HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: MUC4 (Q99102)
Mucin-4 (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Testis mucin) (Tracheobronchial mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1) (ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2) (ASGP-2)]
Gene: MUC4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	25315821, 18381409
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 5412
+	Hs
		1071005 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		MUC4_HUMAN (1-5412): 0: 1942: 100.00
+	Hs
		338878 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MUC4_HUMAN (1-5412): 0: 1942: 100.00
+	Hs
		601984 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		MUC4_HUMAN (1-5412): 0: 1942: 100.00
+	Hs
		383583 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MUC1_HUMAN (3322-4360): 1.58e-58: 227: 13.62
+	Hs
		554307 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		MUC1_HUMAN (3322-4360): 1.58e-58: 227: 13.62
+	Hs
		337875 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MUC1_HUMAN (3322-4360): 1.58e-58: 227: 13.62
+	Hs
		554266 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		MUC1_HUMAN (3322-4360): 1.58e-58: 227: 13.62
+	Hs
		338765 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MUC16_HUMAN (11-2750): 1.82e-48: 196: 11.09
+	Hs
		339147 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SRRM2_HUMAN (11-2594): 2.16e-43: 179: 11.08
+	Hs
		338965 EGFR_HUMAN (16-1253): 0: 1070: 48.40		TARA_HUMAN (3377-4389): 1.07e-16: 91.1: 10.06
+	Hs
		338621 EGFR_HUMAN (16-1253): 0: 1070: 48.40		GRIN1_HUMAN (1067-1840): 2.07e-13: 79.5: 15.44
+	Hs
		338769 EGFR_HUMAN (16-1253): 0: 1070: 48.40		TITIN_HUMAN (1-739): 1.66e-11: 74.1: 10.55
+	Hs
		338874 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MINT_HUMAN (6-949): 4.8e-11: 72.2: 7.95
+	Hs
		238439 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		MUC5B_HUMAN (3-2433): 1.57e-31: 140: 14.44
+	Hs
		311786 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		TACC2_HUMAN (2415-4422): 7.47e-28: 127: 9.08
+	Hs
		434228 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		GRIN1_HUMAN (1067-1840): 2.07e-13: 79.5: 15.44
+	Mm
		975153 EPHA4_MOUSE (668-1030): 1.51e-121: 403: 31.45		NCOR2_MOUSE (9-1713): 6.46e-15: 84.9: 8.79
+	Hs
		665620 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		GRIN1_HUMAN (1067-1840): 2.07e-13: 79.5: 15.44
+	Hs
		983695 FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07		SRRM2_HUMAN (11-2594): 2.16e-43: 179: 11.08
+	Hs
		616857 JAK1_HUMAN (674-1035): 3.11e-43: 174: 21.47		CIC_HUMAN (10-1426): 8.72e-10: 68.2: 10.48