HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0008285 - negative regulation of cell population proliferation GO:0042803 - protein homodimerization activity GO:0045766 - positive regulation of angiogenesis GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 770
+	Hs
		507894 FGFR1_HUMAN (195-794): 0: 545: 26.34		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		384428 NTRK1_HUMAN (1-796): 0: 621: 100.00		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		601474 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		609197 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		434150 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776626 EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		384522 NTRK1_HUMAN (1-796): 0: 621: 100.00		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		776653 ROR1_HUMAN (515-783): 1.16e-72: 257: 46.89		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		435568 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		411328 INSR_HUMAN (493-777): 3e-68: 248: 42.62		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776663 DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776856 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		601481 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		601477 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Rn
		94369 INSR_RAT (493-777): 7.31e-66: 241: 41.95		F1M9D6_RAT (1-749): 0: 935: 51.71
+	Hs
		786329 DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		411341 INSR_HUMAN (493-777): 3e-68: 248: 42.62		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		849885 DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		411330 INSR_HUMAN (493-777): 3e-68: 248: 42.62		STA5A_HUMAN (1-734): 0: 745: 30.42