Protein: HBB
Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]

Gene: HBB
Organism: Homo sapiens
Interactions: 189
UniProt ID: P68871

Gene Ontology (top 5):
GO:0005344 - oxygen carrier activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol
GO:0005833 - hemoglobin complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

999337

HBA
Hemoglobin subunit alpha

15

18

Small-scale

0.984

High

380699

HBAZ
Hemoglobin subunit zeta

5

16

Small-scale

0.912

High

479183

HBAT
Hemoglobin subunit theta-1

2

17

High-throughput

0.783

High

999368

HBM
Hemoglobin subunit mu

2

18

High-throughput

0.783

High

366167

HPT
Haptoglobin

2

2

Small-scale

0.754

High

210740

KLK10
Kallikrein-10

1

3

High-throughput

0.691

High

380813

HBE
Hemoglobin subunit epsilon

1

19

High-throughput

0.691

High

469785

CATG
Cathepsin G

1

1

High-throughput

0.691

High

635656

ASPG
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

3

1

High-throughput

0.667

High

999384

GDPD1
Lysophospholipase D GDPD1

3

2

High-throughput

0.667

High

999420

PGPI
Pyroglutamyl-peptidase 1

3

1

High-throughput

0.667

High

255521

CYTIP
Cytohesin-interacting protein

3

0

High-throughput

0.638

High

999387

JOS2
Josephin-2

3

0

High-throughput

0.638

High

999428

CSN3
COP9 signalosome complex subunit 3

3

0

High-throughput

0.638

High

999429

MGT4B
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

3

0

High-throughput

0.634

High

999424

DACH1
Dachshund homolog 1

3

0

High-throughput

0.629

High

208124

PLXB1
Plexin-B1

2

2

High-throughput

0.628

High

449703

H2B1J
Histone H2B type 1-J

2

1

High-throughput

0.628

High

536946

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.628

High

721472

GSTT1
Glutathione S-transferase theta-1

2

1

High-throughput

0.628

High

999359

MK06
Mitogen-activated protein kinase 6

2

3

High-throughput

0.628

High

999408

REN3A
Regulator of nonsense transcripts 3A

2

2

High-throughput

0.628

High

999434

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.618

High

999364

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

3

1

High-throughput

0.609

High

643184

BMP5
Bone morphogenetic protein 5

2

0

High-throughput

0.602

High

968874

PRS8
26S proteasome regulatory subunit 8

2

0

High-throughput

0.602

High

999341

SEMG2
Semenogelin-2

2

0

High-throughput

0.602

High

690895

1433T
14-3-3 protein theta

2

4

High-throughput

0.601

High

999427

GRID1
Glutamate receptor ionotropic, delta-1

2

0

High-throughput

0.585

High

999345

FOXO1
Forkhead box protein O1

2

3

High-throughput

0.584

High

999389

GTR14
Solute carrier family 2, facilitated glucose transporter member 14

2

1

High-throughput

0.574

High

999399

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

1

High-throughput

0.574

High

999411

MSL2
E3 ubiquitin-protein ligase MSL2

2

1

High-throughput

0.574

High

999353

ARHG6
Rho guanine nucleotide exchange factor 6

2

2

High-throughput

0.571

High

999346

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

2

1

High-throughput

0.549

High

999369

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

2

High-throughput

0.549

High

85971

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

4

High-throughput

0.536

High

133016

MATN2
Matrilin-2

1

2

High-throughput

0.536

High

140224

SDCB1
Syntenin-1

1

2

High-throughput

0.536

High

155395

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

1

High-throughput

0.536

High

301800

ANXA9
Annexin A9

1

1

High-throughput

0.536

High

351678

SG1D1
Secretoglobin family 1D member 1

1

2

High-throughput

0.536

High

479206

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

2

High-throughput

0.536

High

727761

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.536

High

732806

GLPK
Glycerol kinase

1

1

High-throughput

0.536

High

985433

RL32
Large ribosomal subunit protein eL32

1

2

High-throughput

0.536

High

999347

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

1

High-throughput

0.536

High

999363

FBLN7
Fibulin-7

1

1

High-throughput

0.536

High

999370

ARMD1
Armadillo-like helical domain containing protein 1

1

1

High-throughput

0.536

High

999372

PXK
PX domain-containing protein kinase-like protein

1

3

High-throughput

0.536

High

999388

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

1

High-throughput

0.536

High

999394

KIFA3
Kinesin-associated protein 3

1

1

High-throughput

0.536

High

999407

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.536

High

999422

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.536

High

999426

HDAC9
Histone deacetylase 9

1

4

High-throughput

0.536

High

975544

SELT
Thioredoxin reductase-like selenoprotein T

1

0

High-throughput

0.518

High

577389

OXDA
D-amino-acid oxidase

1

0

High-throughput

0.513

High

