Protein: PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-gamma-2) (PLC-gamma-2)

Gene: PLCG2
Organism: Mus musculus
Interactions: 41
UniProt ID: Q8CIH5

Gene Ontology (top 5):
GO:0001775 - cell activation
GO:0001784 - phosphotyrosine residue binding
GO:0001878 - response to yeast
GO:0002092 - positive regulation of receptor internalization
GO:0002223 - stimulatory C-type lectin receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

483867

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

20

Small-scale

0.680

High

575636

EPOR
Erythropoietin receptor

1

7

Small-scale

0.665

High

683108

LYN
Tyrosine-protein kinase Lyn

1

17

Small-scale

0.665

High

593628

BLK
Tyrosine-protein kinase Blk

1

17

Small-scale

0.618

High

778176

BTK
Tyrosine-protein kinase BTK

1

16

Small-scale

0.618

High

813526

FYN
Tyrosine-protein kinase Fyn

1

17

Small-scale

0.618

High

869550

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

1221556

MERTK
Tyrosine-protein kinase Mer

1

18

Small-scale

0.618

High

1298746

BLNK
B-cell linker protein

1

6

Small-scale

0.618

High

1298745

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

3

High-throughput

0.590

High

1021389

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.560

High

540224

FINC
Fibronectin

1

1

High-throughput

0.528

High

1036604

SOS2
Son of sevenless homolog 2

1

6

High-throughput

0.528

High

549404

ITB2
Integrin beta-2

1

2

High-throughput

0.501

High

1064931

RUNX2
Runt-related transcription factor 2

1

1

Small-scale

0.479

High

1297716

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

1282233

FACD2
Fanconi anemia group D2 protein homolog

1

0

High-throughput

0.458

High

266878

E41L2
Band 4.1-like protein 2

1

1

High-throughput

0.457

High

559579

GELS
Gelsolin

1

4

High-throughput

0.457

High

1021110

BACH2
Transcription regulator protein BACH2

1

2

High-throughput

0.457

High

1221608

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.457

High

1223827

TRI27
Zinc finger protein RFP

1

2

High-throughput

0.457

High

1223952

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.457

High

1225535

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

2

High-throughput

0.457

High

1297347

FLNA
Filamin-A

1

5

High-throughput

0.457

High

1298742

ERRFI
ERBB receptor feedback inhibitor 1

1

1

High-throughput

0.457

High

1298744

NDC80
Kinetochore protein NDC80 homolog

1

1

High-throughput

0.457

High

1298748

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.457

High

1298749

PDC6I
Programmed cell death 6-interacting protein

1

2

High-throughput

0.457

High

236667

REPS1
RalBP1-associated Eps domain-containing protein 1

1

0

High-throughput

0.438

High

663481

CRYAB
Alpha-crystallin B chain

1

0

High-throughput

0.438

High

818822

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.438

High

644392

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

2

High-throughput

0.437

High

266989

FHL2
Four and a half LIM domains protein 2

1

1

High-throughput

0.417

High

1297384

TOX4
TOX high mobility group box family member 4

1

3

High-throughput

0.417

High

1298747

PHC2
Polyhomeotic-like protein 2

1

1

High-throughput

0.417

High

204775

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.238

Low

907960

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.238

Low

913120

UCK1
Uridine-cytidine kinase 1

1

0

High-throughput

0.238

Low

1298741

SH3K1
SH3 domain-containing kinase-binding protein 1

1

0

High-throughput

0.238

Low

1298743

Q9CZL0
GOLD domain-containing protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025