

1

5

High-throughput

0.407

High

379575

WDR76
WD repeat-containing protein 76

1

3

High-throughput

0.407

High

379576

COE2
Transcription factor COE2

1

5

High-throughput

0.407

High

379578

MBNL1
Muscleblind-like protein 1

1

3

High-throughput

0.407

High

379580

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1

9

High-throughput

0.407

High

379582

BAZ1B
Tyrosine-protein kinase BAZ1B

1

3

High-throughput

0.407

High

379583

PHF11
PHD finger protein 11

1

10

High-throughput

0.407

High

379585

FBX2
F-box only protein 2

1

4

High-throughput

0.407

High

379587

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

2

High-throughput

0.407

High

379540

PATL1
Protein PAT1 homolog 1

2

0

High-throughput

0.288

High

379489

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.238

Low

379518

SMN
Survival motor neuron protein

1

0

High-throughput

0.238

Low

379558

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.238

Low

187434

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.232

Low

261685

HUS1
Checkpoint protein HUS1

1

0

High-throughput

0.232

Low

317769

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.232

Low

379495

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

0

High-throughput

0.232

Low

379515

STAR3
StAR-related lipid transfer protein 3

1

0

High-throughput

0.232

Low

379520

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.232

Low

379521

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

0

High-throughput

0.232

Low

379523

SPDE7
Putative speedy protein E7

1

0

High-throughput

0.232

Low

379524

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.232

Low

379527

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.232

Low

379529

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.232

Low

379532

GOLM2
Protein GOLM2

1

0

High-throughput

0.232

Low

379536

ZN574
Zinc finger protein 574

1

0

High-throughput

0.232

Low

379539

VP13B
Intermembrane lipid transfer protein VPS13B

1

0

High-throughput

0.232

Low

379541

ADCK1
AarF domain-containing protein kinase 1

1

0

High-throughput

0.232

Low

379547

GHDC
GH3 domain-containing protein

1

0

High-throughput

0.232

Low

379550

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

0

High-throughput

0.232

Low

379553

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.232

Low

379560

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.232

Low

379562

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

0

High-throughput

0.232

Low

379571

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.232

Low

379589

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.232

Low

379591

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025