609650

LEG3
Galectin-3

1

0

High-throughput

0.513

High

692189

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.513

High

870185

GLIP1
Glioma pathogenesis-related protein 1

1

0

High-throughput

0.513

High

943033

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

961942

RHOA
Transforming protein RhoA

1

0

High-throughput

0.513

High

999340

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

High-throughput

0.513

High

999361

FNDC1
Fibronectin type III domain-containing protein 1

1

0

High-throughput

0.513

High

999386

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

1

0

High-throughput

0.513

High

999391

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

999412

PDE7B
3',5'-cyclic-AMP phosphodiesterase 7B

1

0

High-throughput

0.513

High

999437

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

999355

ETFD
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.493

High

184155

RER1
Protein RER1

1

1

High-throughput

0.489

High

194463

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.489

High

355490

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

High-throughput

0.489

High

451364

NFM
Neurofilament medium polypeptide

1

4

High-throughput

0.489

High

851053

LPAR6
Lysophosphatidic acid receptor 6

1

1

High-throughput

0.489

High

853983

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.489

High

999344

DMWD
Dystrophia myotonica WD repeat-containing protein

1

1

High-throughput

0.489

High

999358

TAF12
Transcription initiation factor TFIID subunit 12

1

1

High-throughput

0.489

High

999360

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

2

High-throughput

0.489

High

999366

C1QL3
Complement C1q-like protein 3

1

1

High-throughput

0.489

High

999375

CACL1
CDK2-associated and cullin domain-containing protein 1

1

2

High-throughput

0.489

High

999381

DTWD1
tRNA-uridine aminocarboxypropyltransferase 1

1

1

High-throughput

0.489

High

999390

ZDH19
Palmitoyltransferase ZDHHC19

1

2

High-throughput

0.489

High

999397

CI085
Uncharacterized protein C9orf85

1

1

High-throughput

0.489

High

999400

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.489

High

999413

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.489

High

999414

RIC8A
Chaperone Ric-8A

1

1

High-throughput

0.489

High

999430

T3JAM
TRAF3-interacting JNK-activating modulator

1

3

High-throughput

0.489

High

999431

CDYL
Chromodomain Y-like protein

1

1

High-throughput

0.489

High

999433

PLLP
Plasmolipin

1

1

High-throughput

0.489

High

170077

AURKA
Aurora kinase A

1

2

High-throughput

0.479

High

302475

RNF8
E3 ubiquitin-protein ligase RNF8

1

3

High-throughput

0.479

High

345654

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

369338

A1AT
Alpha-1-antitrypsin

1

1

High-throughput

0.479

High

369451

AACT
Alpha-1-antichymotrypsin

1

1

High-throughput

0.479

High

387258

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.479

High

390285

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.479

High

390882

TRFE
Serotransferrin

1

2

High-throughput

0.479

High

391136

HEMO
Hemopexin

1

1

High-throughput

0.479

High

395876

ESR1
Estrogen receptor

1

5

High-throughput

0.479

High

403971

GCR
Glucocorticoid receptor

1

5

Small-scale

0.479

High

563607

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

623269

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

641560

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

8

High-throughput

0.479

High

723913

LCN1
Lipocalin-1

1

1

High-throughput

0.479

High

728163

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.479

High

887961

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

951604

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

970307

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

986329

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

999352

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

999356

PROL4
Proline-rich protein 4

1

1

High-throughput

0.479

High

999362

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

999373

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

999374

ARHGP
Rho guanine nucleotide exchange factor 25

1

2

High-throughput

0.479

High

999393

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

999401

CP250
Centrosome-associated protein CEP250

1

3

High-throughput

0.479

High

999402

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

999423

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

999435

TRAF6
TNF receptor-associated factor 6

1

6

Small-scale

0.479

High

353238

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

361533

CERU
Ceruloplasmin

1

0

High-throughput

0.458

High

389655

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.458

High

391732

STAT
Statherin

1

0

