Protein: HDAC9
Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)

Gene: HDAC9
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q9UKV0

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001818 - negative regulation of cytokine production
GO:0003714 - transcription corepressor activity
GO:0004407 - histone deacetylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110175

HDAC1
Histone deacetylase 1

3

17

Small-scale

0.857

High

188388

HDAC3
Histone deacetylase 3

2

17

Small-scale

0.785

High

1403049

SIN3A
Paired amphipathic helix protein Sin3a

2

19

Small-scale

0.768

High

1461241

HDAC9
Histone deacetylase 9

2

17

Small-scale

0.754

High

278450

NCOR1
Nuclear receptor corepressor 1

1

20

Small-scale

0.747

High

941087

HDAC4
Histone deacetylase 4

1

18

Small-scale

0.681

High

1458536

HDAC6
Protein deacetylase HDAC6

1

19

Small-scale

0.665

High

274399

SIN3B
Paired amphipathic helix protein Sin3b

1

19

Small-scale

0.647

High

1258974

H32
Histone H3.2

1

20

Small-scale

0.647

High

1022595

PKD1
Polycystin-1

2

4

Small-scale

0.646

High

1055036

MEF2C
Myocyte-specific enhancer factor 2C

2

20

High-throughput

0.632

High

832831

BCL6
B-cell lymphoma 6 protein

2

9

Small-scale

0.621

High

1017289

H33
Histone H3.3

1

20

Small-scale

0.618

High

972117

1433E
14-3-3 protein epsilon

2

12

Small-scale

0.614

High

1437025

ANRA2
Ankyrin repeat family A protein 2

2

19

Small-scale

0.602

High

1034705

MEF2A
Myocyte-specific enhancer factor 2A

2

20

Small-scale

0.595

High

1103437

CTBP1
C-terminal-binding protein 1

2

12

Small-scale

0.595

High

158516

RFXK
DNA-binding protein RFXANK

1

20

Small-scale

0.561

High

849270

KSYK
Tyrosine-protein kinase SYK

1

18

Small-scale

0.561

High

853752

MK08
Mitogen-activated protein kinase 8

1

12

Small-scale

0.561

High

853866

MK09
Mitogen-activated protein kinase 9

1

13

Small-scale

0.561

High

923400

MK10
Mitogen-activated protein kinase 10

1

13

Small-scale

0.561

High

1120987

TRI29
Tripartite motif-containing protein 29

1

9

Small-scale

0.561

High

1365157

MAML1
Mastermind-like protein 1

1

16

Small-scale

0.561

High

874013

NRIP1
Nuclear receptor-interacting protein 1

1

4

High-throughput

0.541

High

390213

ALBU
Albumin

1

4

High-throughput

0.536

High

457932

INVO
Involucrin

1

8

High-throughput

0.536

High

542274

TOP1
DNA topoisomerase 1

1

4

High-throughput

0.536

High

552891

TPR
Nucleoprotein TPR

1

20

High-throughput

0.536

High

568988

ANXA8
Annexin A8

1

5

High-throughput

0.536

High

570631

GFAP
Glial fibrillary acidic protein

1

12

High-throughput

0.536

High

616376

RCC1
Regulator of chromosome condensation

1

6

High-throughput

0.536

High

787722

SPB5
Serpin B5

1

4

High-throughput

0.536

High

818775

CAPG
Macrophage-capping protein

1

4

High-throughput

0.536

High

854381

KI67
Proliferation marker protein Ki-67

1

6

High-throughput

0.536

High

855252

NOP2
28S rRNA

1

7

High-throughput

0.536

High

937368

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

11

High-throughput

0.536

High

941299

IF6
Eukaryotic translation initiation factor 6

1

2

High-throughput

0.536

High

999426

HBB
Hemoglobin subunit beta

1

4

High-throughput

0.536

High

1323184

CCAR2
Cell cycle and apoptosis regulator protein 2

1

5

High-throughput

0.536

High

1363648

H1X
Histone H1.10

1

1

High-throughput

0.536

High

1399786

RBM14
RNA-binding protein 14

1

13

High-throughput

0.536

High

1461242

TPX2
Targeting protein for Xklp2

1

1

High-throughput

0.536

High

1461243

SMC3
Structural maintenance of chromosomes protein 3

1

12

High-throughput

0.536

High

833036

ETV6
Transcription factor ETV6

1

11

Small-scale

0.534

High

1420208

FOXP3
Forkhead box protein P3

1

20

Small-scale

0.534

High

273017

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

1248095

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.513

High

397188

ESR1
Estrogen receptor

1

20

Small-scale

0.501

High

430493

JUN
Transcription factor Jun

1

20

Small-scale

0.501

High

980523

H4
Histone H4

1

13

Small-scale

0.501

High

1323482

NUP93
Nuclear pore complex protein Nup93

1

1

High-throughput

0.489

High

648386

USF1
Upstream stimulatory factor 1

1

20

Small-scale

0.484

High

990854

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.481

High

414818

P53
Cellular tumor antigen p53

1

9

Small-scale

0.479

High

487869

PARP1
Poly [ADP-ribose] polymerase 1

1

18

Small-scale

0.479

High

607210

CEBPB
CCAAT/enhancer-binding protein beta

1

20

Small-scale

0.479

High

613222

EGR1
Early growth response protein 1

1

5

High-throughput

0.479

High

730950

1433S
14-3-3 protein sigma

1

20

Small-scale

0.479

High

775615

NU214
Nuclear pore complex protein Nup214

1

20

Small-scale

0.479

High

789592

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

837897

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

4

High-throughput

0.479

High

890229

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

1

Small-scale

0.479

High

903515

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.479

High

1120044

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

11

Small-scale

0.479

High

1136880

MO4L2
Mortality factor 4-like protein 2

1

7

Small-scale

0.479

High

1429010

WWTR1
WW domain-containing transcription regulator protein 1

1

11

Small-scale

0.479

High

1458600

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

7

Small-scale

0.479

High

1433323

WNK1
Serine/threonine-protein kinase WNK1

1

12

High-throughput

0.457

High

1034718

MEF2B
Myocyte-specific enhancer factor 2B

1

20

Small-scale

0.445

High

322343

GLSK
Glutaminase kidney isoform, mitochondrial

1

6

Small-scale

0.437

High

1335773

MOT11
Monocarboxylate transporter 11

1

5

High-throughput

0.407

High

86051

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

0

High-throughput

0.279

Low

369411

A1AT
Alpha-1-antitrypsin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025