HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: GBB2 (P62879)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2)
Gene: GNB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	24189400
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 340
+	Hs
		383985 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00
+	Hs
		383588 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GBB3_HUMAN (1-340): 2.27e-106: 316: 80.88
+	Hs
		383727 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GBB1_HUMAN (1-340): 1.35e-106: 316: 90.29
+	Hs
		338250 EGFR_HUMAN (16-1253): 0: 1070: 48.40		GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00
+	Hs
		383677 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LIS1_HUMAN (258-340): 1.53e-19: 90.5: 22.89
+	Hs
		920973 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		GBB1_HUMAN (1-340): 1.35e-106: 316: 90.29
+	Hs
		665199 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00
+	Hs
		872421 EPHA5_HUMAN (707-1010): 2.37e-53: 206: 37.46		GBB1_HUMAN (1-340): 1.35e-106: 316: 90.29
+	Hs
		920944 FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07		GBB1_HUMAN (1-340): 1.35e-106: 316: 90.29
+	Rn
		192655 INSR_RAT (357-634): 2.53e-16: 87.2: 19.87		GBB4_RAT (1-340): 8.85e-104: 309: 89.71