HitPredict

Interactor 1: S100B (P04271)
Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)
Gene: S100B

Interactor 2: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	21693575, 17726019, 17660747
Identification Methods	affinity chromatography technology, surface plasmon resonance, enzyme linked immunosorbent assay, filter binding
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	C2-set_2~S_100, Ig_3~S_100
Common GO terms	GO:0005576 - extracellular region GO:0007611 - learning or memory GO:0044548 - S100 protein binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 92 Hs			1 404
+	Rn
		385826 S100B_RAT (1-92): 3.96e-31: 106: 97.83		RAGE_RAT (1-404): 1.03e-73: 237: 77.97
+	Hs
		638960 S100P_HUMAN (1-91): 2.35e-34: 114: 50.55		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		615216 S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		642944 S10A4_HUMAN (3-90): 2.3e-30: 104: 47.73		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		946195 S10AC_HUMAN (1-92): 2.11e-29: 102: 38.04		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		793247 S10AA_HUMAN (2-89): 2.16e-29: 102: 38.64		MUC18_HUMAN (22-301): 1.39e-58: 203: 24.92
+	Hs
		639033 S100P_HUMAN (1-91): 2.35e-34: 114: 50.55		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42
+	Hs
		642975 S10A4_HUMAN (3-90): 2.3e-30: 104: 47.73		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42
+	Hs
		661374 S10A2_HUMAN (2-90): 1.34e-29: 102: 44.94		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42