Protein: RUNX2
Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)

Gene: RUNX2
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q13950

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001503 - ossification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1119467

PEBB
Core-binding factor subunit beta

5

8

Small-scale

0.922

High

862118

YAP1
Transcriptional coactivator YAP1

5

19

Small-scale

0.704

High

1029828

RUNX1
Runt-related transcription factor 1

1

2

High-throughput

0.691

High

1117046

RUNX3
Runt-related transcription factor 3

1

2

High-throughput

0.691

High

1067308

EP300
Histone acetyltransferase p300

4

9

Small-scale

0.676

High

1014507

SMAD3
Mothers against decapentaplegic homolog 3

3

16

Small-scale

0.664

High

370665

FOS
Protein c-Fos

2

3

Small-scale

0.651

High

429865

JUN
Transcription factor Jun

2

3

Small-scale

0.651

High

604655

UBF1
Nucleolar transcription factor 1

3

9

Small-scale

0.646

High

940959

HDAC4
Histone deacetylase 4

3

16

Small-scale

0.640

High

1109708

HDAC1
Histone deacetylase 1

3

11

Small-scale

0.640

High

1119472

SMAD1
Mothers against decapentaplegic homolog 1

3

16

Small-scale

0.640

High

188272

HDAC3
Histone deacetylase 3

2

9

Small-scale

0.624

High

1119496

CHIP
E3 ubiquitin-protein ligase CHIP

2

1

Small-scale

0.614

High

873085

SOX9
Transcription factor SOX-9

2

9

Small-scale

0.602

High

442706

RB
Retinoblastoma-associated protein

2

2

Small-scale

0.595

High

1109258

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.589

High

609674

LEG3
Galectin-3

2

1

Small-scale

0.584

High

1119489

SMAD5
Mothers against decapentaplegic homolog 5

2

16

Small-scale

0.584

High

1119494

HDAC6
Protein deacetylase HDAC6

2

16

Small-scale

0.584

High

1119498

HDAC5
Histone deacetylase 5

2

16

Small-scale

0.584

High

1119484

KAT6B
Histone acetyltransferase KAT6B

1

4

Small-scale

0.578

High

371987

MYC
Myc proto-oncogene protein

2

3

Small-scale

0.571

High

1119469

HES1
Transcription factor HES-1

2

0

Small-scale

0.569

High

1119468

FHL2
Four and a half LIM domains protein 2

1

1

Small-scale

0.561

High

1119473

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

Small-scale

0.561

High

1119478

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

2

Small-scale

0.561

High

1119483

HDAC7
Histone deacetylase 7

1

16

Small-scale

0.561

High

1119487

RBM14
RNA-binding protein 14

1

3

Small-scale

0.561

High

1119474

ZEP3
Transcription factor HIVEP3

1

0

Small-scale

0.537

High

1119497

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

0

Small-scale

0.537

High

347694

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.536

High

1047814

TLE1
Transducin-like enhancer protein 1

1

10

Small-scale

0.536

High

1088243

TCF15
Transcription factor 15

1

7

High-throughput

0.536

High

1119476

FBW12
F-box/WD repeat-containing protein 12

1

2

High-throughput

0.536

High

186206

PPM1D
Protein phosphatase 1D

1

0

Small-scale

0.530

High

532579

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.513

High

635315

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.513

High

1119495

FEM1B
Protein fem-1 homolog B

1

0

High-throughput

0.513

High

577436

ETS1
Protein C-ets-1

1

4

Small-scale

0.501

High

1119479

THOC4
THO complex subunit 4

1

2

Small-scale

0.501

High

1119491

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

11

Small-scale

0.501

High

85982

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

2

High-throughput

0.489

High

547445

DMD
Dystrophin

1

0

High-throughput

0.480

High

132026

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

11

Small-scale

0.479

High

186753

P73
Tumor protein p73

1

2

Small-scale

0.479

High

216434

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

Small-scale

0.479

High

219864

SMAD6
Mothers against decapentaplegic homolog 6

1

16

Small-scale

0.479

High

413805

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

558120

XRCC6
X-ray repair cross-complementing protein 6

1

2

Small-scale

0.479

High

559349

XRCC5
X-ray repair cross-complementing protein 5

1

2

Small-scale

0.479

High

714106

PML
Protein PML

1

6

Small-scale

0.479

High

764740

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

772159

MSX2
Homeobox protein MSX-2

1

2

Small-scale

0.479

High

827775

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.479

High

838361

STA5A
Signal transducer and activator of transcription 5A

1

1

Small-scale

0.479

High

872312

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.479

High

886840

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

941435

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.479

High

984108

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

1101810

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

1114803

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1115184

CUL4B
Cullin-4B

1

1

High-throughput

0.479

High

1119470

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

3

Small-scale

0.479

High

1119471

SMAD2
Mothers against decapentaplegic homolog 2

1

16

Small-scale

0.479

High

1119485

CBP
CREB-binding protein

1

8

Small-scale

0.479

High

1119486

KAT2B
Histone acetyltransferase KAT2B

1

5

Small-scale

0.479

High

1119488

CIC
Protein capicua homolog

1

7

High-throughput

0.479

High

1119490

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

11

Small-scale

0.479

High

1119492

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

11

Small-scale

0.479

High

1119499

NCOA3
Nuclear receptor coactivator 3

1

5

Small-scale

0.479

High

787161

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

Small-scale

0.458

High

1119475

PMF1
Polyamine-modulated factor 1

1

0

Small-scale

0.458

High

1119477

DET1
DET1 homolog

1

0

High-throughput

0.458

High

440550

FYN
Tyrosine-protein kinase Fyn

1

4

High-throughput

0.445

High

1119480

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

1119493

WRP73
WD repeat-containing protein WRAP73

1

1

High-throughput

0.445

High

1119481

KCD17
BTB/POZ domain-containing protein KCTD17

1

0

High-throughput

0.426

High

1119482

POC5
Centrosomal protein POC5

1

0

Small-scale

0.426

High

379642

IGHA1
Immunoglobulin heavy constant alpha 1

1

2

High-throughput

0.407

High

379738

IGHA2
Immunoglobulin heavy constant alpha 2

1

3

High-throughput

0.407

High

378684

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025