High-throughput

0.458

High

413599

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

667761

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

702926

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

957318

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

999380

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.458

High

999404

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

999410

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.458

High

999415

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

999416

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.458

High

379500

IGHM
Immunoglobulin heavy constant mu

1

5

High-throughput

0.445

High

529601

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

622147

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.445

High

942548

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

999348

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

2

High-throughput

0.445

High

105735

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

277286

PITX3
Pituitary homeobox 3

1

2

Small-scale

0.437

High

293542

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

878945

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

999354

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

999376

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.437

High

999377

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.437

High

999379

RHG24
Rho GTPase-activating protein 24

1

5

High-throughput

0.437

High

999392

ESR2
Estrogen receptor beta

1

5

High-throughput

0.437

High

999406

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

999421

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

906866

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.426

High

938699

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

0

High-throughput

0.426

High

999395

ARL8A
ADP-ribosylation factor-like protein 8A

1

0

High-throughput

0.426

High

999396

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.426

High

999403

FGFP2
Fibroblast growth factor-binding protein 2

1

0

High-throughput

0.426

High

329832

SNX4
Sorting nexin-4

1

1

High-throughput

0.407

High

337716

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.407

High

346628

TTC4
Tetratricopeptide repeat protein 4

1

1

High-throughput

0.407

High

607917

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

1

High-throughput

0.407

High

999343

GOGA2
Golgin subfamily A member 2

1

6

High-throughput

0.407

High

999350

GLPK3
Glycerol kinase 3

1

1

High-throughput

0.407

High

999405

CD244
Natural killer cell receptor 2B4

1

2

High-throughput

0.407

High

999371

TMM92
Transmembrane protein 92

3

0

High-throughput

0.347

High

60712

F234B
Protein FAM234B

2

0

High-throughput

0.328

High

179707

MDM4
Protein Mdm4

2

0

High-throughput

0.328

High

999409

LPAR2
Lysophosphatidic acid receptor 2

2

0

High-throughput

0.328

High

999383

PLPL1
Omega-hydroxyceramide transacylase

2

0

High-throughput

0.318

High

252517

SEP15
Selenoprotein F

1

0

High-throughput

0.279

Low

254956

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

662315

PAX3
Paired box protein Pax-3

1

0

High-throughput

0.279

Low

999339

BNC1
Zinc finger protein basonuclin-1

1

0

High-throughput

0.279

Low

999342

HEN2
Helix-loop-helix protein 2

1

0

High-throughput

0.279

Low

999351

SL9A5
Sodium/hydrogen exchanger 5

1

0

High-throughput

0.279

Low

999365

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

0

High-throughput

0.279

Low

999367

MSL1
Male-specific lethal 1 homolog

1

0

High-throughput

0.279

Low

999378

APCD1
Protein APCDD1

1

0

High-throughput

0.279

Low

999382

FRMD1
FERM domain-containing protein 1

1

0

High-throughput

0.279

Low

999385

C2C4A
C2 calcium-dependent domain-containing protein 4A

1

0

High-throughput

0.279

Low

999418

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.279

Low

999425

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.279

Low

999357

SSX2
Protein SSX2

1

0

High-throughput

0.269

Low

276104

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.249

Low

674132

BRD2
Bromodomain-containing protein 2

1

0

High-throughput

0.249

Low

999338

EREP3
Protein ENTREP3

1

0

High-throughput

0.249

Low

999417

BMP2K
BMP-2-inducible protein kinase

1

0

Small-scale

0.238

Low

191956

TEX28
Testis-specific protein TEX28

1

0

High-throughput

0.232

Low

999349

VGLL4
Transcription cofactor vestigial-like protein 4

1

0

High-throughput

0.232

Low

999398

OPALI
Opalin

1

0

High-throughput

0.232

Low

999419

ADPRS
ADP-ribosylhydrolase ARH3

1

0

High-throughput

0.232

Low

999432

OFUT2
GDP-fucose protein O-fucosyltransferase 2

1

0

High-throughput

0.232

Low

999436

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025